A series of
S-furfuryl thiocarboxlates were synthesized and their physiological activity was examined. The thioesters examined in this study (
1D-
16D) were prepared either from the corresponding aldehydes (
6A-
8A,
14A, and
15A), nitriles (
4B and
5B), or from carboxylic acids (
1C-
3C,
9C-
13C, and
16C) by condensing carboxylic acid intermediates (
1C-
16C) with furfuryl mercaptan which is known as a component of coffee fragrance. Carboxylic acid derivatives were condensed with furfuryl mercaptan from
Rubiaceae Coffee arabica to obtain thioester
1D-
16D in 52-92% yield. The physiologcal activity of products
1D-
16D toward
Tyrophagus putrescentiae (T. p.), Dermatophagoides farinae (D. f.), Ornithonyssus bacoti (O. b.), and
Culex pipiens pallens (C. p. p.) were measured. Products
1D-
6D,
8D, and
12D had higher miticidal activity than
N,
N-diethyl-
m-toluamide (DEET) for
T. p. and
D. f.
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