Extranodal NK/T-cell lymphoma, nasal type (ENKL), is a disease that mainly develops in the nasal cavity and or pharynx. Patients with ENKL do not manifest specific symptoms and often present with nasal obstruction and/or nasal bleeding. Therefore, the disease is often difficult to diagnose in clinical practice.
We report two cases of ENKL that we encountered recentry. The first patient was a 45-year-old man who presented with nasal obstruction. His nasal septum was hard, and many scabs adherent to the nasal mucosa were observed. We performed some examinations for example, histological diagnosis, however, no abnormalities were found. We decided to follow up the patient. Eight months after his first visit to our hospital, his rhinostenosis was getting worse. A tumor was found in his nasal cavity at neighborhood medical clinical. Therefore, he was referred to our hospital again and diagnosed as having ENKL (clinical stage IE, NK-IPI group1). He was administered chemotherapy, his response to which was judged as CR.
The second patient was a 49-year-old woman. She presented with worsening nasal obstruction and nasal bleeding and was referred by a neighborhood clinic to our hospital for nasal surgery. Her nasal cavity looked normal at first glance, however, careful examination revealed that her nasal mucosa was slightly hardened and hemorrhagic. CT revealed evidence of sinusitis. ESS was performed and biopsy specimens were obtained from multiple sites of the nose. Based on the findings, the patient was diagnosed as having ENKL (clinical stage IE, NK-IPI group1). She received chemotherapy, and showed improvement (CR). However, 5 months later, her general condition deteriorated and she died soon thereafter. The complete remission rate in patients with localized ENKL is higher than 50%. However, advanced ENKL is associated with a poor prognosis.
Therefore, this disease must be diagnosed early and treated promptly.
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