Recent evidence suggests that periodontal status, serum antibody levels for periodontopathic bacteria, and general health conditions are linked. Subjects over the age of 40 years (n=650) were recruited for the present study. Periodontal status was evaluated using the Community Periodontal Index of Treatment Needs (CPITN). The following characteristics, assessed during a general health examination, were used in the analysis: age, gender, body mass index (BMI), systolic and diastolic blood pressure (SBP, DBP), levels of alkaline phosphatase (ALP), total cholesterol (T-CHO), high density lipoprotein cholesterol (HDL-CHO), triglyceride (TG), fasting blood glucose (FBG), c-reactive protein (CRP), white blood cell counts (WBC), platelet counts (PLT) in the peripheral blood, smoking habits, amount of smoking (packsyear), and electro-cardiogram (ECG) rank. The serum IgG antibody titer for
Porphyromonas gingivalis fimbriae (IgG.
Pg. Fim.), the serum IgG antibody titer for
P gingivalis whole cell antigens (IgG.
Pg. whole), and the serum IgG antibody titer for
Actinobacillus actinomyceterncomitans whole cell antigens (IgG.
Aa. whole) were determined in each subject using an enzyme-linked immunosorbent assay. The subjects were divided into 4 different periodontal groups according to their maximum CPITN codes (0/1/2, 3, 4 or missing sextant (MS) subjects). The mean SBP, DBP, TG, WBC, and IgG.
Pg. Fim. were significantly higher in the CPITN 4 group than in the CPITN 0/1/2 group. The mean DBP and IgG.
Pg. Fim. were significantly higher in the CPITN 4 group than in the CPITN 3 group. Logistic regression analyses performed for 528 subjects (excluding the CPITN MS group) suggested significant associations between CPITN 4 subjects and (males OR: 2.27), smoking habit (OR: 2.36), a high DBP (OR: 1.62), a high WBC (OR: 1.38), a high IgG.
Pg. Fim. titer (OR: 1.20), a high IgG.
Pg. whole titer (OR: 1.55), and a high IgG.
Aa. whole titer (OR: 1.45). These results suggest periodontal status, gender, smoking habits, DBP, WBC, IgG.
Pg. Fim., IgG.
Pg. whole and IgG.
Aa. whole were significantly associated in the population that was examined. J Jpn Soc Periodontol, 45: 74-82, 2003.
View full abstract