1) The inhibiting activity of N-acetyl-D-galactosamine, its several derivatives, D-galactose, D-galactose-containing sugars and various other simple sugars was investigated in the three agglutination systems of human B, A, and O cells by the anti-B, anti-C(A+B), and anti-O(H) lectins, respectively, of
Sophora japonica L. seeds. 2) The inhibition data indicated directly that the serologically responsible structure of N-acetyl-D-galactosamine and D-galactose must be the pyranose form. 3) No significant difference in the inhibiting activity was noticed between the three forms, α-, β-anomeric derivatives and free form, of the pyranose structure of N-acetyl-D-galactosamine, but some differences were found in the activity between those three forms of D-galactose. In the later, β-anomeric derivative was more active than the others.4) The inhibiting activities of each serologically active sugar did not differ remarkably against the three specific lectins.5) Immunochemically significant structures of simple sugars in the interactions between the active sugars and the lectins were discussed.
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