脳と発達
Online ISSN : 1884-7668
Print ISSN : 0029-0831
ISSN-L : 0029-0831
4 巻, 3 号
選択された号の論文の12件中1~12を表示しています
  • 田中 晴美, 有馬 正高, 飯野 晃啓
    1972 年 4 巻 3 号 p. 179-181
    発行日: 1972/05/01
    公開日: 2011/05/24
    ジャーナル フリー
  • 小川 次郎
    1972 年 4 巻 3 号 p. 182-185
    発行日: 1972/05/01
    公開日: 2011/05/24
    ジャーナル フリー
  • 自験例を中心に
    西田 和男, 佐藤 進, 本間 一成
    1972 年 4 巻 3 号 p. 186-190
    発行日: 1972/05/01
    公開日: 2011/05/24
    ジャーナル フリー
    A case of congenital dermal sinus associated with dermoid cyst was reported. A dermoid cyst, which overlay the vermis, was found in the posterior fossa of a 2 year-old male infant, who developed an acutely increased intracranial pressue (IICP) and cerebellar signs. This dermoid cyst connected with a congenital dermal sinus which was diagnosed externally by an abnormality of hair growth and a subcutaneous tumor (dermoid cyst) over the mid portion of the ccciput.
    The relation of this congenital dermal sinus to central nervous disturbance is discussed. Many cases of infection of the central nevous system (meningitis, abscess) are reported most frequently. Congenital tumors (epidermoid, dermoid) are also there, which may obstruct spinal fluid circulation and cause IICP and hydrocephalus.
    The etiology of congenital dermal sinus and its incidence, symptom, diagnosis, and treatment are discussed.
    A careful search for congenital dermal sinus should be made in any children having repeated intracranial infection or IICP.
    The importance of early recognition of the sinus and complete extirpation of the sinus before neurological complication developed is emphasized.
  • アミノ酸代謝異常症に於ける知能障害の成因に対するアプローチ (続報)
    高田 五郎, 多田 啓也
    1972 年 4 巻 3 号 p. 191-196
    発行日: 1972/05/01
    公開日: 2011/05/24
    ジャーナル フリー
    Hyperaminoacidemia was induced in 17-day-old rats by intraperitoneal injection of a single amino acid and the free amino acid pattern in the brain was analysed at 1 hour after the injection.
    A significant alteration of the free amino acid pattern in the brain was observed by the loading of phenylalanine, histidine, valine or methionine, respectively.
    These findings suggest that the inhibition of amino acid transport by excess of a single amino acid may result in decrease of essential amino acids and in reduced rate of brain protein synthesis.
  • 横田 清, 名和 顕子, 竹下 研三, 朝長 正道
    1972 年 4 巻 3 号 p. 197-204
    発行日: 1972/05/01
    公開日: 2011/05/24
    ジャーナル フリー
    Presenting three cases of children, the authors discussed the atlanto-axial dislocation from etiolog ical, symptomatological, roentgenographical and therapeutic viewpoints.
    Case 1, a 15-year-old boy, showed a slight limping already at the age of 2. The limping slowly progressed later on, and had developed into nearly a complete right hemiplegia by the age of 13. A left hemihypesthesia became evident as the motor weakness progressed. X-ray studies demonstrated a basilar impression and other malformations around the foramen magnum as well as an abnormal anterior dislocation of the atlas upon anterior flexion of the neck. A suboccipital craniectomy including upper cervical laminectomy and dural plasty was performed for decompression of the neural elements.
    Case 2, a girl aged 2 years and 11 months, was admitted with complaints of progressive gait distur bance and neck pain of three months' duration. On admission, the bilateral lower and left upper extremities were markedly weak. There was positive Babinski sign on the left. Roentgenogram showed a considerable atlanto-axial dislocation associated with a hypoplasia of the odontoid process. Fixation and fusion of the occipital bone, atlas and axis were attempted with a bone graft and wire.
