II型 (細気管支閉塞型) 喘息13例を対象に, 気管支肺胞洗浄 (BAL) 液中の好中球の頻度との関連のもとに, 温泉療法の効果について検討を加えた。対象13例のうち, 7例ではBAL液中好中球増多 (BALn+) が, また残りの6例ではBAL液中好中球の増加は見られなかった (BALn-)。
1. 平均年齢は, BALn+症例で, BALn-症例に比べ低い傾向がみられた。
2. FEV1.0%は, BALn+症例でBALn-症例に比べ有意に低い値を示した (P<0.01)。また, BAL液中リンパ球頻度は, BALn+症例で, BALn-症例に比べ有意に低い値を示した (P<0.01)。血清IgG値は, 両群とも低い値を示したが, 両者間に有意の差は見られなかった。
3. BALn-症例に対する温泉療法の臨床効果は, 1ヵ月後も3ヵ月後もほぼ同様の成績であったが, BALn+症例では, 1ヵ月後の効果 (42.9%) に比べ, 3ヵ月後の効果 (71.4%) がより高い傾向が見られた。
以上の結果より, BAL液中好中球頻度が高い症例 (BALn+) に対しては, より長期的な温泉療法が必要なことが示唆された。

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努力肺活量 (FVC) が80%以下の喘息患者23例を対象に, 温泉療法の効果を検討した。
1. FVCは, Ia-1型, Ia-2型およびIb型の喘息患者で, 温泉療法により有意の改善傾向が見られたが, II型喘息では有意の改善は見られなかった。
2. 温泉療法によるFVCの有意の増加は, 50-69歳の年齢層で観察されたが, それ以下の年齢層 (49歳以下) およびそれ以上の年齢層 (70歳以上) では有意の増加は見られなかった。
3. 温泉療法によるFVCの有意の増加は, 気管支肺胞洗浄 (BAL) 液中のリンパ球および好中球の頻度の高い症例では低く, 一方, BAL液中の好酸球の頻度が高い症例では, その増加率も高い傾向が見られた。
4. これらの症例における温泉療法後の1秒量 (FEV 1.0) の改善は, 全般的に低く, 60-69歳の年齢層においてのみ有意の改善が観察された。
以上の結果より, 温泉療法は, 主として, 吉液性因子の関与する即時型喘息反応 (FEV 1.0の低下) よりも, 細胞因子がより強く関与する遅発型喘息反応 (FVCの低下) に対してより有効である可能性が示唆された。

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目的: 慢性関節リウマチ (RA) 患者と健常対照における水中超音波療法の皮膚微小循環と皮膚温への効果について検討した。
対象: 2群のRA患者と健常対照を比較検討した。RAの1群 (n=26) は低RA活動性群 (ESR21mm/hr, RF陽性67%) で他の1群 (N=28) は臨床的に亜急性手関節炎を呈する高RA活動性群 (ESR39mm/hr, RF陽性93%) であった。
方法: 皮膚微小循環は低温水 (34℃) 中で10分間超音波探触子 (1MHz, 探触子5cm², 出力1.5W/cm²) を右手関節部にあてレーザードップラー血流計により測定した。測定前後で赤外線温度計にて局所皮膚温を測定した。対照群は全く同様の手技だが, 超音波装置のスイッチはオフとした。研究は無作為比較前向き試験であった。
結果: 健常対照では相対的皮膚微小循環は34%増加 (P<0.001), 低RA活動性群では14%増加 (P<0.01) した。しかし, 高RA活動性群は有意の増加を示さなかった。血管壁振動数は低RA活動性群では17% (P<0.001), 高RA活動性群で13% (P<0.001) 増加し, 健常対照では有意の変動を認めなかった。皮膚温は高RA活動性群でごくわずか低下した程度で, 有意な変動は認められなかった。
結論: 今回の測定条件下では皮膚温の上昇は認められなかった。一方, 皮膚微小循環は健常対照と低RA活動性群では有意に増加した。低RA活動性群では高RA活動性群と比較し, 皮膚血流と血管運動に関しては超音波治療法が有用と思われた。

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気管支喘息28例を対象に, 年齢, 重症度, 気道過敏性, および Ca ionophore A23187 刺激時の白血球からのヒスタミン, ロイコトリエンC4, B4遊離と温泉療法の臨床効果との関連について検討を加えた。
1. 平均年齢は, 温泉療法無効例で, 有効例に比べやや低い傾向がみられた。
2. 白血球からのヒスタミン遊離は, 温泉療法無効例 (35.6±15.7%) において, 有効例 (著効例: 19.6±14.5%, 有効例: 19.3±12.2%) に比べ有意に高い値が示された (P<0.05)。
3. 白血球のLTC4産生は, 温泉療法有効例で, 無効例に比べ高い傾向がみられたが, 両群間に有意の差はみられなかった。
4. 白血球のLTB4産生は, 温泉療法有効例 (著効例: 12.9±13.3ng/5x10⁶cells, 有効例: 12.6±7.8ng/5x10⁶cells) で, (無効例: 7.8±5.8ng/5x10⁶cells) に比べ有意に高い傾向がみられた (P<0.05)。
5. メサコリンによる気道過敏性試験では, 温泉療法無効例で, 有効例に比べ, より強い気道過敏性が示されたが, 両群間には有意の差は見られなかった。
6. 温泉療法の効果と血中コーチゾール値との間にはなんらの関連もみられなかった。
以上の結果より, 温泉療法の臨床効果は, 白血球からのヒスタミンやロイコトリエンC4. B4遊離の程度とある程度関連があることが示唆された。

