順天堂医学
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
7 巻, Supplement1 号
選択された号の論文の16件中1~16を表示しています
目次
原著
  • 富田 義男
    1961 年 7 巻 Supplement1 号 p. 625-647
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    The presence of white patch in the female urinary bladder neck is well-known in the literature, but the nature is not clear. I have recognized white patch in the distal part of the female trigone, near the bladder neck on careful cystoscopic observations. These patches are different appearance from the typical white or gray patches to clouds of epithelium. I examine these patches and some new histologic findings were found. Some experimental study using estrogen or progesterone administration to these patients were performed. In addition the patches alter in the menstral cycles. The details were as followd : 1) The bladder neck of 833 cases were studied by cystoscopic examination and white patsches were found in 276 cases (33.1%). 2) Biopsies of the patsches of 66 cases from 17 to 70 years of age in 276 cases, were performed. The histological natures of these patches were completely different from the transitional cell layers of the urinary bladder. Three types of the patches were noticed histologically. Type I. The basal layers are composed of cylindrical cells, and above these, there are many celles of spinous layers, in which the intercellular bridges are seen. Above these layers the polygonal celles with large nuclei arefound. The superficial celles are flatt and contained nuclei. These layers are parakeratosis but there are not the zone of keratosis. Type II. This type is almost same as type I without the uncertaing the spinous layer in a few cases and the large perinucleare clear cytoplasma with picnotic nuclei were found. In these cells the considerable amounts of glycogen are demonstrated. Several cases have no parakeratosis. Type III. The bassl zone of epithelium consists of ratherthe transitional type cells than the cylindrical, and there are no spinous layers. The superficial cells have polygonal cleare cytoplasma with picnotic nuclei. There are no parakeratosis. This type is interpreted as a hydropic transformation of epithelium by Stoerk. 3) The administrations of estrogen and progesterone change the size, shape and type of the patches. The estrogen are administratied to 11 case. Cystohoricelly estrogen makes the patch bigger and thicker. Histologically estrogen makes more parakeratoric layer and thiner polygonal clear celles with picnotic nuclei and in few cases it alters from type III to II. The progesterone administraction are performed to 9 cases which makes the patch smaller and thinner. Histologically makes the layer less parakeratotic and move polygonal clear celles with picnotic nuclei, and it renders to alter from type II to type III. 4) The periodical changes of the white patches in the menstrual cycles of 9 cases and post-menstrnal changes of 11 cases were studied with following findings. The histological findings are altered in the menstrual cycles and sometimes even the types are also altered in these cycles. The postmenstrual change of the patches are a certain type which are lack of sex hormone and are type I. 5) The inflammation of the urinary bladder neck makes the patch bigger, the patch may be the metaplasia stimulatied of inflammation and estrogen, in the bladder neck mucosa originated from the epithelium of urogenital sinus. 6) These white patches are strictly differentiated from leukoplakia, because these patches in the bladder neck have embryonal predisposition and may be hormone-sensitive squamous metaplasia.
  • 柴沼 裕
    1961 年 7 巻 Supplement1 号 p. 648-651
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    These experiments were studied on the phagocytic action of male rabbits which were castrated and the influence of androgenic hormone in the same condition. 1) In castrated rabbits, the number of leucocytes was not showed a so remarkable tendency but increased slightly, the phagocytic action was decreased to 60% of normal volue after 12 days from their operation and 40 days after recovered to 92%. 2) The number of leucocytes in castrated remarkably increased by androgenic Hormone (Enarmon) 0.4mg every other day in compare with control rabbits and the phagocytic action was showed much the same as normal rabbits. Androgenic hormone would be recoverd almost completly for the decreased phagocytic action of the castrated rabbits. 3) After 1CO days, the number of leucocytes and phagocytic action in castrated rabbits recovered completly, and the both increased about 27-38% by androgenic hormone 0.4 mg every other day in compared with control.
  • 柴沼 裕
    1961 年 7 巻 Supplement1 号 p. 652-660
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    These experiments were studied principally the influence of pituitary-adrenocortical hormone (ACTH, cortisone etc) on the phagocytic action of leucocytes of rabbits which were secondary adrenalectomized before and after. 1) In the directly mixed examination in vitro, the phagocytic action was remarkably decreased by Dexamethason, and was not at least decreased by ACTH and cortisone. 2) In the normal rabbits which, was administrated ACTH and cortisone, the phagocytic action in 24 hours was increased after slightly decrease in the beginning and the number of leucocytes remarkably increased. 3) In the unilateral adrenalectomized rabbits which was administrated both ACTH and cortisone increasing number of leucocytes was decreased and decreasing phagocytic aotion was increased. In the bilaterale adrenalectomized, the number of leucocytes was increased and the phagocytic action did not almost influence. It is suggested by the above observation, the influence of the phagocytosis by pituitaryadrenocortical hormone in rabbit is not due to through the suprarenal body but general condition by their subsistence or not.
  • 武田 登
    1961 年 7 巻 Supplement1 号 p. 661-667
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    Diluted Candida albicans with physiogical Nacl solution wasi noculated to the pregnant mouse at its ending period intravenously, into abdominal cavities and directly into uterus or placenta. Fairly large amount of inoculation of standard strain of Candida albicans up to 50mg failed to produce definite pathological findings on placenta and fetus by single dose of inoculation. Very few of them developed abortion. The infection into amniotic cavity may occur through decidua basalis, decidua marginalis or marginal sinus but mostlikely not through trophoblast.
