Through three years since 1952 till 1954. the Ministry of Labor made investigation, into silicosis among twenty thousand workers. The author had an opportunity to examine about 7300 cases out of the twenty thousans and make inquiries into the prevalence of pneumoconiosis in consideration of age, the years of employment in the dusty works and of the age of getting the work. Together with these, the author made formal investigation into pulmonary mottling. 1. The prevalence rate of pneumoconiosis when considering the age, is much higher among those even if they are young who are working in exposure to heavy dust than among those working in light dust and among the former had very severe cases of pneumoconiosis been found. 2. When considering the years of employment in the dusty works, the occurence of pneumoconiosis is since very early and sufferers are many among the workers in exposure to heavy dust. 3. When considering the age of beginning the work, there are much more cases among early beginners and even if their years of employment in the works are the same, the former suffer badly. 4. Inquiries into coal mining in several districts made it clear that the prevalence rate of pneumoconiosis in Chugoku District and the western part of Kyushu District are almost the same and severe cases or sufferers among the employees of short years are many in Tohoku District. 5. Pulmonary mottling of those employed in different works are fairly distinct : of workers in exposure to heavy dust we find various kinds of pulmonary mottling but of those in exposure to light dust, linear shadow and broken shadow are ascertained many and other kinds of shadow are found few. 6. As for the influence of pulmonary mottling from the viewpoint of X ray morphology, linear, reticulate or broken shadow than other shadows if the cases have pulmonary emphysema or adhesion of pleurisy.

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Six cases showing 14 and 6 per second positive spikes of “thalamic and hypothalamic epilepsy” named by Gibbs, F.A. and Gibbs, E.L. were reported. These were two cases of autonomic epilepsies, one “Tic”, one showing symptoms of abdominal epilepsy and child-shizophrenia, one narcolepsy and one case with obsessive compulsive symptoms who had received electric shock treatment ten times. The age of patients ranged from 10 to 17 years and in all cases 14 and 6 per second positive spikes appeared in sleep recordings. The site of occurence was on both hemispheres with bilateral synchrony in two cases (the case with obsessive compulsive symptoms and that of child-shizophrenia), and unilateral on the right hemisphere in others. Two cases of autonomic seizures were improved markedly by administration of diphenylhydantoin, tridione etc., but only partial alleviation was obtainded in narcolepsy and in the case showing obsessive compulsive symptoms. The anticonvulsant drugs were ineffective in “Tic” and child-shizophrenia.

