We had designed Repetitive facilitation exercises (RFEs) using a novel facilitation technique and showen its promoting effects on the functional recovery of the hemiplegica. Balneotherapy (or spa therapy) for patients with disabilities is one of the most familiar forms of rehabilitative therapy. We applied balneotherapy or heat, vibratory sutimuli, Transcranial Magnetic Stimulation (TMS) in new manner or in combination with RFEs for patients with hemiplegia. We observed beneficial effects of balneotherapy on controlling the spasticity of hemiparetic limb, and on the quality of life in patients with disability stroke and orthopedic disease, in addition to beneficial effects on Adipo-cytokines. These studies will develop new effective neuro-rehabilitation and contribute to welfares of the people.