The dose-related increases in the SCE frequencies are observed in murine bone marrow cells treated by vinyl acetate in vivo. No differences are found in the augments of the SCEs between the hepatectomyzed and non- hepatectomyzed groups. No cell cycle delays are indicated in the treated groups.
Effects of MPTP and MPP+, potent dopaminergic neurotoxins, on the activity of NADH-ubiquinone oxidoreductase were studied using isolated mitochondrial preparation from C57BL/6J mouse brains. Both MPTP and MPP+ dose-dependently inhibited activity of NADH-ubiquinone oxidoreductase, however, MPTP found to be a more potent inhibitor compared with MPP+. Significance of these findings was discussed with regard to the mechanism of MPTP-induced neuronal degeneration.
Effect of piroheptine, an anticholinergic agent having a dopamine- uptake inhibiting property, on MPTP-induced striatal loss of dopamine was studied in C57BL/6J mice. Pre-treatment with piroheptine almost completely prevented loss of Striatal dopamine in MPTP-injected mice. Piroheptine is another agent which prevents MPTP neurotoxicity.