For the successful treatment of cancer of the cervical esophagus with normal functional restoration, it is extremely important to have a good team-work among otolaryngologists, general surgeons and plastic surgeons. The author tabulated some of the important points in the surgical treatment of the disease and discussed the following: 1. Effect of radiation and chemotherapy 2. Resection of the cervical lymph nodes 3. Preservation of the larynx 4. Preservation of the trachea 5. Treatment of the sternum in constructing a tracheostoma 6. Open chest surgery and total resection of the esophagus 7. Materials for reconstruction of the esophagus 8. Use of dertopectral flap 9. Grafting of a part of digestive tract.
The authors report on the results of a long term observation on 181 tonsillectomy cases as studied by means of questionnaires. The results showed favorable effect of tonsillectomy in most of the patients. The indication for tonsillectomy and the importance of postoperative observation are discussed.
The author reports 2 casee of candidasis of the paranasal sinuses. The first case is a 34-year-old female who showed toothache as an initial symptom, the second case is a 58-year-old female who had bloody sputum and the last case is a 31-year-old male who sought medical aid because of foul oder nasal discharge. The incidence of candidasis of the lung has been reported greater in male than in female. A search of pertinent literature failed to demonstrate the typical case in which excessive use of antibiotics or steroid caused candidasis of the paranasal sinus. The infection of candida usually occurs either as an aggresive type or as necrotic type. The process of candida infection in these three cases might be that candida in the air infected the pathological mucosa of the sinuses through the natural ostium.
Fundamental and clinical investigations with a new Cephalosporin C derivative, Cephalothin (CET) were performed with the following results: 1) In vitro antibacterial activity: The minimal inhibitory concentration of CET was measured by an agar plate dilution method. The MIC of CET against 80 strains of coagulase positive staphylococcus isolated from otorrhea was distributed over a range of ≤0.19 to 6.25 mcg/ml, with a peak being observed particulary at ≤0.19 mcg/ml. 2) Concentration in blood: The average maximal level reached 10.1 mcg/ml, 30 minutes after a single intramuscular injection of 500 mg to healthy adults, and the level was still 0.1 mcg/ml 6 hours after the injection. 3) Concentration in tissues: CET activity was demonstrable at the concentration of 0.4 to 0.7 mcg/g in a human palatine tonsil and mucous membrane from the maxillary sinus one hour after the intramuscular injection of 500 mg. Further, the serum concentration of CET was between 6.8 to 7.1 mcg/ml. 4) The results of treatment with intramuscular injection of CET in 30 cases of infections were excellent in 18 cases, good in 10 cases and fair in 2 cases. When the cases in which it was excellent and good were considered together, good results were obtained in 30 cases, or 93 per cent. 5) Side effect: No side effect was shown with the intramuscular injection of CET. An examination of hepatic function, electrolytes and auditory acuity before and after the injection showed no significant disturbance.