JIBI INKOKA TEMBO
Online ISSN : 1883-6429
Print ISSN : 0386-9687
ISSN-L : 0386-9687
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Volume 51, Issue 1
Displaying 1-9 of 9 articles from this issue
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FEATURE ARTICLE
  • RECENT ADVANCES IN RESEARCH OF ALLERGIC RHINITIS
    —PATHOGENESIS AND THERAPEUTIC APPROACH—
    Hideyuki Kawauchi, Noriaki Aoi, Shingo Kataoka, Akemichi Murata, Takay ...
    2008 Volume 51 Issue 1 Pages 8-25
    Published: 2008
    Released on J-STAGE: August 06, 2009
    DOIhttps://doi.org/10.11453/orltokyo.51.8
    JOURNAL FREE ACCESS
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    Allergic rhinitis is not a life-threatening disease, but its persistent symptoms disturb patient's daily life. Moreover, it could be a risk factor to elongate infective inflammations in upper respiratory tract such as otitis media with effusion or chronic rhinosinusitis. So called, "One airway, one disease" paradigm in ARIA (Allergic Rhinitis and its Impact on Asthma) report recently reminds us of the interaction in disease condition between lower respiratory tract and upper respiratory tract and the importance of therapeutic approach for downregulating allergic rhinitis. In this manuscript, we would like to briefly address a review on recent advances in basic and clinical research of allergic rhinitis.
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RESEARCH
  • EXPRESSION OF THE CYSTEINYL LEUKOTRIENES AND THEIR RECEPTORS IN THE NASAL POLYPS OF CHRONIC RHINOSINUSITIS PATIENTS WITH ASTHMA
    Tsuyoshi Yoshimura, Mamoru Yoshikawa, Nobuyoshi Otori, Shinichi Haruna ...
    2008 Volume 51 Issue 1 Pages 26-32
    Published: 2008
    Released on J-STAGE: August 06, 2009
    DOIhttps://doi.org/10.11453/orltokyo.51.26
    JOURNAL FREE ACCESS
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    Objectives: To examine the role of CysLTs in CRS, nasal polyp specimens were obtained from patients with CRS classified into 3 subgroups: those with aspirin-intolerant asthma (CRS-AIA group), those with bronchial asthma (CRS-BA group), and those without asthma (CRS-NA group).
    Design: Samples were prepared from the nasal polyps of patients undergoing endoscopic sinus surgery (ESS) at our hospital. The CysLTs were extracted using the C18 Sep-Pak column (Waters Corp, Milford, MA) and quantified using a high-sensitivity competitive EIA kit (Cayman chemical, Ann Arbor, MI) in accordance with the manufacturer's instructions. The expressions of the CysLT1 and CysLT2 receptors in the nasal polyp specimens were evaluated by immunohistochemistry.
    Subjects: Twenty-seven patients who had undergone ESS.
    Results: The concentrations of the CysLTs were significantly higher in the polyps obtained from the CRS-AIA group than in those obtained from the CRS-BA or CRS-NA group. There were no significant differences in the nasal polyp CysLT concentrations between the CRS-BA group and CRS-NA group. Expressions of both the CysLT1 and CysLT2 receptors were significantly more intense? stronger? higher? in the specimens from the CRS-AIA group than in those from either of the other two groups, while there were no significant differences in the expression levels of the CysLT1 and CysLT2 receptors in the nasal mucosal inflammatory cells.
    Conclusions: These results suggest that CysLTs may play prominent roles in the pathogenesis of aspirin-intolerant asthma associated with CRS.
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ORIGINAL PAPERS
  • TUBERCULOUS OTITIS MEDIA: CLINICAL ASPECTS OF 7 CASES
    Hiromi Kojima, Kazuhisa Yamamoto, Masahiro Rikitake, Nobumasa Yamaguch ...
