A simple method is described of differential staining of parental chromosomes in human-mouse, dog-mouse, and rat-mouse hybrid cells, with a mixed solution of QM and 33258 Hoechst. This technique allows not only the discrimination of parental complements by bright centromeric bands specific for the mouse chromosomes, but also simultaneous identification of individual chromosomes by their characteristic Q-band patterns.
This paper reports clinical and cytogenetic features of a presumable reciprocal translocation between no. 1 and no. 17, or t(1p-; 17q+), found in a boy with gingival fibromatosis. Karyotype 46, XY, t(1; 17) (p31; q24) was given to this patient. His parents and two sisters are clinically and karyotypically normal.
Two cases of acute myeloblastic leukemia are described, in which a consistent chromosome abnormality showing a (9q+; 22q-) translocation was detected by banding analyses.