Nasal provocation test was evaluated by three characteristic symptoms, perennial sneezing, nasal obstruction and watery discharge.
In addition, we studied a method for quantitatively evaluating the response of the nasal mucous membrane to provocation using antigen disk, while nasal respiratory resistance was continuously measured by a rhinograph.
The response curve in the nasal respiratory resistance with provocation test was classified by the patterns into six types.
Also, we obtained three parameters as analysis of the response curve.
(1) Ta: This represents the duration for the beginning rise of nasal respiratory resistance in response to the provocation test, reflecting the degree of the sensitivity of the nasal mucous membrane.
(2) ΔRrs·N: This parameter is an inclination in rise when nasal respiratory resistance is increasing in the provocation test, and this can be calculated by the tan θ.
(3) Rrs·N: This is the value of the stable nasal respiratory resistanse within the initial one minute of the measurement.
In this paper, we examined the effect of autonomic nerve and antiallergic drugs in the allergic nasal mucosa by using Rhinograph.
The results were as follows,
(1) The α-adrenergic stimulant reduced reactivity and sensitivity of the allergic nasal mucosa remarkably.
(2) The β
2-adrenargic stimulant induced nasal obstruction.
(3) The cholino-reseptor antagonist produced no change in three parameters.
(4) All of antiallergic drugs were reduced reactivity and sensitivity of the allergic nasal mucosa remarkably, in addition further more topical steroids reduced nasal obstruction remarkably.
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