Juntendo Medical Journal

Recently, the increase of STD propounds a big problem. Particularly, it should be noticed that non-symptom-infection is widely spreading among young generation. This report mentions that the current condition, its characteristics, countermeasure, and the treatment of STD including HIV. At the same time, it explains about the new law of infectious diseases.

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Objective : The effects of regular exercise training on the expression of heat shock protein (HSP) in skeletal muscle of senescent animals are unknown. Therefore, the purpose of this study was to investigate the effects of long-term exercise on skeletal muscle HSP expression in both young and old rats. Materials and Methods : Young adult (12 weeks old) and old (100 weeks old) female Fisher 344 rats were assigned to either a sedentary control or an endurance exercise training group (n= 6/group). Rats in both training groups completed a treadmill exercise program (75-80 % Vo2max, 60 min/day, 5 days /wk) for 10 weeks. After 72 hours of completing the training program, the soleus (SOL) and extensor digitorum longus (EDL) muscles were excised and the levels of HSP72 were determined by Western blot. Results : No differences (p>0.05) existed in the basal levels of skeletal muscle HSP72 between young and old sedentary control animals. Compared to age-matched sedentary controls, exercise training resulted in increased (p<0.05) levels of HSP72 in skeletal muscles in both young (SOL+22%, EDL+200%) and old animals (SOL+15%, EDL+115%). Conclusions : Endurance training increases the expression of HSP72 in skeletal muscle in young and old animals. However, the response to endurance training in fast skeletal muscle (EDL) becomes moderate with age.

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Purpose : The purpose of this study was to evaluate the effect of the ductal structure on the neogenesis of pancreatic endocrine tumors, compared with the pancreatic ducts in normal pancreases. Objects : This study consisted of 30 endocrine tumors of the pancreas and 50 normal pancreatic tissues from autopsies. Methods : Tissue blocks were made from the head, body, and tail portion of the autopsy pancreases and the endocrine tumor of the pancreases. The diameter of the pancreatic ducts and the thickness of the elastic fiber around the ducts were measured and the relationship between them was examined. The continuity between the endocrine cells and the pancreatic ducts in normal pancreases, and the continuity between the tumor cells and the ductal structures were examined. Immunohistochemical studies were performed using antisera against CA19-9, lipase, NSE, carbonic anhydrase- II. Ductal structures were found in 9 of 30 endocrine tumors. The positivity rate of the expression of CA19-9, CA- TI, and lipase were 100%, 100%, 77.8% in the ductal structures of the pancreas. In 7 of the 9 cases, the ducts were connected to the tumor cells and except for 1 case, they were not surrounded by elastic fibers. In 2 of the 9 cases, the ducts were not connected to the tumor cells and were surrounded by elastic fibers. The elastic fibers were not present in the 50.8% of the pancreatic ducts, which had a diameter less than 80μm. There is a correlation between the diameter of the pancreatic ducts and the thickness of the elastic fibers in normal pancreases. Continuity between the ducts and the endocrine cells was found in 8 of 50 cases (16%). Conclusion : It is considered that the ducts surrounded by elastic fibers were preexisting ducts and the ducts that had no elastic fibers around them and were connected to the tumor cells were newborn ducts. We speculate that the newborn ducts were differentiated from the tumor cells.

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