Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
Volume 6, Issue 6
Displaying 1-17 of 17 articles from this issue
  • Akira OGONUKI
    1960 Volume 6 Issue 6 Pages 375-382
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
    The O2-consumption by the human tubercle bacilli in the emulsion of organs from non-treated guinea-pigs which are considered more sensitive to the orgrnisms was measured. The respiration of the tubercle bacilli was most accelerated in the emulsion of brain and lung. These facts suggest that some respiratory stimulating components are present in these organs, and a few discussions were added to the results.
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  • Chikakazu OKAMURA
    1960 Volume 6 Issue 6 Pages 383-402
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
    The morphology of oral spirochetes in monkey was studied by the author fluorescent-microscopically, and the following results were obtained. 1. Spirochetes were recongnized in every mouth of 132 examined monkeys. 2. Macro Borrelia type spirochetes had extra large spiral and Micro-Borrelia type spirochetes had comparatively large spiral, however, the number of spirals were scarce. The length and width of spirochetes were intermediate. 3. Treponema type spirochetes possessed intermediate width, and had short and small spiral, however, the number of spirals were scarce. 4. Leptospira type spirochetes were thin, long and had smooth spiral. The number of spirals were numerous. 5. Micro-Borrelia type spirochetes were shortest and thinest, comparad with oral spirochetes in human and canine, and each spiral was also smallest among them. 6. Treponema type spirochetes were thin, short and intermediate type between human and canine oral spirochetes, and each spiral was smallest among them. 7. Leptospira type spirochetes showed thicker and shorter body and smaller spiral than human and canine oral spirochetes, but longer and thicker body than Leptospira icterohaemorrhagiae. 8. The morphology and movement of monkey's oral spirochetes were influenced by various drugs including antibiotics and arsenic compounds.
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  • Terumi Hino
    1960 Volume 6 Issue 6 Pages 403-410
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
    In following hematopoetic disturbances after radiation most studies are centerd around the leucocytes and blood platetes system. Reports on the effect on erythrocytes system are few. However, the seemingly relatively unresponsive effect of radiation on erythrocytes can be attributed to the enormous number of peripheral red cells and its long lifespan of 120 days. In the bone marrow the young erythroblasts are more suseptable to the effects of radiation then either the leucocytic or blood platetes system. In order to observe these effects directly, intravenous globulin isotope 59Fe test was found to be a good indieator of the radiation injury of the hematopoetic system. It is believed to be a reliable indicator of chronic and acute hematopoetic disturbances due to radiation.
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  • II. Antigenic Analysis of four Species of the Genus Kloeckera
    Jiro KATSUYA
    1960 Volume 6 Issue 6 Pages 411-419
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
    The authenic strains of the four species of the genus Kloeckera weree used for antigen analyses by means of slide agglutination method with monospecific or absorbed antisera homologous to antigens of the genus Candida, because there are seroglogical cross reactions among many species of the genera. Then, antiserum of a species was absorbed repeatedly with heated cells of several species of the genus Candida in order to find a new antigen, until the absorded antiserum was exhausted. The new thermostable antigen 40 was found in Kl. africana, Kl. corticis and Kl. antillarum. Antigenic strutures of the species were confirmed by the reciprocal absorption and the comparative study was carried out with a few strains of the same species. Antigenic structures of the four species were shown as follows : Kl. apiculata has thermostable antigens 1, 9, 10, 26, 27, 28, 32 and new thermolabile antigen l, Kl. africana has thermostable antigens 1, 2, 3, 4, 6, 9, 32, 40 and no thermolabile antigen, and it is completely the same to the antigenic structure of Kl. corticis. Kl. antillarum has thermostable antigens 1, 2, 3, 4, 6, 9, 40 and no thermolabile antigen.
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  • Jiro KATSUYA, Heiji MARUYAMA, Yoshimi WATANABE, Satoru EDA, Kenichi OO ...
