In order to assess the syntenic relationship of genes in the laboratory rat (
Rattus norvegicus) and mouse (
Mus musculus), rat gene mapping is undertaken in rat-mouse somatic cell hybrids with the rat chromosome segregation. The genes coding for adenylate kinase-2 and phosphoglucomutase-2 are syntenic with enolase and phosphogluconate dehydrogenase, and assigned to rat chromosome 5. The four genes are syntenic in man and mouse, suggesting the conservation of the linkage relationship of homologous genes in the three divergent species.
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