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Corelation between cystoscopic examination and urine cultures and their relation to clinical symptoms were observed in 490 cases of patients with diseases of the urinary bladder seen at Urology department of Juntendo University Hospital in the last 5 years. 1. Incidence of bladder diseases was significantly higher in females with the ratio of 2.24 : 1 when compared with male patients. This fact is beliebed to be due to anatomic and physiologic differences in sexes. However in patients under 10 years of age, a higher rate was seen in males. 2. Seasons : There was little change in male cases outside of January but in female cases the months of June, July and August was especially high and showed a rate of 34.6 percent. 3. Age : The highest rate was seen between twenty to thirty years of age in females. 4. Bacteria : Coli group was highest followed by staphylococci. 5. No specific mucus membrane changes were seen in bladders infected by the coli group. 6. Cystitis from staphylococcus albus showed distnict characteristic membrane changes. The infection was generalized and the membrane showed distinctive hemorrhagic spots and reddening due to capillary dilatation and engorgement. 7. Fungus infections did not show specific membrane changes. Relatively higher age group (av. 39.75) was infected and was rarely seen in summer months but mostly between october and march. 8. Cystitis of the trigone was most frequency encountered and in 940 cases, 134 cases were seen. It was mostly seen in female cases with 115 cases seen compared to 18 male cases (1 : 6.4).Those in the marriaging age group and of sexually mature group of 20 age group and 30 age group showed highest incidence. Of 134 cases, 84 cases (62.69 percent) were seen. This is an indication that in women retrograde infection is most frequent. In trigonitis the subjective symptoms are more pronounced in relation to the light membrane changes seen. This shows the sensitivity of trigone and its influence on the internal sphincter.The bladder volume of inflamation in the trigone show relatively little change with the average being 304cc, this is believed to be due to the relative immobile characteristics of the trigone. 9. In hemorrhagic cystitis ecchymosis and petechia are seen. In staphylococcus albus infection petehia is most frequently present and in coli group infection ecchymosis is most common.Hematuria is present in most cases and of the total number of 123 cases, 63 cases of gross and 50 cases of microscopic hematuria was seen. Only 10 cases did not show any hematuria. The petechia was frequently microscopic and ecchymosis presented gross hematuria. The site of bleeding was found to be mostly in the lateral walls followed by anterior wall and then the trigone. The common site of lateral wall for bleeding is believed to be due the extensive and erratic movement of this region. 10. Leukoplakia was thought of as occurring mostly in males of over middle age and as a relatively rare disease state. Howerver Taguchi in 1941 indicated that this disease was not rare and was often seen in sexually mature age-group females. This difference in view point lies in fact whether Putschar's präleukoplakie is included in the leukoplakia or whether it is to be excluded. Clinically it is difficult to differentiate between the two forms. When careful cystoscopic examinations are made, with the so-called preleukoplakia included there are unexpectedly frequent cases of leukoplakia. In our own experiences female cases were significantly higher and the age group was between 20 and 30. The site mostly seen with these changes were the trigone the neck of the bladder. The duration necessary for the development of leukoplakia is contary to expectation short and can develop by 3 weeks. We have experienced two these cases and these cases agree with the animal experiments of Tsuji et al.

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The present paper deals with a part of the series of the author's studies on experimental arsenious poisoning. Expriments were made by giving 1% arsenious acid solution into the stomach of mice, inbred strain ddY. After mice were killed by ether, their specimens were stained by Hematoxylin and partly Sudan III. For histochemical studies, Schümacher's method was used. The following results were obtained. (1) Histological changes by arsenious acid were most severely in the kidneys and nextly in the liver. Marked atrophy was seen in the spleen. (2) Arsenic granules were detected more frequently in the liver and the spleen than in other organs. (3) Presence of the arsenic granules were not seemed to have any relation to disturbance of the organ.

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Present paper deals with 72 strains of E. coli isolated from urin of the urinary infected patients. Biochemical and serological characteristics and hemolytic activity of the strains were studied. Results obtained were follows : (1) 60 strains (83% of the isolated strains) were included in the known serological typing O1-to O134. O2, O3 and O25 types were dominately found, that is 4, 6 and 8 strains. (2) 4 strains, identiffed to O75 type, were seemed to be causative organism of not only infantile gastroenteritis but urinary infections. (3) K-antigen and hemolytic activity were observed in 15 strains (21%), but 1 strain, having K-antigen, did not show the hemolytic activity. (4) On the biochemical study, all strains were identified to E.coli.

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Glycolysis-power of erythrocytes in hemolytic disease have been investigated. Differences of glucose-, lactic acid-, and pyruvic acid concentration in blood of healthy man, of anemia with poor hemoglobin, of accquired hemolytic anemia, or of experimental hemolytic anemia before and after shaking for 60 min. at 37°C in aerobic and anaerobic condition adding heparin were compared and their relations to the lives of erythrocytes in each blood were also investigated. In accquired hemolytic anemia, the power of glycolysis obviously increases as compared with that of healthy man or anemia of poor hemoglobin, and the lower the power of glycolysis transfused into healthy man is, the shorter the life of erythrocyte is. In experimental hemolytic anemia, the power increases greatly and the life of erythrocyte is normal for 3-6 hrs. after the injection of antisera to blood cells, but after 12hrs. the power decreases to a extent lower than normal state and the life of erythrocyte is also shortend. Those relations between the powers of glycolysis and the lives of erythrocytes in clinical and experimental hemolytic anemia imply the accelerated declining of erythrocytes in such a disadvantageous condition that they are accompanied with antibodies.

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