Proceedings of the Japan Academy, Series B
Online ISSN : 1349-2896
Print ISSN : 0386-2208
94 巻 , 8 号
選択された号の論文の1件中1~1を表示しています
Review
  • Shun KOIZUMI, Jun HAMAZAKI, Shigeo MURATA
    2018 年 94 巻 8 号 p. 325-336
    発行日: 2018/10/11
    公開日: 2018/10/11
    ジャーナル フリー HTML

    The 26S proteasome is a large protease complex that selectively degrades ubiquitinated proteins. It comprises 33 distinct subunits, each of which differ in function and structure, and which cannot be substituted by the other subunits. Owing to its complicated structure, the biogenesis of the 26S proteasome is elaborately regulated at the transcription, translation, and molecular assembly levels. Recent studies revealed that Nrf1 (NFE2L1) is a transcription factor that upregulates the expression of all the proteasome subunit genes in a concerted manner, especially during proteasome impairment in mammalian cells. In this review, we summarize current knowledge regarding the transcriptional regulation of the proteasome and recent findings concerning the regulation of Nrf1 transcription activity.

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