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Volume 52 (1975 - 197･･･
- Issue 6 Pages 285-
- Issue 5 Pages 233-
- Issue 4 Pages 151-
- Issue 2-3 Pages 59-
- Issue 1 Pages 1-
Predecessor
Volume 52, Issue 2-3
Displaying 1-5 of 5 articles from this issue
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Teizo Ogawa1975 Volume 52 Issue 2-3 Pages 59-71
Published: August 20, 1975
Released on J-STAGE: September 24, 2012
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Takao Setoguti, Yukinori Satou1975 Volume 52 Issue 2-3 Pages 73-83
Published: August 20, 1975
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSFilamentous bundles associated with centrioles were occasionally observed in the capillary endothelial cells of the ciliary muscle of two crab-eating monkeys. They arise from one or both of a pair of centrioles and usually take a straight course either nearly parallel or rather perpendicular to the luminal surface of the endothelial cell. Sometimes, two bundles of filaments which originate from two different centrioles are fused into one thicker bundle.
These bundles of filaments show a clear striation which consists of alternate dark narrow and light wide bands with a periodicity of 600 to 900Å. Furthermore, each light band indicates 7 or 9 alternate dark and light parallel subbands.View full abstractDownload PDF (5369K) -
Hiroshi Hanai, Takashi Hanai, Haruyoshi Otsuka, Akira Yamanaka1975 Volume 52 Issue 2-3 Pages 85-101
Published: August 20, 1975
Released on J-STAGE: September 24, 2012
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Fumio Ariyuki1975 Volume 52 Issue 2-3 Pages 103-117
Published: August 20, 1975
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSPregnant ICR-JCL mice, Wistar rats, and Japanese white rabbits were injected intraperitoneally with doses of 0.2 to 80 mg/kg of diltiazem hydrochloride, a coronary vasodilator, on successive days in the period of organogenesis. Further, the drug was given via the same route in a single dose of 3.1 to 80 mg/kg on various days of gestation to pregnant mice and rats from the same colonies used in the above experiments. The animals were sacrificed at term and their fetuses were examined for gross external and skeletal anomalies in cleared specimens stained with alizarin red S. The main results were:
1. Pregnant mothers tolerated well all doses.
2. The fetal mortality rate after the successive injections was significantly high at the dose levels of 12.5 mg/kg and over in mice and rabbits, and at 80 mg/kg in rats as compared with the controls.
3. The successive injections induced an appreciable number of externally malformed fetuses in rats and rabbits at 80 mg/kg and at 12.5 mg/kg, respectively, but not in mice. Malformations of the limbs and tail were the main types of defects observed.
4. A small number of fetuses with vertebral and rib deformities were observed in all of the three species after the successive injections.
5. The single injection experiments revealed that the susceptibility to the embryolethal action suddenly increased from day 9 in mice and day 12 in rats, reached the highest level on days 10 and 11 in mice and on day 12 in rats, and gradually decreased thereafter. On the most susceptible days, the fetal LD50 was estimated to be between 6.3 and 12.5 mg/kg in mice and between 40 and 80 mg/kg in rats.
6. The highest incidence of gross external anomalies induced by the single injection was recorded on day 13 in mice and rats. The lowest teratogenic dose was 25 mg/kg in mice and 80 mg/kg in rats. Limb and tail anomalies predominated.
7. The injection of 25 or 50 mg/kg on day 9 in mice and of 80 mg/kg on day 11 in rats produced vertebral and rib defects.
The relationship between embryolethality and teratogenicity, and possible mechanism of the embryotoxicity are discussed.View full abstractDownload PDF (1928K) -
Christian Leithner, Helmut Sinzinger, Johann Hohenecker, Lothar Wicke, ...1975 Volume 52 Issue 2-3 Pages 119-149
Published: August 20, 1975
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSWe investigated the angiograms of 61 grown-up,33 males and 28 females, aged between 17 and 74 years. In its course the aorta was gradually approaching the median line, the calibre decreased from Th12(26 mm) down to the aortic bifurcation (19 mm). The aortic bifurcation had a mean angle of 37°C, the iliac bifurcation one of 29°on the right and 20°on the left side. In the mean the aortic bifurcation had a level of L.. The mean calibre of the left and right renal artery measured about 7.8 mm and differed significantly from the calibre of the splenic artery. In the mean the level of the origin of the renal arteries was slightly higher on the right than on the left side. The side-differences of the calibres of the common external and internal iliac arteries were not significant. In the higher age groups we observed a lowering of the aortic bifurcation and the origin of the renal arteries. The increase in length was particularly marked in the splenic artery. The length of the common iliac arteries varied con- siderably. This artery was rather more tortuous on the left than on the right side. This tortuosity was nearly always found in patients suffering from hypertension.View full abstractDownload PDF (6157K)
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