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Volume 63, Issue 4
Displaying 1-6 of 6 articles from this issue
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Yoshio FUJITA1987 Volume 63 Issue 4 Pages 111-114
Published: 1987
Released on J-STAGE: October 10, 2006
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Teiichi KOBAYASHI, Takashi HAMADA1987 Volume 63 Issue 4 Pages 115-118
Published: 1987
Released on J-STAGE: October 10, 2006
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Teiichi KOBAYASHI1987 Volume 63 Issue 4 Pages 119-122
Published: 1987
Released on J-STAGE: October 10, 2006
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The Developments of the Japanese Islands VToshio KIMURA1987 Volume 63 Issue 4 Pages 123-126
Published: 1987
Released on J-STAGE: October 10, 2006
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Takeshi TABIRA, YAO Da-Lin, Takashi YAMAMURA, Takaaki AOYAGI1987 Volume 63 Issue 4 Pages 127-130
Published: 1987
Released on J-STAGE: October 10, 2006
JOURNAL FREE ACCESSBactobolin, a novel antineoplastic and antibiotic, was tested for prevention and treatment of experimental autoimmune encephalomyelitis (EAE) in Lewis rats. Clinical and histological signs of EAE induced by active challenge with myelin basic protein and Freund's complete adjuvant were profoundly suppressed by prophylactic treatment with bactobolin during the inductive phase of EAE in association with diminished lymphocyte proliferative response to sensitized antigens. It was also effective on the effector phase of actively induced EAE as well as passively induced EAE with primary cultured spleen cells sensitized to myelin basic protein. Moreover, therapeutic administration of bactobolin after onset of EAE was effective. The results suggest possible usefulness of bactobolin for treatment of autoimmune disease.View full abstractDownload PDF (407K) -
Consistent with the Bone-Muscle Imbalance Hypothesis for the PathogenesisTsuyoshi TOTSUKA1987 Volume 63 Issue 4 Pages 131-134
Published: 1987
Released on J-STAGE: October 10, 2006
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