There are various new surgical methods which utilize physical energy. They have different features one another. For understanding of feature of each new method we made macro and microscopic examinations of the tongue of adult healthy dogs after each treatment with these methods. The specimens are examined at immediately after treatment, and 1, 2, 3 and 4 weeks after the treatment. These therapies are cryosurgery, bipolar coagulator method, infrared coagulator method, ultrasonic aspirator method, CO2LASER surgery, and NdYAG LASER surgery. Immediately after cryosurgery, we recognized redness, swelling, and induration, and under a microscope there were many intrastructual gaps from the mucous membrane to the muscular layer. We found tissue defect or deep excavation 1week after, and re-epithelization occured in 2 weeks. After bipolar and infrared coagulator methods, coagulation necrosis was remarkable, by which we could stop bleeding. Re-epitelization was found after 1 to 2 weeks. Abration, tissue defect and coagulation necrosis were recognized immediately after ultrasonic aspiration method. Tissue defect reached the muscular layer at a high output. Re-epithelization began in 2 weeks. At a small output and short radiating time of Nd-YAG LASER surgery, we found coagulation, and carbonization of the tissue, wheras tissue defect were remarkable at a high output and long radiating time. The tissue defect resulted in a large defect or perforation 1 week later, to that we must pay attention on clinical use. Re-epitelization was seen in 2weeks. Immediately after CO2 LASER surgery, carbonization and tissue defect increased its sphere according to the amount of output and radiating time. Re-epitelization occured a week later.
Recently, a computer system has frequently been used in the medical science. In the field of otoneurology the computer system has been employed for quantitative analysis of various parameters in the electronystagmographic (ENG) tracings of nystagmus or abnormal eye movement. The computer has been used for analysis of optokinetic pattern (OKP) test that is one of our routine examinations on patients with vertigo. This paper presents a new method of computer diagnosis of OKP test. Horizontal optokinetic nystagmus (OKN) induced in the modified OKP test is input as a signal wave to the computer system with the analog to digital converter the noise of the OKN is reduced by auto-corelation, and then a power spectrum is calculated from its signal wave using the fast Fourier tranform (FFT) or the maximum entropy method (MEM). The power spectra of 10 normal subjects and 67 patients were analyzed on a DEC PDP11/23 computer system. OKPs were classified into 5 groups by referring to their power spectra and cut-off point was set in each group by this autoanalysis system. Data in the computer system can be called out on demand and it takes less than one miniute to ask the power spectrum by using our auto-corelation and FFT program. MEM is logically superior to FFT in resolvability. However, there is basically not any difference between FFT and MEM in the case of which spectrum is gentle. It seems to be better to use FFT in the analysis of the OKP considering the display time. This new method is of practical use and can be expected to facilitate the more objective OKP diagnosis than the conventinal method. Especially it is useful to compare the OKP of both sides in a patient, to compare the OKP of each case with normal subject and to follow up the patient with the data of his OKP spectum.
Efficacy of lysozyme in experimentally induced sinusitis in rabbits was determined in a morphological study. Examination under light and scanning electron microscopes revealed a marked improvement in sinusitis in the group of rabbits treated with lysozyme chloride at a dose of 100mg/kg/day for one week, the rate of improvement being higher in the lysozyme group than in the control. The effect of combination therapy with lysozyme chloride and an antibiotic (Cefmenoxime) in human chronic sinusitis was also evaluated. The delivery of the antibiotic to the maxillary sinus membrane tended to be facilitated to a greater extent in the combination therapy group than in the group receiving the antibiotic alone, and a tendency was noted that the difference in drug delivery was statistically significant.