Recently, a considerable number of literatures are available as regards enzyme therapy for chronic sinusitis attracting concerns from many clinicians. The author, discussed several problems of enzyme therapy in which more room remains to be solved. In present paper, general outline has been given as regards historical background, literatures and mechanism of action of various enzymes for chronic sinusitis. Fundamental and clinical problems of newly introduced enzymes have also been discussed from author's point of view.
An attempt has been made by present authors to utilze polygraph which enables simulantaneous recording of EEG, Nystagmogram, respirogram ECG and GSR for objective determination of olfactory sensitivity. A total of 17 persons have been given an olfactory stimulation by local application of Alinamin (5mg.)-soaked nasal applicator as polygraph has been recorded in supine position with their eyes closed. Thus, each of these traces has been analyzed for the microlectectrical reactions induced by olfactory stimulations. The overall reaction rates amounted to 94.1% while the most reliable “on-off effect” observed in 70% of the cases. In this study, the reaction rates are most frequent in polygraph and GSR, EEG, respirograph, nystagmogram then ECG followed in the order of lesser reacting frequency. As regards “on-off effect”, polygraph showed the highest reaction rates and GSR, EEG, respirophonogram, nystagmogram, ECG followed in the order of lesser frequency of the reactions.
Two cases of skull fractures involving paranasal sinuses either caused by traffic accidents were presented. The first case is a 55-year-old male who has been hit by a train causing him the severe fractures of the right frontal bone involving right frontal sinus associating an epidural hematoma. The second case is a 35-year-old male sustained, the extensive fracture of the base of the skull with contusion of bilateral ethomoid, cells and right eye ball, there was an extensive dural exposure at the anterior cranial fossa accompanied by a brain hernia. Either of the cases has been treated successfully by the joint efforts of otolaryngologists and neurosurgeons. Discussing these cases from various points of views, authors concluded as follows: The treatment of the skull fractures involving the paranasal sinuses should be carried out with special attention to the paranasal sinuses and the thorough debrigdement of the presumably infected tissues is necessary for the benifit of averting the impending intracranial complications, and this can be done most efficiently by adopting a lateral rhinotomy. Comment is also, made. about the use of tracheotomy in skull, fractures.
Present authors reported two cases. of rhabdomyosarcoma in children, which is of rare occurrence also in the field of otorhinolaryngology. One of the cases encountered in a 6-year-old male in whom the tumor responded strikingly to radiation therapy so impressing the authors an eventual success in treatment. Regretably however, the tumor showed an inveterate recurrence ten months after the conclusion of the treatment. The authors added another case of 8-year-old female seen at the Japan Cancer Institute. Literatures were reviewed and some discussions were made on this disease.
A total of 56 patients, each suffering from 8 different acute inflammatory lesions in the ear nose and throat, have been treated with Kanacillin (a blend of Kanamycin and Penicillin) at the Sapporo Teishin Hospital, then the datas obtained have been summalized as follows: Of 56 cases, marked improvement of the findings observed in 26 cases (46%) improvement in 27 cases (48%) slight improvement in 2 cases (4%) and fail in 1 case (2%). From these results, the efficacy of this drug may be said to be 94% as former two combined. No singnificant complication attributable to this drug has been encountered all through the treatment. Studying these datas, author concluded Kanacillin is a potent and recommendable preparation to be used in acute inflammatory lesions in otorhinolaryngology.
A rare case of esophageal tumor of which diagnosis failed to be reached by repeated X-ray examinations and esophagoscopy because of unusual manifestations has been described. The postmortem examination revealed a malignant neurogenic tumor, neuroblastoma of the esophagus, which is of rare occurrence in Japan as well as in other countries. As for the primary site, however, no definite information was available.