    1960 Volume 6 Issue 6 Pages 420-429
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
    Strains of pathogenic staphylococci isolated from outpatient at the S. D. F. central Hospital duriug 2 years between October 1, 1957 and June 30, 1959 tested for susceptibility to 7 antibiotics and subjected to phage typing. A tube-dilution technipue with determinations of bacteriostaiic ane bactericidal endpoints was employed. The following conclusions have been reached : 1) Out of the 537 strains isolated from skin lesions. 494 strains (92.5%) were gram-positive cocci and 219 strains (41%) were pathogenic staphylococci. 2) Marked differences were found between the coagulase-positive staphylococci and coagulasenegative staphylococci in the production of pigment, fibrinolysin and mannit fermention. And these characteristics are said to correlate well with coagulase production as an index of pathogenicity. 3) Among the 219 strains of pathogenic staphylococci, penicillin resistat strains occupied 86%, and these strains were resistant over 60% to terramycin and aureomycin. Although erythromycin and chloramphenicol were potent bactericidal agents. 4) The general incidence of antibiotics-resistant staphylococci appeared to be related to the frepuency and intensity of use of those antibiotics. 5) Of the strains isolated from skin infections 28.5% were typable, and the strains lysed by phages of Group I were most frequent among isolated strains. The phage pattern identified as 80 was the only frepuent one obserbed in this study, and showed increased. resistance to antibiotics. 6) In general, tube-dilution tests were in good agreement with the choice of an antibiotic for the therapy of a staphylococcal infection. The references and the correlation between agar plate and tube dilution sensitivity tests were described.
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  • Report 1. Application to Various Types of Experimental Anemias
    Riman KOIKE
    1960 Volume 6 Issue 6 Pages 430-432
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
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  • Report 2. Appluation to Evaluation of Cysteine Effect on Irradiation Injury
    Rimon KOIKE
    1960 Volume 6 Issue 6 Pages 433-434
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
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  • Report 3. Application to Evaluation of Intravenous Bone Marrow Therapy
    Rimon KOIKE
    1960 Volume 6 Issue 6 Pages 435-440
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
    Experimental intravenous Fe59 globulin has been used quite widely and is now being applied to clinical hematological cases. In our experiments with rabbits and dogs we have found this metbod to be a more accurate reflection of the haemopoetic function when compared to other methods used. (Report 1) With experimental anemias prolongation of plasma clearance and lowering of utilization rate was seen. (Report 2) Intravenous cysteine was found to promote early return to normal values of plasma clearance and utilization rates and prevention of irradiation injury was very evident showing relatively good results even with immediate administeration of cysteine after irradiation. (Report 3) When intravenous Fe59 was applied to intravenous bone marrow therapy in rabbits plasma clearance and utilization rate was near nornal showing the effectiveness of this method. In dogs the recovery time to T/2 values of plasma clearance was increased and the white blood cell count was relatively well stabilized.
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  • Ichiro TANAKA
    1960 Volume 6 Issue 6 Pages 441-452
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
    1. The method of the tryptophane-perchloric acid reaction by Seibert and his associates was used to determine serum sialic acid levels in various discases. The author obtained results similar to other methobs. 2. The parallel increase of sialic acid, protein-bound-polysaccharide and mucoprotein was observed in cases of collergen disease, malignant neoplasm, metastatic neoplasm of liver, uraemia and bacterial or nonbacterial infection. And so ratio of protein-bound-polysaccharide and mucoprotein was high especially in case of liver cirrhosss. 3. Increase of protein-bound-polysaccharidle and decrease of sialic acid and mucoprotein were obse rved in cases of parenchynratous liver disease. 4. Though serum sialic acid and mucoprotein decrease in lipoid nephrosis, decrease of protein-bound-polysaccharide was not found. 5. Allmost all of the serum positive for C-reactive protein had high sialic acid levels. 6. The authors experiments suggest thah sialic acid is related more likely to protein-bound-polys-accharide than to mucoprotein. 7. Clinically and experimentally, changes of those serum glycoprotein levels in collergen diseases and in malignant neoplasm by many drugs, especially by abrenocorticosteroids and “anti-neoplasmsub-stances” were studied. Levels of serum glycoprotein became generally lower according to their rate of recovery from their condition.
