Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 39, Issue 2
Displaying 1-21 of 21 articles from this issue
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Contents
  • Study on CT changes in autistic children
    -anatomical correlation of the damaged brain and delayed of psychomotor development-
    KATSUMI YAGUCHI
    1993 Volume 39 Issue 2 Pages 176-184
    Published: June 20, 1993
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.39.176
    JOURNAL FREE ACCESS
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    Since 1979 we have performed CT examinations on 132 autistic children. Neurological diagnosis of the lesion was established by Dr. Segawa's group. On the CT of many autistic children, we found a small low density change located in the anterior wall of the temporal horn, or localized dilatation of the inferior horn near the damaged brain. We reviewed 96 of these patients which all had the obvious low density changes, or localized irregular dilatations in the anterior wall of the temporal horn. By measureing the distance of damage from the midline, we divided the 96 cases into two groups. Group 1 consisted of those with damage located laterally more than 30mm line from the midline. Group 2 consisted of those with damage medially to the 30mm line from the midline. Those cases with, a large lesion both laterally and medially of the 30mm line, were categorized into group 1. In the adult brain the lateral border of the amygdaloid nucleus was never located laterally more than 30mm from the midline. Laterally over the 30mm line there were two marked fiber systems running near the anterior wall of the temporal horn: the fiber of the anterior commissure and the uncinate fascicle. Group 1 consisted of 62 patients and group 2, of 34 patients. The majority of the group two patients were pure autism children. This suggested that the main lesion in autism was in the amygdala.
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  • Interleukin-1 activity in urine of patients with bladder tumor
    KISABURO HANAZAWA
    1993 Volume 39 Issue 2 Pages 185-190
    Published: June 20, 1993
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.39.185
    JOURNAL FREE ACCESS
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    Interleukin-1 in urine samples from patients with bladder carcinoma was measured to investigate the correlation between interleukin-1 and urothelial neoplasmas. Nineteen patients with bladder carcinoma, 2 patients with cystitis, 2 patients with hematuria for benign prostatic hypertrophy and 6 healthy donors participated in this study. Urine specimens were clarified by centrifugation at 2000×G for 30 min and were concentrated 10-fold and 50-fold on PM-10 membrane. Enzyme-linked immunosorbent assays were used for the analysis of interleukin-1. The interleukin-1 titers in the urine of patients with cystitis and hematuria for benign prostatic hypertrophy were increased compared to those of healthy donors. Therefore, urine specimens from patients with bladder carcinoma only were separated from those who had cystitis and hematuria as well. The interleukin-1 titers in the urine of patients with bladder carcinoma were increased compared to those of healthy donors and progressed with tumor size. Although the interleukin-1 producing site has not been elucidated yet, our study suggests that interleukin-1 is produced by the tumor cells.
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  • Photodynamic effect on mouse urinary bladder cancer with the combination of pheophorbide a and Nd:YAG laser
    MASAMI MURATA
    1993 Volume 39 Issue 2 Pages 191-199
    Published: June 20, 1993
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.39.191
    JOURNAL FREE ACCESS
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    To develop a new therapeutic modality for urinary bladder cancer, we tested the photodynamic effect of a combination of pheophorbide a and Nd: YAG laser, with in vivo and in vitro studies, using transplantable mouse urinary bladder cancer MBT-2. In the in vivo study, a large necrotic area was observed macroscopically and microscopically after treatment. The in vitro studies revealed that this tumor killing effect was mainly photodynamic and not solely thermal. The intensity of this photodynamic effect was dependent on several factors, including concentration of pheophorbide a, time of contact with pheophorbide a and amount of laser energy. Pheophorbide a alone seemed to have no tumorcidal effect. These results show that the combination of pheophorbide a and Nd: YAG laser had definit antitumor effects against mouse urinary bladder cancer. These effects seem to be mainly derived from photodynamic reaction.
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  • Clinicopathological study on the lymph node metastasis of the depressed type early gastric cancer with special reference to the accompanying gastric ulcer
    MOTOKI NAKATSU
    1993 Volume 39 Issue 2 Pages 200-208
    Published: June 20, 1993
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.39.200
    JOURNAL FREE ACCESS
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    Lymph node metastasis is a serious problem in performing reduction surgery for early gastric cancer. To determine the influence of accompanying ulcers on lymph node metastasis in depressed type early gastric cancer, a clinicopathological study was conducted by dividing the ulcers in cancer lesions into four types : UI (-), UI-II, UI-III, and UI-IV, in accordance with Murakami's classification. The invasive patterns of these cancers in the submucosal layer were assessed in four categories : minute, scattered, diffuse, and massive. Cancers which did not invade beyond the mucosa had no lymph node metastasis. Tiny cancers with a diameter of less than 1.0cm also had no lymph node metastasis. Small cancers (from 1.0cm to 2.0cm in diameter) had lymph node metastasis only when ulcers were present within the cancer lesions. Large cancers with a diameter of 5.0cm or more had a high incidence of lymph node metastasis (45.5% for UI-III and 50.0% for UI-IV). Even when lymphatic invasion was negatiave, lymph node metastasis was positive when ulcers were present within the cancers. In cancers showing a minute or scattered invasion pattern, lymph node metastasis was sometimes positive if ulcers were present within the cancer lesions, particularly for those in groups UI-III or UI-IV. Lymph node metastasis was always positive in cancers showing diffuse invasion of the submucosal layer in group UI-III, and those showing scattered or diffuse invasion in group UI-IV.
