Effect of aldosterone on T
3-binding to the nuclear fraction of the tail of toad tadpoles was investigated
in vitro. T
3-binding was increased by adding aldosterone to the incubation medium. Scatchard analysis revealed that aldosterone (3.4×10
-6M) increased the maximum binding capacity by 40% and that the steroid scarcely affected the value of dissociation constant. Elevation of thyroid hormone sensitivity in the presence of corticoids seems to be closely related to the corticoid-induced increase in nuclear binding capacity for thyroid hormones.
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