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  • II. Antigenic Analyses of Four Species of the Genera Hansenula and Pichia
    Yoshimi WATANABE
    1960 Volume 6 Issue 6 Pages 453-459
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
    Amemiya, Nishikawa and Fukazawa reported respectively that there are serological cross reactions among many species of the genera Candida, Hansenula and pichia. Four species of the genera Hansenula and Pichia, of which strains had not been established the antigenic strutures, were obtained for antigen analysis. The experiments were carried out througth the slide agglutination method using monospecific or absorbed antisera homologous to the antigens of the genus Candida. Then, an antiserum of a species was absorbed repeatedly with heated cells of several species in order to find a new antigen, until the absorbed antiserum was exhausted. Antigenic structures of the species were confirmed by the reciprocal absorptions. Hewever no new thermostable and thermoladile antigen was found. Antigenic structures of the species as follows : H. suaveolens has the thermostable antigens, 1, 2, 14, 15, 16, 17 and 20. H. holstii has antigens, 1, 2, 3, 13, 14, and 15. H. matritensis has the antigens 1, 2, 3, 4, 9 and 14, and the antigenic structure is the same to that of Torulopsis globosa. P. fermentans has the aatigens, 1, 2, 5 and 11. All he species have not any thermolabile antigen.
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  • (1st Report) Clinical Symptoms and the Pathomorphological Findings of Diabetic Patients.
    Naoe NAKAMURA
    1960 Volume 6 Issue 6 Pages 460-481
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
    Twenty cases of diabetic deaths were studied during 1951 to 1958 in the medical department of The First National Hospital of Tokyo. 1) The intercapillary glomerulosclerosis in the meaning of Kimmelstiel-Wilson were observed in 12 of our 20 cases. Grading of the lesions after Laipply as follows : one _??_ case, four _??_ cases, five _??_ cases and two + cases. 2) This nephropathy appeared clinically in the 3rd decade and more frequent in the 5 to 6 th decades. Males and females were affected equally. The diabetic nephropathy tends to appear in the long-term diabetics and is complicated by edema, increase in N.-P.N., and vascular lesions. Eight of anatomical proved Kimmel-stiel-Wilson casas were notically diabetic nephropathy. Juvenile diabetics and hypertensive cases showed higher percent-ages of retinitis. N.P.N. increase over one month duration showed poor prognosis. All of the nephrotic cases expired 3 to 4 years after the onset of albu minuria. In cases of improved albuminuria, however, infection, vascular lesions of heart or brain may cause death. Uremic deaths were observed in 8 cases. 8 of 20 cases not showed intercapillary glomernloscrelosis, of which 4cases were pancreatic carcinoma, only one of remaining 4 cases showed vascular lesion.
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  • (2nd Report) Observation of Urine and Clinical Symptoms of Diabetic Patients.
    Naoe NAKAMURA
    1960 Volume 6 Issue 6 Pages 482-496
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
    640 diabetic cases were observed clinically during 7 years bstween 1951 to 1958, including 21.2% of positive urine analysis. 1) Most positives of analysis revealed patterns of chronic nephritis, and only 11 cases showed more than 6% albuminuria. 2) Cases of positive urine analysis increased in fifth and sixth decades. Males and females were equally affected. 3) Long-term diabetics showed positive urine analysis higher than others in persentages. 4) In the positive urine analysis groups more hypertension and retinitis were noticed. In accordance with diabetic stages there appeared anemia, increase in N.P.N., and change of ST. T. in ECG. Two cases of myocardial infarction were observed. 5) Water test revealed delayed diuresis. P.S.P. and F.F. value lowered in 2/3 cases. TmG value also lowered. Higher renal threshold was Proved. 6) In fatal cases death followed under the condition of uremia, apoplexia cerebri and heart failure.