    Case 3, a boy of 15 years, was a single child of parents with consanguinity of cousins, and had a history of multiple pathological fractures of the extremities. X-ray films of the long bones suggested osteopoikilosis. Just before admission, he had a sudden and transient quadriplegia and dysesthesia throughout the body, when his head was pushed forward. Cervical films showed a separation of the apical portion of the odontoid process and a marked anterior dislocation of the atlas on neck flexion. A high collar was applied and he has been doing well until the present.
  • 3剖検例の中枢神経病変について
    満留 昭久, 高嶋 幸男, 竹下 研三
    1972 年 4 巻 3 号 p. 205-211
    発行日: 1972/05/01
    公開日: 2011/05/24
    ジャーナル フリー
    Three autopsy cases of infantile spinal muscular atrophy were reported. Neuropathological examina tion of the central nervous system of 3 cases revealed degeneration of the nerve cells in the spinal and cranial nerve motor nuclei, which showed loss of nerve cell, central chromatolysis, pyknosis and ballooned cell.
    There was nerve cell degeneration in the 5 th layer of the precentral gyrus in all cases.
    Moreover, in one case there were loss of the ependymal cells, poor myelination and gliosis of the cerebral deep white matter and loss of the Purkinje cells.
    These changes in cerebrum and cerebellum were ascribed to anoxia resulting from the terminal respiratory distress.
  • 渡辺 一功, 岩瀬 勝彦, 原 紀美子
    1972 年 4 巻 3 号 p. 212-221
    発行日: 1972/05/01
    公開日: 2011/05/24
    ジャーナル フリー
    Three-hour polygraphic recordings were performed in early premature infants born between 24 and 31 weeks of gestational ages.
    Although two sleep states can be identified behaviorally as early as 24 weeks of post-conceptional age, there is no electroencephalographic difference between active and quiet sleep at 24-25 weeks. There is no regular cyclic organization of sleep as seen at later post-conceptional ages. In either sleep EEG shows a burst-flat pattern. Active sleep is an ill-defined sleep state, rarely fulfilling all the be havioral and polygraphic criteria of REM sleep. Quiet sleep is more distinct sleep state, though sub mental EMG israrely present.
    After 26 weeks, EEG becomes more continuous in active sleep, though often interrupted by briefer isoelectric episodes than in quiet sleep.
    After 32 weeks, EEG shows high amplitude continuous tracing in active sleep.
    In contrast, EEG in quiet sleep shows no remarkable changes, consisting of the burst-flat activity from 24 through 31 weeks.
    The amount of quiet sleep ranged 30-40% of the total sleep time in this age period. Later diminition of active sleep can be ascribed to later deliniation and separation of REM sleep from an illdefined active sleep which might comprise precursor of REM, drowsiness and even light sleep.
    The modal value of burst-burst intervals of the burst-flat pattern in quiet sleep were found to be relatively constant from 24 through 40 weeks, though longer intervals are more frequent in the younger prematures.
    Well-defined visusal and auditory evoked responses were observed even in the flat part of the burst-flat activity as early as 25 weeks of post-conceptional age.
  • 高嶋 幸男, 田中 健蔵
    1972 年 4 巻 3 号 p. 222-227
    発行日: 1972/05/01
    公開日: 2011/05/24
    ジャーナル フリー
    The studies were made on the vascular architecture in the subependymal matrix of the autopsied neonatal cases with the injection of barium sulfate suspension into the cerebral vascular system through the aortic arch or the superior vena cava.
    The fixed brain was cut with the thickness of 0.5, 1.0 or 2.0 cm. These sections were photographed by a soft X-ray apparatus. Then the thinner sections of 200 to 500 it were stained with benzidine.
    The distal portions of the long medullary arteries turned at the borderline between the subependymal matrix and the cerebral white matter, and runned parallel along the ventricular wall, branching the small arteries to the subependymal matrix.
    The capillaries in the subependymal matrix were greater than those in the cerebral cortex or white matter.
    The axis of capillary net works were arranged parallel to ventricular walls in the subependymal matrix, and vertically to venricular walls in the deep cerebral white matter.
