Studies were made of th e effects of estrogenic hormone administration on the anterior pituitary and the testis of the adult male mouse.
A c idophiles gradually decreased in number with the progress of injections and these acidophiles were well granulated in general. In the medium dosage administration group, at the early stage slight increase in number of acidophiles was temporarily observed, when there were somewhat frequently found acidophiles with the negative image of Golgi apparatus, with perinuclear halo and with basophilic filamentous substance in the cytoplasm. At that time, large acidophiles were sometimes observed.
Delta-cells showed conspicuous degranulation in general. In the medium dosage administration group, a great number of delta-cells reacted weakly with PAS reagent and indicated a chromophobic appearance. No signs of degeneration in this cell type were encountered throughout this experiment.
Theta-cells showed abu n dant occurrence in proportion to the increase in administration dosages. But in the high dosage administration group, theta-cells were observed less frequently than in the medium dosage group.
With the progress of this experiment the decrease in size and weight of the testis became marked. This depended on-atrophy of the tubuli seminiferi, ontorci but not on that of the interstitial tissue. In the tubuli seminiferi contorci the normal development of spermatogenesis was markedly inhibited.
抄録全体を表示