Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 41, Issue 3
Displaying 1-21 of 21 articles from this issue
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Contents
  • The histopathological features of chronic hepatitis C in children
    -In comparison with those of chronic hepatitis B-
    AYANO INUI
    1995 Volume 41 Issue 3 Pages 338-348
    Published: November 15, 1995
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.41.338
    JOURNAL FREE ACCESS
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    The histopathological features of chronic hepatitis C in adults include lymphoid follicles and/or aggregates in the portal tracts, bile duct damage, fat droplet in the hepatocytes and Mallory body-like materials. To determine the histopathological features of chronic hepatitis C in children, we examined 39 biopsy specimens from 34 children with chronic hepatitis C and 18 biopsy specimens from 16 children with chronic hepatitis B. Each biopsy specimen was graded on 8 different histopathological points. At the time of biopsy, the average age of children with chronic hepatitis C was 9.5 yr vs. 11.6 yr for chronic hepatitis B. No specific features were observed in children with chronic hepatitis C. Features more commonly observed in children with chronic hepatitis B were piecemeal necrosis (100% vs. 74%, P=0.018) and bridging necrosis (33% vs. 8%, P=0.038). In chronic hepatitis C, features more commonly observed in children with hepatitis C accompanied by hematological disorders or malignancies than in those with non-malignancies were bile duct damage (63% vs. 42%), lymphoid follicles and/or aggregates in portal tracts (59% vs. 42%), fat droplets in hepatocytes (30% vs. 17%) and Mallory body-like materials (19% vs. 8%). We conclude that liver histology in children with chronic hepatitis C does not show specific findings which can differentiate chronic hepatitis C from chronic hepatitis B, which histologically is a more aggressive disease.
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  • Indication criteria of factor XIII concentrate for patients with Schönlein-Henoch purpura
    MASAHIRO SAITO, KAORU OBINATA
    1995 Volume 41 Issue 3 Pages 349-354
    Published: November 15, 1995
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.41.349
    JOURNAL FREE ACCESS
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    In order to determine the indications for administering human blood-coagulation factor XIII fraction (factor XIII concentrate) to patients with Schönlein-Henoch purpura, the clinical effect of factor XIII concentrate therapy (F therapy) was compared with that of steroid therapy (S therapy). Clinical symptoms were impoved immediately in eight of 10 patients receiving F therapy. The levels of factor XIII increased to the normal range or above in all patients in the F therapy group. All 10 cases in the S therapy group showed improvement after 3 days of administration. However, two patients had prolonged symptoms and 4 patients relapsed. As for the abdominal symptoms, 6 patients in the F therapy group improved, but 2 patients needed further steroid administration. Two patients coutinued to have tarry stool and one had relapse of abdominal pain in S therapy group. The duration of hospitalization and the complication rate with purpura nephritis were not different between the two therapy groups. It is considered that the F therapy required a shorter term than S therapy and was effective for relief abdominal symptoms in patients with Schonlein-Henoch purpura. In patients with moderate or severe abdominal symptoms and low levels of factor XIII (<90%), factor XIII concentrate therapy may be indicated.
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  • The statistical study of our outpatient clinic for epileptic children for the past 10 years
    HIROSHI TAKAHASHI, TOMOYUKI NAKAZAWA, KYOKO WATANABE, KENICHIRO KANEKO ...
    1995 Volume 41 Issue 3 Pages 355-360
    Published: November 15, 1995
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.41.355
    JOURNAL FREE ACCESS
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    This paper evaluated long-term trend in our outpatient clinic for epileptic children, because the importance in continuous medical treatment for epileptic children has been high lighted in Japan. Ovarall, 430 epileptic children (male 225, female 205) were treated during the past ten years. The types of epilepsy were classified by the International Classification of Epilepsies, Epileptic syndromes and related seizure disordes. Most of the patients initially consulted our clinic during infancy and 30-40 new cases were treated each year. One hundred and eighty-five (43%) epileptic children consulted our clinic directly with complaints of seizures, while 134 cases (31%) were referred by other doctors. One hundred and seventy-six cases (41%) continued to consult our clinic for more than 5 years. Sixty-eight cases (16%) changed doctors. Patients consulting our clinic resided within 10km from our hospital in 82% of the cases. These results may indicate that continuous medical treatment for epileptic children is being successfully given through our facilities.
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  • Identification and functional characterization of mouse integrin β3 subfamily receptor on T lymphocyte and platelet
    HIROYASU ADACHI
    1995 Volume 41 Issue 3 Pages 361-369
    Published: November 15, 1995
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.41.361
    JOURNAL FREE ACCESS
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    The extracellular matrix protein (ECM) receptor, so-called integrin, may play important roles in cellular migration, proliferation and differentiation, and these receptors may also be implicated in T cell migration, adhesion and activation. We previously reported that integrin-like molecules might be involved in the lymphokine-activated killer (LAK) cell cytolytic activity against some target cells by using a monoclonal antibody (mAb), RMV-7. Immunoprecipitation and western blotting studies revealed that the antigen recognized by RMV-7 was identical with mouse vitronectin receptor (VNR; αvβ3), but RMV-7 could not bind to αv negative mouse platelets, indicating that RMV-7 recognizes the αv subunit of integrins. In this study, I generated an mAb against the mouse integrin β3 subunit (CD61) to examine the biological functions of the integrin β3 subfamily in the mouse system. After immunization with affinity purified VNR, a hamster mAb, HMβ3, was established by screening mAbs that reacted with T cell hybridoma (αv positive) and platelet (αv negative). HMβ3 reacted with not only T cell hybridomas and platelets but also activated T cells and megakaryocytes. Moreover, adhesion of activated T cells to fibronectin, vitronectin and fibrinogen was strongly inhibited by HMβ3. I conclude that HMβ3 will be useful for studying the physiological role of β3 integrins in vivo.
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