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  • Electroencephalogram and antiepileptic drug therapy in postoperative intracranial meningioma
    MASAHIRO TSUJI, SHIGEKO SHINOMIYA (OKADA), KIYOSHI SATO
    1993 Volume 39 Issue 2 Pages 209-224
    Published: June 20, 1993
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.39.209
    JOURNAL FREE ACCESS
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    We studied the risk factors for postoperative seizures in 32 patients with meningioma and investigated indications for discontinuing antiepileptic drugs (AED) by longitudinally evaluating pre-and postoperative EEG findings (including frequency analysis) as well as other factors. The period of postoperative follow up ranged from 6-months to 7-years. In 9 patients (28.1%), EEGs were normal or showed only mild abnormalities, and the peak of the alpha band range was increased 2-months after surgery. AED therapy was discontinued at that time and EEG showed a stable pattern thereafter without clinical seizures. Three patients (9.4%) had clinical seizures. The risk factors for postoperative seizures were poor EEG prognosis, postoperatiave brain edema, and failure to administer AED, or inappropriate timing of discontinuing AED.
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  • Studies on the mechanism of thrombocytopenia observed in murine systemic lupus erythematosus
    TAKEHIRO SAIKAWA, MASATO FUJIMORI, HIROAKI KAWANO, REIKO SANOKAWA, SAC ...
    1993 Volume 39 Issue 2 Pages 225-234
    Published: June 20, 1993
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.39.225
    JOURNAL FREE ACCESS
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    Thrombocytopenia associated with systemic lupus erythematosus (SLE) may be due either to the production of platelet binding autoantibodies or to thrombosis, both frequently observed in SLE. The thrombosis in SLE is generally associated with the appearance of and phospholipid antibodies, especially to cardiolipin (CL). SLE-prone (NZW×BXSB) F1 and (NZB×BZSB) F1 mice showed severe thrombocytopenia in association with the appearance of both platelet binding and anti CL autoantibodies. We studied the relationship between thrombocytopenia and the production of platelet binding antibodies and anti-CL antibodies in these mice. We found that (1) (NZB×BXSB) F1 mice developed more severe thrombocytopenia associated with a higher of platelet-binding antibodies than did (NZW× BXSB) F1 mice, however, there was no difference in the titer of and-CL antibodies between two F1 mice. (2) Thrombocytopenia correlated well with the titer of platelet binding, but not anti CL, antibodies in [NZW× (NZW×BXSB) F1] backcross mice. (3) Normal BALB/c mice injected with hybridoma cells producing monoclonal anti platelet, but not anti-CL, antibodies showed thrombocytopenia. These findings suggest that thrombocytopenia observed in these mice was mainly due to the production of anti-platelet autoantibodies.
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  • Iuvestigation of heparin-released platelet factor 4 (HR-PF4) in male non-insulin-dependent diabetic patients
    KENTARO MOCHIZUKI
    1993 Volume 39 Issue 2 Pages 235-240
    Published: June 20, 1993
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.39.235
    JOURNAL FREE ACCESS
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    Platelet factor 4 (PF4) on the surface of endothelial cells binds to intravenously administered heparin and is released into the bloodstream as heparin-released PF4 (HR-PF4). However, the clinical significance of HR-PF4 is uncertain. In this study, the relationship between the diabetic state, particularly microangiopathy, and HR-PF4 was investigated. Sixty U/kg of heparin was injected into 124 male non-insulin-dependent diabetic patients and 9 healthy male volunteers. Blood samples were taken before and 15 minutes after heparin injection. The blood samples were mixed with EDTA and theophyllin. The samples were centrifuged at 3000 rpm at 4°C. The supernatant liquid was stored at -20°C until PF4 measurements were performed. The HR-PF4 levels did not differ significantly between the diabetic group and the control group. HR-PF4 levels were correlated with age and disease duration (r=0.265, p<0.05 and r=0.243, p<0.005, respectively). Diabetic patients with microangiopathy had significantly higher HR-PF4 levels than patients without microangiopathy (p<0.05) (patients' age and disease duration were matched.). These results suggest that HR-PF4 reflects the progress of diabetic retinopathy and nephropathy, i. e. microangiopathy in vivo.
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