The treatment of maxillary sinus cancer is described historically, particularly about the position and value of the author's treatments. At present, the features of the author's treatment of maxillary sinus carcinoma is as follows: 1) Co-60 Gamma-ray irradiation of 5, 000 rad/25 fr/5 wks, 2) continuous intra-arterial infusion of 5-FU in a total dose of 2, 000 mg, 3) exposure and cleaning of the maxillary sinus, 4) cryqsurgery once a week, 5) curettage of necrotized masses a, 6) immunological therapy by. CWS, 7) maxillectomy when a recurrence is comfirmed, and 8) radical neck dissection for cervical metastasis. The results by survival rate has been improving and the number of maxillectomy has declined gradually. The 3-year-survival rate is around 60-65%, and the percentage of maxillectomy among the survivers is about 15%.
A case of malignant melanoma with wide hematogenic metastasis is reported. The primary lesion might be a pigment tumor in the nasal cavity originating in the left middle nasal turbinate. In this paper the enzymological, immunological and therapeutical aspects about malignant melanoma are described in comparison with a case experienced by us and other cases reported in the literature.
The authors report a case of submandibular cancer that showed unusually high CEA level, 7380-11500mg/ml, as measured by a Roche's kit. The extremely high level which could not be found even in literature might have been caused either by depressive action upon the reappearance of CEA due to the changes of the herediatary factors wrought by the cancer or increased excretion of CEA into the peripheral blood due to extensive systemic metastases of malignant cells with distorted hereditary factors. Taking into consideration the results of measurements of lymphocytes subpopulation, which was used as an immunological parameter, skin tests with PHA and PPD, and serum immunoglobulin levels, the authors could not rule out the presence of some relation between the CEA level and immunogenic function.
Although osteoma is seen occasionally in the frontal sinus its occurrence in the ethmoidal sinus is rare. The authors report a large osteoma of the ethmoidal sinus, which was associated with visual disturbance. A survey of 2, 500 randomly selected x-ray films of the paranasal sinuses taken at the Jikei University Hospital and its affiliated hospitals revealed 3 osteomas of the paranasal sinuses including the present case, which was 0.12% in incidence. The other two cases were osteomas in the frontal sinus. Diagnosis of osteoma can be made either by x-ray, CT scan or isotope study, or by combination of these studies. The present osteoma has been successfully removed by lateral rhinotomy with full recovery of the vision.
Cancer of the frontal sinus has been known for its rare occurrence and poor prognosis. The authors report a case of primary cancer of the frontal sinus in a 60-year-old male, that initially appeared to be a frontal sinus cyst which had probably been induced by a previous trauma to the frontal region. Exposure of the frontal sinus revealed a primary cancer of the sinus, histologically a squamous cell carcinoma. Postoperative irradiation is underway on this patient.