    2008 Volume 51 Issue 1 Pages 33-42
    Published: 2008
    Released on J-STAGE: August 06, 2009
    DOIhttps://doi.org/10.11453/orltokyo.51.33
    JOURNAL FREE ACCESS
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    The clinical features of tuberculous otitis media have been changed. This study was undertaken to revise the diagnostic characteristics of tuberculous otitis media (TOM), a disorder that is often diagnosed at a relatively late stage, leading to delays in specific treatment. We reviewed a series of 7 cases of recently treated TOM. The mean patient age was 31.6 years, and most of the patients were women (female: male ratio, 6:1). Most patients showed intractable otorrhea, moderately severe hearing loss, and necrotic eardrums with single perforations. None of the patients had multiple perforations. Five patients had active pulmonary tuberculosis and three patients had epipharynx tuberculosis. Most cases of TOM that were caused by transmission via the Eustachian tube tended to resemble otitis media with effusion during the early stage of disease. Histological examination revealed tuberculous granulation, confirming the diagnosis in most cases. Temporal bone CT scans demonstrated relatively well-pneumatized mastoids and occupation in the soft tissue of the entire tympanum and mastoid air cells without bone erosion. Clinicians should have a high index of suspicion and should be aware of the clinical and radiological characteristics of TOM.
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  • A CASE OF RETROPHARYNGEAL ABSCESS CAUSING CARDIOPULMONARY ARREST
    Kousuke Yoshifuku, Hiromi Nagano, Yuichi Kurono
    2008 Volume 51 Issue 1 Pages 43-48
    Published: 2008
    Released on J-STAGE: August 06, 2009
    DOIhttps://doi.org/10.11453/orltokyo.51.43
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    In recent years, the incidence of retropharyngeal abscess has decreased with the development of effective antibiotics; however, the occurrence rate still remains high in adults due to with complications such as diabetes mellitus.
    A 57-year-old male was admitted to our hospital complaining of high fever, severe sore throat, pain upon swallowing, dysphagia and left cervical pain. ENT examination revealed swelling of the soft palate, deviation of the uvula to the right, and an inflammatory swelling of the left arytenoid. However, there was no evidence of airway obstruction.
    Based on these findings, the patient was diagnosed to have the lower polar type of peritonsillar abscess with acute lateral pharyngitis, which was considered as an indication for emergency surgery. While he waited for the surgery in the treatment room, the patient developed acute cardiopulmonary arrest. Transoral tracheal intubation and cardiopulmonary resuscitation were immediately performed, and a brain computed tomography (CT) was performed to exclude the presence of a brain disorder. The CT examination revealed a retropharyngeal abscess and a left peritonsillar abscess. After obtaining informed consent, tracheostomy, abscess tonsillectomy and intraoral drainage for the retropharyngeal abscess were performed under general anesthesia, followed by the administration of intravenous antibiotics together with human immunoglobulin. The patient's symptoms and clinical signs gradually resolved and he was discharged 23 days after the surgery without any complications.
    We wish to highlight the possibility of occurrence of abrupt airway obstruction in cases with retropharyngeal abscess and peritonsillar abscess and emphasize the need for careful observation using CT in these patients.
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  • A CASE OF MUMPS WITH LARYNGEAL EDEMA
    Toshiki Kobayashi, Yoshiyuki Hirazawa, Tomokatsu Udagawa, Hiroya Utaha ...
    2008 Volume 51 Issue 1 Pages 49-51
    Published: 2008
    Released on J-STAGE: August 06, 2009
    DOIhttps://doi.org/10.11453/orltokyo.51.49
    JOURNAL FREE ACCESS
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    We report a case of mumps who presented with laryngeal edema. The patient was a 23-year-old woman who visited a nearby hospital with complaints of pyrexia, neck swelling and dyspnea. She was referred to our hospital with a diagnosis of laryngeal edema. Because fiberoptic laryngoscopy revealed marked laryngeal edema, along with the clinical findings of swelling of the parotid glands and submandibular glands on both sides, we suspected that the patient was suffering from mumps associated with laryngeal edema. The patient was hospitalized and started on treatment with intravenous steroids and epinephrine inhalation. Since the laryngeal edema improved with these treatments, tracheotomy was not necessitated. The diagnosis of mumps was confirmed by the elevated serum antibody titers. There have been very few reports of mumps associated with laryngeal edema. However, it is essential to examine the airway by fiberoptic laryngoscopy in cases of mumps with swelling of the submandibular glands.
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