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We assessed the Master's single two-step test, postural blood pressure reflex, and autonomic nervous system manifestation in 112 essential hypertension patients and evaluated the results of low-frequency electroacupuncture therapy in 32 patients who exhibited the pressor type of diastolic blood pressure response to exercise.
The following conclusions were drawn from the results.
1. The diastolic blood pressure response to exercise was the pressor type in 60 patients (54%) and the depressor type in 52 patients (46%). By catagory, it was the pressor type in 40 (56%) of the 72 patients in the group taking antihypertensive drugs, and the depressor type in 32 (44%). In the group of 38 patients taking diuretics, it was the pressor type in 20 patients (53%). In the group of 40 patients not taking autihypertensive drugs, 20 patients each displayed the pressor-type response and the depressor-type response.
2. The group with a pressor diastolic blood pressure response to exercise had higher systolic pressure when seated at rest than the depressor group, and the extent of the rise in systolic pressure in response to the exercise load was greater. The extent of the decrease in systolic blood pressure immediately after standing up in the postural blood pressure response test was less than in the depressor group.
3. The incidences of edema of the lower extremities, coldness of the lower extremities, and other autonomic nervous system symptoms were higher in the group with the pressor diastolic blood pressure response to exercise than in the depressor group.
4. The results of low-frequency electroacupuncture therapy on the 32 patients in the group with the pressor diastolic blood pressure response to exercise showed a depressor diastolic pressure response to exercise in 23 of the patients (72%). The period of treatment until the transition to the decreased pressure period was 5.5 months. While no improvement in the extent of the rise in systolic pressure in response to exercise was observed in the depressor stage, an increase in the extent of the decrease in systolic blood pressure immediately after standing up was observed in the postural blood pressure response test.
From on the above results, it was found that some patients with pre-hypertension and mild hypertension showed the diastolic pressure response to the Master's single two step test that differed (in pressor type) from that of healthy subjects. In particular, it was shown that the blood pressure of some patients taking antihypertensive agents whose blood pressure was always within the normal range exhibited blood pressure responses to exercise that differed from those of healthy subjects. It was also found that 1-Hz, 10-minute low-frequency electroacupuncture therapy applied to the posterior surface of the leg (tibialis posterior muscle) is effective in normalizing the diastolic blood pressure response (shifting to the depressor type) to the Master's single two-step test in patients who displayed a pressor-type diastolic blood pressure response to exercise.

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We subjected six male lumbago patients (average age of 58.2 years) to underwater therapeutic exercise with and without a hydropower system (Flow Machine (FM)) twice a week for 4 weeks (a total of 10 hours) at an interval of 10 weeks between the two therapeutic sessions. The FM produced running water (average speed of 0.9meter/second) in a temperature-controlled pool. The water temperature was kept to about 30°C, The subjects received a total of four examinations before and after these two therapeutic sessions. We compared the results of these two therapeutic sessions (under-water therapeutic exercise with FM and without FM) and obtained the conclusions described below.
Improvements of obesity, anaerobic power, power around knee, vital capacity and total score in lumbago treatment (results of Japanese Orthopaedic Association) were observed more significantly (p<0.05) and rapidly with the use of FM than without FM. Further, increased HDL-cholesterol and decreased free fatty acid in blood were observed significantly (p<0.05) only for FM use.
It was suggested that the resistance of running water, vibratile massage effect, and heat action of produced supersonic waves promoted the above improvements. We concluded that the hydropower system was useful in underwater therapeutic exercise on lumbago patients.

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Prof. Motosaburo Masuyama has detailedly investigated the statistical distribution of more than 300 kinds of human biological traits, such as biochemical substances in blood. In his study, he found several empirical laws with respect to CV (coefficient of variation) of these traits, and proposed the two rules of human individual variability. The one was CV of fundamental blood components were less than 0.3, and another was the CV of these components did not differ by sex, race and age. In this paper, we first introduced his study. Second, we discussed the usefulness of his rules in the determination of initial dosis for patients with allergy. In addition, we tested the validity of his rules by using large size data obtained by the country-wide health check. We concluded that Masuyama's rules could apply many types of normal blood components of human being and be useful for designingg drug therapy, and for arranging clinical data. Since precise investigation performed by us showed that there are definite difference of CV between male and female, young and old, in many blood components, further study is needed.

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