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Volume 31, Issue 6
Displaying 1-13 of 13 articles from this issue
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Tatsuya Fujii, Tomoko Miyajima, Masatoshi Ito, Takehiko Okuno, Izuru M ...1999 Volume 31 Issue 6 Pages 505-510
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo diagnose spinal muscular atrophy (SMA), we examined the deletion of exons 7 and 8 of the survival motor neuron (SMN) gene and exon 5 of the neuronal apoptosis inhibitory protein (NAIP) gene in 7 patients from 6 unrelated families, using the polymerase chain reaction method. Two patients with type I and two with type II SMA had the deletion in SMN, whereas 2 of the 3 patients with type ifi had no deletion in these genes. Thus, the method was not as useful in type III as in type I and H for making a diagnosis of SMA. Together with the data previously reported by others, our data indicated the possibility that the deletion frequency in type ifi SMA is lower in Japanese patients (<40%) than in non-Japanese patients (>80%). Two siblings had SMA of different severity; the older brother having type ifi and the younger brother type II. Both had the same deletion in the SMN gene. The different phenotypes in these siblings with the same genotype indicated that caution is required when utilizing molecular data for genetic counseling or prenatal diagnosis of SMA.View full abstractDownload PDF (1116K) -
Evaluation of Serial Event-Related Potentials (N130, N180, P250)Chikako Ono, Masao Aihara, Kazuo Hatakeyama, Yuhko Kamiya, Hideaki Kan ...1999 Volume 31 Issue 6 Pages 511-518
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSerial event-related potentials (ERPs), especially the negative components before P300, were recorded to evaluate the developmental changes of awareness, or intentional attention. In this study, 36 healthy children (5-16 years of age) and eight healthy adults (19-37 years) were told to perform two attentive para.-digms: passive and active. Each test condition consisted of 16 electrical stimuli. Four trials were averaged in sequence and then evaluated as serial four blocks.
With repetition in both passive and active attentive paradigms the amplitude of N130 was not attenuated until six years old. During active attention, N180 remained undiminished in adolescents and adults. The amplitude of P250 decreased with repetition during passive attention in children over seven years old, but was not attenuated during active attention in adults.
These results suggest that N130 reflects the orienting reflex, and that N180 is associated with the process to maintain awareness.View full abstractDownload PDF (3050K) -
Hideaki Kanemura, Masao Aihara, Shigeki Aoki, Kazuo Hatakeyama, Yuhko ...1999 Volume 31 Issue 6 Pages 519-524
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis article describes the measurement of the frontal and prefrontal lobe volumes on three dimensional (3-D) MRI in 13 children aged 5 months to 14 years and in 3 adults aged 27 to 39 years. The 3-D MRI data were acquired by the fast spoiled gradient recalled (SPGR) sequence using a 1.5 T MR imager. The frontal and prefrontal lobe volumes were measured by the volume measurement function of the Workstation. We confirmed that this technique to analyze segmental brain volumes archieved acceptable levels of reliability and accuracy. There was an increase in the frontal and prefrontal lobe volumes with advancing age, being rapid between 8 and 15 years of age. The prefrontal to frontal lobe volume ratio also increased gradually, with spurts between 8 and 15 years of age. This approach may be particularly useful for studies on patients with frontal and prefrontal lobe dysfunctions.View full abstractDownload PDF (2669K) -
Ventral Cochlear Nucleus and Superior Medial Olivary NucleusTakahiro Nara, Noboru Goto, Shinichiro Hamano1999 Volume 31 Issue 6 Pages 525-530
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe development of the human ventral cochlear and medial superior olivary nuclei was studied. We made serial sections of the brain in 10 fetuses at 16-40 weeks of gestation (WG), an infant at 2 months of age and an adult of 63 years using an electronic planimeter with a computer. Although the shape of neurons of the two nuclei was different, our morphometric analysis showed that the development of both of them accelerates between 18 and 21 WG in terms of the columnar length and volume, neuronal size and circularity ratio and the amount of Nissl bodies increases gradually.View full abstractDownload PDF (3931K) -
Toru Kato, Fumio Hayakawa, Akihisa Okumura, Kuniyoshi Kuno, Kazuyoshi ...1999 Volume 31 Issue 6 Pages 531-534
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe reported a 10-year-old boy with congenital plasminogen abnormality resulting in recurrent cerebrovascular ischemic attacks. He suddenly developed dystonia of the left upper limb at 9 years of age. MRI demonstrated small infarcts in the right thalamus and caudate nucleus. He then had a transient ischemic attack at 10 years. He complained of headache, vertigo, diplopia, and unsteady gait. DNA analysis revealed that he was heterozygotic for abnormal plasminogen. Thus, congenital plasminogen abnormality was suspected to be a cause of recurrent cerebrovascular ischemic attacks in this case.View full abstractDownload PDF (4295K) -
Mari Hayasi, Yuko Arizono1999 Volume 31 Issue 6 Pages 535-541
