巻号一覧
36 巻, 8 号
選択された号の論文の10件中1～10を表示しています
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Jun IKEDA, Toshimitsu AIDA, Yutaka SAWAMURA, Hiroshi ABE, Sadao KANEKO ...1996 年 36 巻 8 号 p. 555-559
発行日: 1996年
公開日: 2006/04/10
ジャーナル フリーThis phase II clinical study evaluated the use of 5-(3-3''-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC) pretreatment to reduce cellular resistance and enhance the antitumor effects of chloroethyl nitrosoureas in 32 patients with supratentorial malignant gliomas, including 13 anaplastic astrocytoma and 19 glioblastoma multiforme. All patients received a total dose of 50-65 Gy radiation therapy after surgery. Chemotherapy consisted of DTIC (1 mg/kg) on days 1-5, 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (2 mg/kg) on day 5, and vincristine (0.02 mg/kg) on days 1 and 15 every 5 weeks. One patient achieved complete response and 12 patients showed partial response. Median survival time was 18 months and median time-to-progression was 11 months. No significant toxicity was encountered. There was no significant benefit of this pretreatment to combination chemotherapy when compared with previous results. This study does not support a further role for DTIC as a depleter of O6-alkylguanine deoxyribonucleic acid alkyltransferase activity preceding chloroethyl nitrosourea-based chemotherapy.抄録全体を表示PDF形式でダウンロード (325K) -
Masaaki UNO, Shin UEDA, Hideki HONDO, Keizo MATSUMOTO, Masafumi HARADA1996 年 36 巻 8 号 p. 560-567
発行日: 1996年
公開日: 2006/04/10
ジャーナル フリーProton magnetic resonance spectroscopy (MRS) and single photon emission computed tomography (SPECT) were used to evaluate chronic ischemic regions in 26 stroke patients before and 1, 3, and 6 months after revascularization surgery. The volume of interest for proton MRS was placed in an area including part of the frontal and temporal opercula, insular cortex, and basal ganglia. Twenty healthy volunteers served as controls for proton MRS. Patients were divided into three groups according to the preoperative proton MRS. Group A (n = 12) had significantly lower N-acetylaspartate/choline (NAA/Cho) and N-acetylaspartate/creatine (NAA/Cr) ratios on the operative side compared to those on the contralateral side, and also lower than those in normal subjects. In seven patients in Group A, postoperative serial proton MRS demonstrated no recovery of these ratios on the operative side. However, proton MRS of the other five patients indicated gradual improvement in these ratios on the operative side at 3 to 6 months after surgery, and SPECT indicated an increase in cerebral blood flow on the operative side in four of these five patients. In Group B (n = 9), proton MRS and SPECT showed no laterality before revascularization and no remarkable change during the postoperative course. In Group C (n = 5), NAA/Cho or NAA/Cr decreased on the contralateral side preoperatively. Two patients showed fluctuating values of NAA/Cho or NAA/Cr during the postoperative period. Serial proton MRS and SPECT studies may be useful for the evaluation of revascularization surgery on ischemic regions. The efficacy of revascularization surgery on the metabolism may appear gradually within 3-6 months.抄録全体を表示PDF形式でダウンロード (521K) -
Tadashi KAWAGUCHI, Shigeki KAMEYAMA, Ryuichi TANAKA1996 年 36 巻 8 号 p. 568-574
発行日: 1996年
公開日: 2006/04/10
ジャーナル フリーEpileptogenic factors associated with cerebral convexity or parasagittal meningiomas were investigated by retrospective analysis of clinical symptoms and computed tomographic findings in 83 consecutive patients. The patients were divided into Group A consisting of 27 patients presenting with epilepsy as the first symptom, and Group B consisting of 56 patients presenting with other symptoms. Tumor location, tumor size, histological subtype, and the amount of peritumoral edema were compared between the groups. Tumor size, location, and histological subtype did not differ significantly between the two groups, but the area of peritumoral edema was significantly greater in Group A than in Group B. Similar results were found in subgroups of patients with frontal meningioma, central meningioma, and fibroblastic meningioma. Generalized seizures tended to occur in patients with frontal or fibroblastic meningioma, and partial seizures in those with central or parietal meningioma. Peritumoral edema is a significant epileptogenic factor associated with both cerebral convexity and parasagittal meningiomas, and may be especially related to the occurrence of secondarily generalized seizures in frontal and fibroblastic meningiomas.抄録全体を表示PDF形式でダウンロード (392K) -
Masahiro OGINO, Hiroshi INOUE, Shun-ichi HARADA, Hirohisa HORINOUCHI, ...1996 年 36 巻 8 号 p. 575-579
発行日: 1996年
公開日: 2006/04/10
ジャーナル フリーA 57-year-old male with a past history of bilateral pulmonary arteriovenous fistulas (PAVFs) experienced a sudden onset of headache and gait disturbance. There was a family history of PAVF and recurrent epistaxis. He had diffuse telangiectasia of the tongue, and hereditary hemorrhagic telangiectasia was diagnosed. Neuroimaging revealed a brain abscess in the right cerebellar hemisphere, which was successfully aspirated under ultrasound guidance. The PAVFs were resected afterwards in twostaged operation. No recurrence of the abscess has been observed. Cerebral abscesses complicated by PAVF are usually supratentorial. Complete eradication of PAVF is essential because the brain abscess will sometimes recur if the PAVF is left untreated.抄録全体を表示PDF形式でダウンロード (445K) -
