Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
Search
Advanced search
OR
Browse
Search
Volume 35, Issue 2
Displaying 1-16 of 16 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Contents
  • Electrically evoked responses in normal and blind eyes
    RAN HATAYAMA, KENJI YANASHIMA, AKIRA NAKAJIMA
    1989 Volume 35 Issue 2 Pages 171-175
    Published: July 30, 1989
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.35.171
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    To investigate the possibility for clinical use of a light-sensitive prosthesis, electrically evoked responses (EER) were evaluated in normal and blind eyes using cornea cutaneous, cornea-conjunctiva and conjunctiva-conjunctiva electrodes. Normal eyes exhibited similar EER patterns with the different stimulating electrodes. No phosphene or EER was detected in the eyes blind from various causes. An electrically palpitative sensation could be induced in blind eyes by a stimulating current. Determination of EER was considered to be useful for evaluating light-sensitive prostheses.
    View full abstract
    Download PDF (814K)
  • Correlation between the hyperproduction of glomerular extracellular proteins and the progression of glomerular lesion in IgA nephropathy
    MASAHIRO TAKEDA, YASUHIKO TOMINO
    1989 Volume 35 Issue 2 Pages 176-187
    Published: July 30, 1989
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.35.176
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Immunofluorescence, light and electron microscopic examinations were carried out to clarify the relations between the progression of glomerular lesion and the changes in the amount and distribution of glomerular proteins, such as 7S and non-collagenous (NC-1) domain of Type IV collagens, laminin (LN), and fibronectin (FN), and of IgA deposits in patients with IgA nephropathy. The intensity and distribution of these extracellular proteins were similar between the glomeruli from normal individuals and patients with IgA nephropathy at stages of “minimal” to “slight” lesions. In “moderate” to “advanced” stages of IgA nephropathy, the amount of FN, which is normally distributed only in the glomerular mesangium, was increased in the mesangium with FN being observed along the glomerular capillary walls. An increase in the amount of 7S domain of Type IV collagen and LN was also observed mainly in the subendothelial portions of the diseased glomerular capillary walls, and to a lesser extent in the mesangial areas. The NC-1 domain of Type IV collagen and glomerular basement membrane (GBM) substance, detected by serum autoantibodies from patients with Goodpasture's syndrome, did not show any changes and were distributed only along the GBM in IgA nephropathy as in normal subjects. It appeared that Type IV collagen, LN and FN detected in the glomeruli were not associated with IgA deposits in IgA nephropathy as determined by double immunofluorescence and acid-buffer elution studies. In conclusion, hyperproduction of these extracellular matrix proteins mainly in the glomerular mesangium is closely related to the progression of glomerular lesions in patients with IgA nephropathy.
    View full abstract
    Download PDF (3366K)
  • Fundamental and clinical studies on endometriosis
    SUMIE YUKAWA
    1989 Volume 35 Issue 2 Pages 188-197
    Published: July 30, 1989
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.35.188
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Fundamental and clinical studies were performed on 718 cases of endometriosis. Endometriosis occurred in the myometrium in 59.8 % of the cases, and in the ovary and serosa in 25.2% each, with 15% of the cases showing multiple involvement. In younger patients, the incidence of endomertriosis was higher in the ovary and serosa than in the myometrium. Although the histological findings in myometrial endometriosis were similar to those in the orthotopic endometrium, marked tissue destruction was noted in many cases of ovarial and serosal endometriosis. Estrogen receptors were detected in the nucleus in all orthotopic endometrium in the proliferative stage, but the percent positivity was 56 % in myometrial endometriosis. No estrogen receptors were detected in the ovary or serosa.
    View full abstract
    Download PDF (3712K)
  • Masculinization of the mouse submandibular gland and adrenal X-zone : Effect of ovariectomy
    SACHIKO MATSUURA
    1989 Volume 35 Issue 2 Pages 198-211
    Published: July 30, 1989
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.35.198
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    The changes in submandibular glands following ovariectomy were studied ultrastructurally, morphometrically and immunohistochemically. In the granular convoluted tubule (GCT), which is sexually dimorphic and sensitive to androgen, a marked increase of secretory granules was observed ultrastructurally 4 weeks after ovariectomy. Furthermore, its histological appearance became almost identical to that in males 12-16 weeks after ovariectomy, and the percentage of GCT in the gland reached the male level. The granules immunoreactive for nerve growth factor (NGF) antibody were increased in the GCT of ovariectomized mice. These findings suggest that GCT is stimulated by androgenic substances in ovariectomized mice. Morohometrical analysis revealed a significant increase in the volume of the X-zone of the adrenal cortex (the possible site of adrenal androgen secretion in mice) in these ovariectomized mice. Histochemical studies suggested that 3β -hydroxysteroid dehydrogenase activity also increased in the X-zone after the castration. These results suggest that alterations in the hormonal environment following ovariectomy increase steroid production, presumably adrenal androgen, in the adrenal cortex. This may cause the masculinization of the submandibular glands in the ovariectomized mice.
    View full abstract
    Download PDF (7003K)
  • Clinico-pathological study on the treatment of hepatocellular carcinoma
    MASAFUMI SUYAMA
    1989 Volume 35 Issue 2 Pages 212-218
    Published: July 30, 1989
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.35.212
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Liver function, therapeutic modarity and survival were analyzed in 415 cases of hepatocellular carcinomas to clarify the most suitable treatment. Seventy tumors were resected and the cumulative 3-and 5-year survival rates were 32% and 15%, respectively. Transcatheter arterial embolization (TAE) was performed in 159 patients, and their 3-year survival rate was 12%. In 68 patients, a cytostatic drug (20mg Mitomycin C) was injected into the hepatic artery, the 2-year survival was 26%. Generalized chemotherapy was performed in 118 patients, and the 2-year survival rate was 11%. Liver function was the most important factor for the survival of the patients with HCC. The results indicate that TAE is the treatment of choice for patients with unresectable tumors.
    View full abstract
    Download PDF (816K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top