The Nagoya 1-60 strain of Sendai virus was noculated intranasally into the SPF mice. The pathology of the olfactory and respiratory regions were studied using histopathological observation and immunofluorescent antibody staining technique. The following results and conclusions were obtained. 1. Histopathologically, in five days after the inoculation of Sendai virus, severe damages with destruction of the ciliated epithelium was observed in the respiratory region. After ten days however only slight inflammatory changes remained. On the other hand, the olfactory region disclosed no remarkable inflammatory changes. 2. The appearance of immunofluorescence was most striking in the surface of the olfactory epithelium and the ciliated epithelium on days 2 and 3 after intranasal inoculation, and then it gradually subsided. 3. Considering these findings, there seems to exist the receptors against Sendai virus not only in the respiratory region but also in the olfactory region, therefore, Sendai virus can adhere and increase in the both regions. However, the olfactory region appeared more resistive to the pneumotropic virus, Sendai virus than the respiratory region.
In 29 cases of head and neck carcinoma, radical treatment was performed using three methods consisting Futrafur Suppository (FT-5) +radiotherapy (group 1), FT-S +radiotherapy + BLM, local or intravenous injection, (group 2) and FT-S+ radiotherapy +BLM intra-arterial infusion (group 3) to determine clinical efficancy of each treatment modality. Among the cases, 27 were evaluable. Primary effect was observed in 26 cases (96.3%) that received radical treatment. One case of group 3 showed no response and died. Local recurrence was observed in six cases (22.2%) in 3-14 months after the initial radical treatment. They were one cases of group 1. two of group 2 and three of group 3. Six cases who were two cases of group 2 and four of group 3 died of the diesease and one case died of a disease unrelated to carcinoma. Side effect due to the treatment developed in 11 cases (37.9%) out of 29 cases but severe side effect was not encountered.
School studies on changes of the tympanic membranes in children revealed a high incidence of abnormal findings in preschool children and a decreasing incidence of such abnormalities with the increase in age. A majority of preschool children showed abnormal findings of the tympanic membrane; retraction of the pars tensa, retraction of pars flaccida, redness, and clouding in the decreasing order. At ages 16 and 17, there was an increase in the incidence of retraction of the pars flaccida. Abnormal tympanograms were most frequent at age five and its incidence decreased with the increase in age. It was observed that the results of tymapnograms matched the findings of the tympanic membrane in an increasing number of cases as the children grew older. A certain parallel was seen between the frequency of abnormal findings of the tympanic membrane and that of the abnormal rhinological findings.
Observation of the tympanic membrane and mastoid cavity in children showed that the retraction of the tympanic membrane was related to the extent of the development of the mastoid cavity. The two age periods, 5-6 and 10-41, are the periods of acute development of the mastoid cavity which coincides with the period of aggravation of the infectious middle ear diseases probably due to poor ventilation of the enlarged mastoid cavity. The authors suggested that the findings that frequent occurrence of cholesteatoma in children are at ages 7 to 8 and 12 to 14 may also be related to the period of actue development of the mastoid cavity.
Abuse of antibiotics and steroid hormones may cause fungus infections of the nasal cavity and paranasal sinuses. Eleven such cases treated at the National Defense Medical College Hospital in the period of 1978 through 1983 are reported. The kinds of the fungus seen each year were different. The maxillary sinus was the most common site of the lesion. Ten cases occurred unilaterally and only one bilaterally. Seven cases presented necrotic granulation masses like a fungus ball in the middle nasal meatus. This can be considered to be a specific feature of the fungus infections of the nose. The treatment of choice is a surgical removal of the lesion which would ensue a good prognosis without resorting to the antifungal medication.
During the seven years from 1976 to 1982 ten cases of mental disturbances of organic or reactive cause were seen in the patients with head and neck malignacies at the Jikei University Hospital. One patient was in his fifties, three were in sixties and six were in seventies. Of the ten patients eight suffered from organic brain diseases such as metastases or brain atrophy while the remaining two suffered from reactive mental disorders. Surgery of the head and neck malignacies is often extensive and result in various disfigurements and disabilities. Causes of reactive mental disorders in such patients can be traced to the proclivities that 1. repeated operations often result in functional disturbances such as dysphagia, 2. such patients are usually advanced aged, 3. operations often leave discouraging disfigurement and 4. frequent persistent insomnia in the postoperative peiord. The author stressed that mental disorders should be prevented through thorough explanation on the surgical procedure and postoperative course prior to the surgery, careful postoperative evaluation of the mental status and prevention of insomnia, and that surgeons should make utmost effort to achieve an early discharge of the patients through the use of effective onestage reconstructive measures such as microvascular surgical techniques.
A 36-year-old woman noted a small painful hemangiomatous tumor on the dorsal surface of the tongue on July 17, 1983. It was broken off during her lunch on the day before her delivery. After the delivery, the tumor which appeared like a raspberry, reappeared at the same place and grew progressively up to a size of 29 mm×22 mm in a few weeks. Surgery was done on September 27, 1983. Pathological examination revealed a capillary hemangioma. From the clinical point of view, it was considered to be a pyogenic tumor. It is suggested that the hormonal change after pregnancy played one of the roles in the remarkable growth of the tumor in such a short period of time.