In order to investigate the safety and efficacy of low energy laser irradiation to the arthritis of the patients with rheumatoid arthrtis, a multi-center double blind comparative study was conducted. Sixty eight patients with rheumatoid arthritis were randomly allocated into two groups of laser and sham irradiation. The each inflamed knee joint received 3 minut's irradiation of Ga-AI-As laser at 20mw with wave length of 830nm or 3 minut's sham irradiation, twice a week during 5 weeks. Evaluation items included pain and swelling of the knee joint, 15m walking time, ESR and morning stiffness. Routine laboratory tests including CBC, blood chemistry such as GOT, GPT, and LDH were also examined at the entry of the study and the completion of 10 times irradiation. Among various evaluation items, 15m walking time showed significant decrease in the laser group comparing with that in the sham group (P<0.01). The remaining items showed no significant differences between two groups. Laboratory data showed no remarkable changes during the study and no apparent adverse effect with irradiation was observed. These results show some beneficial effect of low energy laser therapy to the patient with rheumatoid arthritis and also safety of irradiation.
Effect of long-term intake of spa water on gastric mucosal blood flow was evaluated using an endoscopic organ reflex spectrophotometry together with an Olympus XQ-10 forward-viewing gastrofiberscope. Three healthy volunteers and nine patients with gastric diseases in remission (six with healed gastric ulcer and three with chronic gastritis) underwent two-week treatment consisting of daily intake of Misasa spa water (weakly radon containing bicarbonate salt spring, 38 to 42°C, 200ml, two times a day between meals), and gastric mucosal blood flow was measured at three spots of the stomach (lesser curvature of the pylorus, antrm, and angle) before and after the treatment period. Life style and medication were kept unchanged during the period. The following results were obtained: 1) Gastric mucosal blood flows (IHb) measured before and after the treatment were respectively 95.0±18.0 and 98.2±15.4 at the pylorus, 104.8±16.9 and 110.8±12.8 at the antrum, 116.1±20.4 and 118.7±18.5 at the angle. 2) Values measured after the treatment were higher than those measured before the treatment at pylorus in 75% of the patients and at the antrum and angle in 67% of the pa-tients. 3) However, assessment of the mean values before and after the treatment using the student's paired t-test revealed a significant increase in blood flow (P<0.05) only at the antrum. Further studies are in progress to determine (1) the clinical significance of the improvement in gastric mucosal blood flow, such as the maintenance of remission, and (2) the characteristics of gastric diseases which are likely to respond favorably to the treament of taking spa water.
A double-blind controlled test was performed to determine the analgesic effect of semiconductor laser irradiation (30mW, Ga-Al-As semiconductor laser) on various types of low back pain. In the laser irradiated group, the improvement rate (including extremely effective and effective cases) of spontaneous pain was 61%, tenderness 61.8%, and locomotion pain 64% with an overall improvement rate of 73.5%. Significant differences from the control group were thus found in all types of pain (P<0.01). No significant difference was found in the Lasegue sign and Deep Tendon Reflex (DTR) between the laser irradiated group and the control group and no organic change was found in the laser irradiated tissues. Also, no significant difference was found between the laser irradiated group and control group blood test items with no side effect or degenerative changes. This confirmed that the laser irradiation was harmless to human tissues. The effectiveness and safety of the semiconductor low energy laser have been established. The authors therefore believe that the laser irradiation will be quite useful in treating low back pain in the future.
This Study was performed to evaluate the effect of acupuncture stimulations on meridian points on gastric function. Gastric juice of healthy volunteers was examined, and the effect of acupuncture stimulations at the trunk and remote positions on the gastric acid output was observed. The followiag results were obtained: 1) Gastric juice secretion and acid output were suppressed in basal secretion but facilitated in maximal secretion. 2) The variation of gastric function was closely related to the location of stimulation; the effect of stimulation was more conspicuous at remote positions than trunk positions. 3) The variations of effect depending on the number of stimulations were conspicuous in remote positions, where a larger effect was obtained, and there was a significant difference in effect between single and consecutive stimulations.
A point process model is suitable for analysis of a sequence of binary variables, each of which may be dependent on the preceeding one. This model was used for analysis of the correlation between the state of the atmosphere and the presence or absence of asthmatic symptom known from diaries in which a day was divided into four parts. The diaries were kept during summer and autumn of a year by 19 adult and 12 child patients in Sapporo (43°03′N, 141°20′E), 39 adult and 20 child patients in Tokyo (35°41′N, 139°46′E), and 26 adult and 18 child patients in Naha (26°14′N, 127°41′E). Low temperature and decrease in temperature significantly related to the asthmatic symptom during the seasons. No reversions on correlations as to temperature were observed among places, between the adult and the child, and before and after taking in effects of the preceding symptom and/or the circadian rhythm. Some correlations relating to humidity or to barometric pressure, on the other hand, reversed from place to place, from the adult to the child, and from “before” to “after” taking in the effects. Availability of this model for further study on the correlation between the air with contents and the asthmatic symptom is shortly discussed.