Kensuke SUZUKI, Takao KAMEZAKI, Koji TSUBOI, Eiki KOBAYASHI1996 年 36 巻 8 号 p. 580-582
発行日: 1996年
公開日: 2006/04/10
ジャーナル フリーA 78-year-old female presented with a nontraumatic acute subdural hematoma (ASDH) caused by hemorrhage from a cavernous angioma located on the convexity dura mater. The hematoma and angioma were removed successfully. Neuroimaging performed 2 years previously had not revealed cavernous angioma. The angioma most likely grew rapidly over the 2 year period, during which she had received oral antiplatelet medication. Nontraumatic ASDH may originate from a cavernous angioma which grows rapidly.抄録全体を表示PDF形式でダウンロード (350K) -
Katsumi MATSUMOTO, Amami KATO, Keiko FUJII, Toshiyuki FUJINAKA, Ryutar ...1996 年 36 巻 8 号 p. 583-585
発行日: 1996年
公開日: 2006/04/10
ジャーナル フリーAn 84-year-old female presented with bilateral giant intracavernous carotid artery aneurysms manifesting as right total ophthalmoplegia and trigeminal nerve paresis. Computed tomography and magnetic resonance imaging showed the two aneurysms as one fused mass, so the initial diagnosis was a parasellar tumor occupying the bilateral cavernous sinuses. The correct diagnosis required cerebral angiography. Considering her age, no surgical or interventional treatment was given. Eight months later, her right eye movement partially recovered and she had no further symptoms. There was no definite causative factors other than aging in this case.抄録全体を表示PDF形式でダウンロード (265K) -
Yasuo MURAI, Daizo YOSHIDA, Yukio IKEDA, Akira TERAMOTO, Toyoyuki KOJI ...1996 年 36 巻 8 号 p. 586-589
発行日: 1996年
公開日: 2006/04/10
ジャーナル フリーA 39-year-old female presented with acute intraventricular hemorrhage manifesting as sudden onset of headache associated with gradually progressing somnolence and left oculomotor nerve paresis. Intraventricular hemorrhage occurred from a meningioma of the lateral ventricle. Computed tomography and magnetic resonance (MR) imaging revealed intraventricular hemorrhage and a mass in the right trigone. The tumor was totally removed. Her postoperative course was uneventful except for left homonymous hemianopia. The histological diagnosis was fibroblastic meningioma. The MR imaging was highly suggestive of hemorrhage from the tumor periphery.抄録全体を表示PDF形式でダウンロード (399K) -
Toshihiko KUROIWA, Shiro NAGASAWA, Terumasa KUROIWA, Tomio OHTA1996 年 36 巻 8 号 p. 590-592
発行日: 1996年
公開日: 2006/04/10
ジャーナル フリーA 49-year-old female presented with a 2-year history of occipitalgia, a 3-month history of dysesthesia, and dull sensation of the left upper extremity. T1-weighted magnetic resonance (MR) imaging revealed a low-intensity mass without gadolinium-diethylenetriaminepenta-acetic acid enhancement extending from the cisterna magna to the spinal canal. T2-weighted MR imaging revealed a high-intensity mass. Neuroradiological findings were inadequate to establish the mass as intra-axial or extra-axial. Operative findings discovered an intra-axial mass which was totally removed. Histological examination found the mass was an oligoastrocytoma. Cerebellar glioma developing exophytically is very rare. Adequate surgical removal is possible and likely to be curative if total.抄録全体を表示PDF形式でダウンロード (386K) -
Yutaka HONMA, Kenya KAWAKITA, Seigo NAGAO1996 年 36 巻 8 号 p. 593-597
発行日: 1996年
公開日: 2006/04/10
ジャーナル フリーA 60-year-old male presented with a rare intramedullary spinal cord metastasis from thyroid carcinoma manifesting as rapidly worsening motor and sphincter disturbances. The primary tumor had been treated 11 years previously. Magnetic resonance imaging clearly revealed the hemorrhagic tumor localized in the thoracic spinal cord and an associated, asymptomatic metastasis in the cerebellum. The hypervascular tumors were totally removed. The histological diagnosis was papillary adenocarcinoma. He has been stable for 2 years postoperatively. Surgical resection of intramedullary metastasis should be considered in patients with less malignant tumors such as thyroid carcinoma, especially when accompanied by progressive compression myelopathy.抄録全体を表示PDF形式でダウンロード (438K) -
Ikuhide KOHAMA, Tsutomu SOHMA, Katsuyuki NUNOMURA, Koji IGARASHI, Akas ...1996 年 36 巻 8 号 p. 598-601
発行日: 1996年
公開日: 2006/04/10
ジャーナル フリーA 1-year and 10-month-old girl presented with an intraparenchymal meningioma in the left frontal lobe manifesting as grand-mal seizures. Computed tomography and magnetic resonance images revealed a round, well-demarcated mass in the left frontal lobe which was homogeneously enhanced. Angiography showed the feeding arteries of the tumor from the middle cerebral artery. The preoperative diagnosis was an intraaxial tumor. At operation, the lesion was totally embedded in the frontal lobe without any connection to the overlying dura or the ventricular system. Some small feeders from the middle cerebral artery were coagulated and the tumor was totally removed. The histological diagnosis was fibroblastic meningioma. Her postoperative course was uneventful. She was doing well 2 years after surgery. Intraparenchymal meningiomas may be seen more frequently than expected in children. Absence of dural attachment is characteristic of pediatric meningiomas.抄録全体を表示PDF形式でダウンロード (389K)
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