By means of comparing the histopathological changes of the mucous membrane in the nasoparanasal cavities between germ free animals and and ordinary animals, a study was made to find the entity of the function of the nasoparanasal mucous membrane, The results indicated the followings: 1. A definite reduction in weight of the mesenteric lymphnodes was observed in germ free animals. 2. The gnotobid animals revealed negative agglutination titer for Proteus mirabilis, The titer for serum r-globulin was found to be one half of the contrast group. 3. In gnotobid animals, the histopathological findings indicated a pronounced tendency of epithelium to remain monolayer associated with a deminishing evidence of hyalinization. 4. A depressed formation of the secondary lymphnodules has been noticed in germ free animals. The author concluded that the postnatal morphlogical changes of the nasoparanasal mucous membrane is not created only by passive resistance to the pathogenic microorganisms but also by an active reaction to the bacteria, where the regional changes of the mucous membrane is the result of duplicated effect, one is the regional reaction to the microorganisms and the other is the rebound effect of systemic reaction on the mucous membrane.
A slightly retracted nodular induration was observed in the oral cavity of a 39 years old Japanese female. This lesion located submucously in left buccal region was noted two months prior to the initial visit because of mild pain. Diagnosis was made after surgical removal of the horse bean sized lesion, through a mucobuccal incision (on Nov. 17, 1962). Histopathological diagnosis was fibrous granuloma of tuberculous origin, well encapsulated and considered inactive. Medical history of this patient revealed numerous tuberculous diseases since her childhood, including pulmonary infiltration, tuberculous peritonitis and caries of the lumbar spine. X-ray diagnosis verified this past history. It is assumed that the lesion had developed into the buccal mucosa hematogenously during active stage of tuberculosis in childhood around 13 years of age. This nonulcerative lesion apparently remained asymptomatic for over 25 years. A rare case of atypical tuberculous granuloma in the oral cavity was reported.
A long term postoperative radiographic follow up of 90 cases with frontal sinusectomies has been performed by present author. Of 90 cases, in 26 cases or 30% the contralateral frontal sinus was found to have enlarged postoperatively by an area more than 30% as measured on the X-ray films. It has been documented that those enlarged sinuses are easily accesible to infection, and some comments were made on etiology of the postoperative enlargement and on preventive measures of the enlargement.
In 1939, Wassmund reported a theory that genyantritis would seldom be caused by alveoler blennorrhea. In 1940, Morimoto shad entertained a doubt about the truth of the Wassmund's theory, and was able to cite as many as three clinical cases of genyantritis which were believed to be resulted from the alveolar blennorrhea in half a year. Thus, the professor established a new theory opposing the Wassmund's theory. Within ten subsequent years, Horiguchi and' Miura submitted a report on the same subject at the 51st Otorhinological Convention, and at present, dental genyantritis is frequently reported in the same manner as previonsly suggested by Morimoto. In view of the circumstances, the writer wishes to present a report on two more cases of dental genyantritis observed during the past half a year, in support of Morimoto's theory and as a token of his feeling of respect and admiration to the approbation of Morimoto, who was then courageous enough to refute the theory advanced by Wassmund.
The author has conducted a sensitivity study on bacteria isoiated from the otorrhea of infected ears to found that Colistin and Streptomycin either of which has been so far used exclusively for gram-negative microorganisms has considerable bacteriostatic or bacteriocidal effect even in some of gram-positive bacteria. The clinical application of these drugs, according to the results of sensitivity test, to gram-positive bacteria was suggested to be of value in some cases.
A series of 40 patients with chronic sinusitis have been treated conservatively by a proeolytic agent, Minatohl-P, to yield a result: marked improvement in 8 cases or 20%, moderate improvement in 11 cases or 27.5%, minimal improvement in 8 cases or 20% and fail in 13 cases or 32%. In alleviation of subjective symptoms, a tendency was observed inwhich hyperrhinorrea improved first then followed by amelioration of nasal obstruction and postnasal discharge. An objective evaluation has failed to reveal obvious reduction of hypertrophied turbinates however, the authors confirmed a reduction of nasal poly in two of the cases. Although antral punctures revealed qulitative and quantitative improvement of the antral contents, no evident improvement has been recognized in radiographic pictures. Urticaria was seen in one of the cases as a possible complication of the drug.
The authors reported a case of 32 years old female with a metastatic tumor in the left temporal bone which occured two years and three months after the surgical treatment to the primary site, the uterus. An extensive review has been made on the incidence of metastatic tumor in the temporal bone inclusive of the auditory organ.