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  • Ariko MACHIDA
    1960 Volume 6 Issue 6 Pages 497-510
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
    In 1954 and 1959 measurements of_the body obtained from children (4-17 yrs. of age) who were cared for more than one year in 10 foundling-homes in Tokyo. The menstrual rate of girls in the institutions was examined with the following results : 1. Even the' they line in Tokyo, children in foundling-homes are smaller in height and are of a short and stout type in many cases. (The nutritive conditions are moderate among the overhelmingly great majority of the children.) 2. In children of foundling-homes, the length of the pectral limd and pelvic limb is small, but there is no clear-cut difference in the length of the head, the wifte of the head, the wodth of the shoulder, the width of the chest, the thickness of the chest, the height of the vertex while sitting, the width of the pelvis and the circnmference of the arm, between the children of such homes on children of ave-rage, normal homes. 3. Thl menstrual rate of girls it the institutions is low. Particularly girls of 14 or over, who live near farm villages, show a low menstrual rate. 4. These characteristic findings of children of the foundling-homes are more marked in public insti tutions than in private foundling-homes, but this can not be confirmed since the numder of foundlinghomes is small. 5. By comparing 1954 with the year 1959, it is fonnd, that doth children in foundling-homes and average normal homes have improved in growtoh, (the body and first menstruation) and that particularly children in foundling-homes, have improved in physique so that they are gradually approaching hte physique of children in the average, normal home.
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  • Tatuo OCHIAI
    1960 Volume 6 Issue 6 Pages 511-542
    Published: December 10, 1960
    Released on J-STAGE: November 22, 2014
    JOURNAL FREE ACCESS
    The auther studied clinically and morphologically 26 morbid cases of diabetics during 1952-1958 in the medical department of The First National Hospital of Tokyo. Including 16 cases of Kimmelstiel-Wilson Syndrome, this study was especially concerned for clinical and morphological corelations about the vascular walls and the arteriolar changes in various organs. 1). The main cause of death were in 54% the brain, heart and renal failure with marked arteriosclerosis. 2). Arteriosclerotic changes of the diabetic cases were higher than the controle groups. Arteriosclerotic changes diminished in following order ; A. hypo gastrica, Aorta, A. ilica comm., Aa. coronaria, A. coeliaca, A. mes. sup.. 3). Mean age of morbid cases was 56.9 years. Arteriosclerosis was suspected to begin earlier and become heavier in the diadetics than non-diabetics. Males tend to affected heavier than females. 4). Long-term diabetics, positics of albuminuria, hypertensives and patients having some vascular disorders showed higher grade of arteriosclerosis. patients over 50 years tend to show thes condition, but not missing in youngers. 5). 16 of 26 cases showed intercapillary glomerulosclerosis, and 63.0% of which showed hypertension. Higher grade of sclerosis were found in tho long-term diabetics. Hypertensives. 6). Proximal aorta showed only slight sclerotic number of 0.98, meaning fatty and atheromatic small foci, distal aorta showed markedly atheromatous, calcified and ulcerative foci, this number was 3.24. The sclerosis of coronary arteries were most prominent in Ramus desc. ant., and lesser in Ramus des. Post. dex., and in Ramus circumflex. Thes sclerosis wers mostly atheromatic and sometimes calcified. Hypogastric and common iliac arteries were calcified or ulcerative. Renal arteries were atheromatous. Heart failures of long-term diabetics must be noticed clinico-patholo-gically. 7). Hyaline deposits of arterioles were noticed in various organs, especially in pancreas, spleen, kidneys and less often in stomach, liver and lungs. This changes were apparentry higher than controll cases. This changes also showed some relationship to diabetic anamnesis, hypertension, ocular symptoms and nephrotic syndrome. 8). There are some relationship between duration of diabetes and these irreversible vascular changes, ths latter may have be responsible for the deathe cause of diabetes. Tte peculiar hyaline deqosits of arteriolar walls and its distribution in visceral organs were studied.
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