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe present two case reports with severe hypoxic encephalopathy at birth. Studies carried out in the NICU included cranial ultrasonography, CT, and MRI. Due to abnormalities found by the latter two they were referred to our center at the age of two months and one month, and then an early Vojta therapy commenced. Changes were monitored periodically by assessing their spontaneous movements, postural reactions and neurological manifestations. The first case presented with ventricular hemorrhage and was diagnosed as having severe CCD (central coordination disturbance) with the risk of athetotic type cerebral palsy. The second case presented with severe low density in the frontal and temporo-parietal white matter and was diagnosed as having moderate CCD with the risk of mental retardation or brain atrophy. Although their status fluctuated temporarily, the two infants didn't show any paresis or mental retardation. Recently the studies on mechanisms of brain plasticity have advanced. The findings of our experience might suggest that the plasticity of an immature brain could be enhanced by the very early Vojta therapy. We propose that a therapeutic intervention should commence early before clinical symptoms become evident.View full abstractDownload PDF (7465K) -
Miki Inutsuka, Masaomi Wada, Kazuya Goto, Atsuhiko Haigo, Tatsuro Izum ...1999 Volume 31 Issue 6 Pages 543-548
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe reported a 10-year-old boy with an interhemispheric subdural empyema caused by acute excerbation of frontal sinusitis. He has suffered from allergic rhinitis and pansinusitis for years. He had fever and a generalized tonic-conic seizure, followed by prolonged consciousness disturbance and right hemiparesis. CT and MRI were useful to diagnose an interhemispheric subdural empyema, which showed a characteristic double- layer fluid collection pattern. Prompt diagnosis and treatment with craniotomy resulted in recovery without any neurological sequelae. His basic disorders, allergic rhinitis and pansinusitis, were successfully treated with macrolides and antiallergic drugs: pranlukast hydrate and sodium cromoglicate, administered per os and by inhalation, respectively.View full abstractDownload PDF (5808K) -
Kiyotaka Murakami1999 Volume 31 Issue 6 Pages 549-552
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSI report here a case of late onset Group B Streptococcus (GBS) meningitis with transient oculomotor nerve palsy. The boy was admitted to our hospital at 25 days of age. On the 5th hospital day, he was found to be unable to open the left eye. Although light reflex of both the eyes was intact, the left eye was deviated to the left lateral side. We administered intravenously steroid hormone and antibiotics. His eye movements were normalized on the 30th hospital day.
Oculomotor nerve palsy in this case may have been caused by vasculitis of the middle cerebral artery. This case shows that steroid hormone is effective for vascular edema complicating neonatal meningitis.View full abstractDownload PDF (2791K) -
Masao Adachi, Yoshiko Ai, Eisaku Maeda1999 Volume 31 Issue 6 Pages 553-557
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA full-term baby was born to an epileptic mother treated with two anti-epileptic drugs, sodium valproate and phenobarbital, throughout the pregnancy. She was given no information about the risk of teratogenesis of these drugs. At birth the patient was hypotonic and had clinical features specific for the fetal valproate syndrome. After a viral infection at three months of age, he had intractable and persistent wheezing. Suspecting the presenceo f congenital respiratory tract abnormality, w e performedt racheobronchoscopyw, hich revealed a relatively big submucosal tumor on the left trachial wall below the vocal cord. Dyspnea and wheezing were remarkably improved by tracheolaryngotomy, but he died suddenly and unexplainedly at seven months of age.View full abstractDownload PDF (4202K) -
Yasushi Itoh, Shigeru Nagaki, Noboru Kuyama, Koichi Hirano, Mariko Sun ...1999 Volume 31 Issue 6 Pages 559-564
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report a 6-month-old female infant with status convulsivus which appeared during intravenous drip infusion of aminophylline. She had an extremely high serum theophylline concentration (79μg/ml), which was effectively reduced by plasmapheresis and dialysis.
Three days later, she developed status convulsivus again, though her serum theophylline was undetectable at that time. A CT on 14th day of illness revealed mild widening of frontal sulci and Sylvian fissure. The patient apparently recovered her healthy condition, but psychomotor developmental delay, especially in speech and social behavior, was noted at the age of 2 years 6 months (DQ=55). A delay of myelination was observed on brain MRI at 4 year 1 months, suggesting an irreversible brain injury caused by theophylline intoxication.View full abstractDownload PDF (2390K) -
Noriyuki Akasaka, Hiroshi Hayakawa, Takayoshi Okugawa, Takayuki Kasaha ...1999 Volume 31 Issue 6 Pages 565-570
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report serial cerebral computed tomography (CT) and magnetic resonance imaging (MRI) in a case of hemolytic uremic syndrome (HUS) with the complication of the central nervous system due to Escherichia coli O157:H7. Although initial brain CT was normal, follow-up CT and MRI revealed lesions in the white matter and bilateral basal ganglia, representing brain edema and infarcts, respectively. Especially, lesions in the bilateral basal ganglia were very unique. Serial CT and MRI findings are useful to understand the mechanismo f the complicationso f the central nervous systema ssociatedw ith HUSView full abstractDownload PDF (8322K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1999 Volume 31 Issue 6 Pages 571-573
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESS -
[in Japanese]1999 Volume 31 Issue 6 Pages 579-581
Published: November 01, 1999
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (526K)
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