The marked hypoglycemic activity of the mesoxalate as observed in August and September was reduced to a vastly lesser degree in the dogs kept outdoors in the winter experiment. In November and December the drug did not cause such a marked decrease in the blood sugar as in summer.
But when the dogs were transferred from outdoors to the animal stockroom, maintained at a temperature of 27°C±2, the action of the drug returned to almost the same level displayed in the summer experiment. In January and February which have the lowest temperatures in Tokyo, hypoglycemia did not occur even after 6 weeks' protection from the cold air. Further, the May and June experiments showed results identical with those of the January and February experiments.
After unilateral adrenalectomy a striking hypoglycemia was seen in November and December but not in January and February. Bilateral adrenalectomy was necessary to induce a marked hypoglycemia in this coldest period of the year. Moreover, the increased resistance against hypoglycemia did not appear to diminish in the March-June experiments, even in the case of the unilateral adrenalectomized dogs. It is interesting to note here that the March-June temperatures in Tokyo are far higher than in November and December. The results of the July experiments, however, showed that the intensity of the hypoglycemia induced by the drug almost equalled that observed in August and September. On the other hand, in July, August, and September a certain amount of preadministered cortisone or ACTH clearly served to prevent marked hypoglycemia induced by the drug.
It has already been proved that hyperfunction of the pituitaryadrenal cortical system positively occurs when non-hibernating animals are exposed to low temperatures. Our experiments suggest that by means of continuous infusion with sodium mesoxalate into the pancreatic circulation the fluctuations in the function of the pituitary-adrenal cortical system can roughly be indicated quantitatively.

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1) The agglutinability of human cells increases with growth reaching the maximum at 30-34 and declines gradually thereafter.
2) The agglutinability of AB-type human blood cells is lower than that of A-type or B-type blood cells.
3) From the results of our experiments, it is considered that man matures fully in physical strength at 30-34 years and his senilismus begins after this age.

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In Salmonella B group several kinds of symbiotic phage are demonstrated, of which the iota phage governs the production of somatic antigen 1. When a strain without antigen 1 acquires lysogenicity by the infection with this phage, antigen 1 is produced in it. Consequently, it was considered to demonstrate that the symbiotic phage itself governs the genetic properties of the bacterium similarly as in the case of the antigenic transformation from 3, 10 to 3, 15 in Salmonella E group (Iseki and Sakai, 1953) and of toxin production in Corynebacterium dyphtheriae (Freeman, 1951).

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1. An enzyme derived from Bacillus fulminans decomposes not only O but also T substance, which is in non-secretor, demonstrated by anti-T precipitin in chicken serum and considered to be identicalwith Le^a substance reported to be contained in blood cells and saliva.
2. This enzyme diminishes the levorotatory rate of O as well as T substance and separates L-fucose, thus causing their group specificities to disappear.

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