    The subependymal veins were localized at the subependymal matrix near the borderline between the cerebral white matter and the subependymal matrix. The subependymal veins branched into the subependymal matrix as small veins.
    Fibrinolytic activity of brain tissue in the subependymal matrix, cerebral cortex and white matter was studied by Astrup's biochemical method.
    Fibrinolytic activity (tissue activator) was higher in the subependymal matrix than in cerebral cortex and white matter.
  • 岡 エイ次, 伴 鶴一, 山磨 康子, 井上 英雄, 大田原 俊輔
    1972 年 4 巻 3 号 p. 228-238
    発行日: 1972/05/01
    公開日: 2011/05/24
    ジャーナル フリー
    For the purpose of elucidating the pathophysiology of severely handicapped children and of offering some clues to the adequate medical measures, we studied EEGs of 127 severely handicapped children, and obtained the results as follows.
    1) Every case in this study showed EEG abnormalities. Diffuse low voltage dysrhythmia (40.1%) and diffuse slow wave dysrhythmia (37.8%) were the most frequent abnormalities in the basic pattern. However, the asymmetry of the focal abnormality was seen in only 5.5% of all cases.
    2) The epileptic discharge was noted in 94.4% of the cases with clinical epilepsy and in 61.6% of those without clinical epilepsy. The epileptic focus was localized most often in the occipital region (24.0%), whereas only 5.2% of epileptic cases presented the focus in the temporal region which is seen more often in epileptic children in general. It was also shown that the many cases reveal diffuse cortical projection from the subcortical foci.
    3) As for the types of clinical seizures, grand mal was the most frequent (44.4%), and next the Lennox syndrome (20.4%).
    4) These characteristic findings in EEG indicate that not only the extensive lesion of the cerebral cortex but also the lesions of the subcortical structures, especially the diencephalon and of the brainstem, play a significant role in the pathophysiological mechanism of severe psychoneurological disturbances.
  • 児玉 荘一, 根岸 宏邦, 天川 博子
    1972 年 4 巻 3 号 p. 239-249
    発行日: 1972/05/01
    公開日: 2011/05/24
    ジャーナル フリー
    Three cases of spike-wave stupor are reported and the literature to date is reviewed.
    We interprete the spike-wave stupor, in a wide sense, as the stupor of long duration with generalized spike-wave rhythms on EEG. Therefore it includes not only the petit mal status but also the stupor state in other types of epilepsy.
    While the classical anticanvulsants are not so effective against the spike-wave stupor, ACTH and steroids have a fairly good effect on the clinical signs as well as on EEG.
    We coiclude that ACTH or steroids must be tried in the treatment for spike-wave stupor.
  • 特にRadioisotope診断の意義について
    高梨 邦彦, 伊東 洋, 三輪 哲郎
    1972 年 4 巻 3 号 p. 250-256
    発行日: 1972/05/01
    公開日: 2011/05/24
    ジャーナル フリー
    On the pathological state of the subdural accumulation of cerebrospinal fluid-like material, Mayo, in 1894, offered the name of brain cyst, followed by such designations as subdural hygroma, hydroma, effusion and fluid collection. Since 5 cases of traumatic subdural hydroma were reported in Japan in 1956, many reports were presented.
    Especially in infant and children, this is known to be accompanied by focal or diffuse skull bulging. The authors have recently experienced one case of subdural hydroma accompanied by left temporal lobe agenesis, with chronic distension of the skull since the time of birth without history of trauma or other disease. In addition to routine neurosurgical diagnosis, radioisotope scintigraphy by PHO/GAMMA scintillation camera was used to obtain adequate diagnosis. For such a case, the pathogenesis and various nomenclature were also discussed. It was considered that this case belongs to hydroencepha lodysplasia
  • 依田 忠雄
    1972 年 4 巻 3 号 p. 259-261
    発行日: 1972/05/01
    公開日: 2011/05/24
    ジャーナル フリー
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