Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 41, Issue 1
Displaying 1-21 of 21 articles from this issue
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Contents
  • An epidemiological study of outpatients at the mental hospital of Juntendo University School of Medicine-Part I
    MASATAKA HIROSAWA, EIJI SAITO, MINORU ARAI, MASATSUGU SHIMAZAKI, JUNKO ...
    1995 Volume 41 Issue 1 Pages 84-94
    Published: June 27, 1995
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.41.84
    JOURNAL FREE ACCESS
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    A survey of outpatients at Juntendo Koshigaya Hospital was carried out. Statistical analysis was performed to clarify the clinical characteristics of a mental hospital associated with a university school of medicine which is a very unique facility in Japan. In this study, we paid special attention to the characteristics of the group surveyed. Two groups were chosen for comparison. The first included new patients, who ertered to the psychiatric treatment programme between April 1989 and March 1991, the second was selected all outpatients, who were under care at the point of survery (March 31, 1991). The results obtained from these two groups were analyzed separately and compared. At our hospital, the number of female patients was significantly higher than that of men (P<0.001), and age of female patients was significantly higher than that of men (P<0.001). In comparison to the data obtained from studies at other facilities, we considered these features reflected the epidemiological features of the suburbs of a metropolitan, rather than that of mental hospital associated with a university school of medicine. However, the composition of diseases, occupation of patients, and the methods of consultation, demonstrated the clinical characteristics of our hospital which are similar to that of psychiatric treatment departments in university hospitals, and different from that of mental hospitals in Japan.
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  • Radiological investigation of the superior thalamic vein
    趙 成済
    1995 Volume 41 Issue 1 Pages 95-101
    Published: June 27, 1995
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.41.95
    JOURNAL FREE ACCESS
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    The superior thalamic vein (STV) arises from the center of the thalamus due to the convergence of small veins. STV runs medially in the dorsomedial nucleus of thalamus and turns posteriorly at the wall of the third ventricle, then drains the internal cerebral vein (IVC). This STV is easily identified on lateral films during vertebral angiography. When STV runs medially in the thalamus, STV is projected as a dot under IVC on the venous phase of vertebral angiography. In this study, the dot of STV was labeled the D-point. And the segment of the STV from the D-point to the IVC was labeled the P-line. The D-point was measured using the IVC measurement described by Potts (1963). Measurements were obtained on vertebral angiography in 55 normal cases. Absence of bilateral STV was noted in only 3 cases. The D-point was visible in 95% (52/55) and appeared to be located at a regular distance from the venous angle. Variations in the P-line were classified 3 patterns ; type A (17%) draining IVC immediately from the D-point, type B (33%) running parallel to the IVC and draining the posterior part of IVC and type C (50%) draining into the vein of Galen. The D-point was located in the small area under the IVC and the visualization rate of the D-point was high. So this point is useful in estimating the dorsomedial nucleus of the thalamus. Observation of the P-line is useful in determining information regarding the posterior portion of third ventricle on vertebral angiography.
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  • Immunohistochemical studies on the distribution of apoptotic cells and the developmental pathway of B cells in human tonsils
    MASATO FUJIMORI, KAZUO TERASHIMA, SACHIKO HIROSE, GINICHIRO ICHIKAWA
    1995 Volume 41 Issue 1 Pages 102-114
    Published: June 27, 1995
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.41.102
    JOURNAL FREE ACCESS
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    Apoptosis is a distinct type of cell death that differs fundamentally from degenerative death or necrosis and timed induction of apoptosis appears to play an important role in normal cell turnover and development. Accumulating evidence suggests that apoptosis is a critical event in the negative selection process that functions to prevent autoimmunity in the thymus and bone marrow. Recently, apoptosis has also been suggested to plays an important role in the selection of B cells which produce high affinity antibodies with immunoglobulin variable region gene mutations in the germinal center. In the present studies, we examined the distribution of apoptotic B cells in human tonsils using the TdTmediated nick end labeling method. Apoptotic cells were abundantly observed in both the dark, and the basal light zones, and less in the apical light zone in the germinal centers. Apoptotic cells were also scarce in the mantle zone located over the germinal centers and in areas outside the lymph follicles, such as lymphoepithelial and interfollicular areas. Most of the B cells in the dark, but not light, zone expressed a proliferating cell antigen, Ki-67. Together with the finding by others that affinity maturation of B cell in association with the immunoglobulin variable region gene mutations begins to occur in the dark zone, the apoptosis in the dark zone appears to occur in two mechanisms, one as a response to overproliferation of B cells and one as a negative selection of low-affinity or non-functional B cells that generate through the affinity maturation process of B cells. The basal light zone lacked Ki-67+ cells and seemed to be the main site of affinity maturation. Thus, the apoptotic cells in this region are probably under the selection process. The apical light zone contained many activated T cells and B cells expressing differentiation/activation antigens, CD23 and CD86, suggesting that this area is the site of B cell differentiation to memory B cells or preplasma cells which subsequently migrate outside the germinal centers. Thus it is reasonable that there are few apoptotic cells in this region.
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  • Thirty-year autopsy statistics of myocardial diseases in Japan
    YASUKO KAWANO
    1995 Volume 41 Issue 1 Pages 115-123
    Published: June 27, 1995
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.41.115
    JOURNAL FREE ACCESS
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    The epidemiologic data on myocardial disease is relatively insufficient because of its rarity. The author tried to clarify its epidemiologic characteristics in autopsy cases during the 30 years of 1958-1987, using the Annuals of Pathological Autopsy Cases in Japan published annually by the Japanese Society of Pathology and to utilize the date for elucidation of pathogenesis of cardiomyopathy. I picked up cases with cardiomyopathies, including dilated (DCM), hypertrophic (HCM), restrictive or endomyocardial disease (EMD (R)) and unclassified (UCM) types, primary endocardial fibroelastosis (EFE), and myocarditis diagnosed as viral, idiopathic or nonspecific and made statistical analysis. The same analysis was made using selected cases under 15 years of age. There were 1,562 cases with DCM (0.21%), 458 with HCM (0.06%), 241 with EMD (R) (0.03%) and 714 with UCM (0.06%), 1207 with myocarditis (0.16%). The incidence of DCM, HCM and myocarditis began to increase from the latter half of the 1970's. The preponderance of males for DCM and that of females for myocarditis was found. Age distribution pattern of DCM and HCM showed two peaks in the young and middleaged groups in early years, but in recent years, the peaks shifted to 50-60's and to 60-70's, respectively. The complication of malignant neoplasms or nephrosclerosis in cases with HCM was more common than with DCM. The incidence of DCM was about three times higher in the adults than in the children, whereas those of HCM and myocarditis was almost equal in both groups. The annual change of incidence of cardiomyopathy and myocarditis in the children was closely related with each other. The fluctuation pattern of EFE was similar to that of myocarditis of all ages. These findings suggest that myocarditis is associated with cardiomyopathy in part and EFE as the pathogenesis or at least the cause of death.
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