  • 渡辺 博
    1961 年 7 巻 Supplement1 号 p. 668-677
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    On 3 cases of the acetabuloplasty operation applying the metal (22A steel) remore results were described. Following the partial bone resection of the iliac crest in the healthy rabbit, further, the effect of the metal on the new formation of the bone in repairing the bony defect was analyzed employing the intact side crest as a control. Pesults obtained were as follows : In the first 1-2 weeks of the experiment, the formation of the fibrous callus and the young bone beam was more prominent in the metalinserted side than in the control side. During the 3rd weed the metal-inserted side became poorer-formeb. In the 6th week the cellus formation was completed in both metal-inserted and control side. In the metol-inserted side, however, the insular remainings of the cartilagineous tissue were often observed, revealing the delay of the callus formation as compaired to the control side. Becauae of this experimental result, it was considered as better to remove the staple after ovar a half year. In the cotyloid roof plasty, though some delay in callus formation was observed, the application of the staple got off with small incision and was convenient and easy to be good for long term task and to get excellent result minimizing the postoperasive disturbances as seen in the usual.
  • 青木 克至
    1961 年 7 巻 Supplement1 号 p. 678-693
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    Kidney biopsy findings in 48 patients suffering from nephritis, neohrotic syndrome and juvenile hypertension were compared with their clinical and laboratory findings. The results ohtained were as follows. 1) Akute nephritis : Monerately severe inflammatory reakctions of the glomeruli, such as swelling of the tuft, proliferation of inflammatory cells and adherion of glomerular capillaries were observed even in very slight cases. 2) Chronic nephritis : a) In latent chronic form with slight albuminuria and without hyportension, almost every cases showed evidences of glomerulitis and in few cases crescent formation, hyalinization of the glomeruli were also observed. b) Characteristic changes of latent chronic nephritis with moderate albuninuria without hypertension were thickning of capillary basement membrane and of mesangium of the glomerulis. c) In eases of hypeatensive chronic nephritis with slight albuminuria, glomeritlar changes were not so severe, but adhesion, narrowing and fibrosis of the capillary tuft were recognized. d) In casis of hypertensive chronic nephritis with moderate albuminuria, thickning of the basement membrane and mesangium. swelling of the glomerular capillary tuft accompanying narrowing of the lumen were observed and hyslinization of the glomeruli were also recognized in every cases. e) In chronic azotemic nephritis, s_??_vere destruction of the glomeruli, degeneratiou and atrophy of the tubles were typical and islets of reserved, functioning nephrons were scattered in the fibrosed, infiltrated interstitial tissues, Sclerotic changes of the arteries were also remorkrble. 3) Neghrctic iyndrome : In cases of nephrotjc syndrome characteristic changes of the glomeruli were thickning of capillarg basement membrane. In electron-nicroscopic examinations, there was no thickning of the lamina deusa of the basement membrane and most remarkable changes were irregular coarseness of the lamine deusa, disappearance of the cement layer and band shaped proliferation of endothelial cytoplasma along its filtrable surface. 4) Juvenile hypertension : Differential diagnosis of this clinical eutity and hypertensive nephritis is quite difficult in many cases. In cases of juvenile hypertension, there was no specific change, except the hypertrophy of the glomeruli. There were no evidences of glomerulitis.
  • 井上 障一
    1961 年 7 巻 Supplement1 号 p. 694-702
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    Nine hundred and fifty-seven serum specimens were obtained at random from the Ground Self Defence Force personnel, who have come from all parts of Japan, and the probe agglutination test (P.A.T.) and the quantitative agglutination test (Q.A.T.) for tularemia and the Q.A.T. for Brucellosis were carried out. Further, the epidemiological investigation by means of questionnaire was also performed. The results were as follows : 1.As to tularemia, P.A.T. positives were 24 and Q.A.T. positives were 12 out of 957 specimens. namely, 2.51% and 1.25% respectively. After absorption with Brucella abortus and Brucella melitensiss, however, two sera turned to negative, so remaining positives were 22 in P.A.T. (2.29%) and 10 in Q.A.T. (1, 04%). 2.Among the P.A.T. positive group, Q.A.T. for Br. abortus was positive in 5 cases and that for Br. meitensis was positive in 7 cases. 3.The results of investigation by questionnaire showed that the rate of appearance of positives was significantly higher in snbjects who were born in Manchuria and Korea than in those born in any district in Japan, and that there were more subjects who had experiences of cooking or eating rabbits in positive group than in negative group.
  • 昭和27年度東京都の死亡を対象とした統計的観察
    荒井 英男
    1961 年 7 巻 Supplement1 号 p. 703-711
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    The statistical study was performed on the correlation between atmospheric temperature and seasonal rise and fall of daily death cases based on the death certificates in Tokyo during 1952. Cases in Izu Islands and those of acute infectious diseases were excluded. The results obtained were as follows : 1.A trend was observed that in the summer season when the temperature was high, the death frequency was generally low, but on the days of extremely high temperature the death cases increased. In the winter season when the temperature was low, the death frequency was generally high, but on the days with rather higher minimum and mean temperature the death cases decreased. On the days with higher death frequency the minimum temperature was low. In spring and autumn these trends are similar to that in winter. 2.There could be observed no particular trends of increase or decrease of the death cases on the days of typical pressure pattern of summer or winter season. 3.In summer, marked increase in death cases was seen on the days with remarkable fluctuation of diurnal temperature.A similar trend was observed also in winter, although it was not statistically significant. 4.In summer the death frequency was low on the days when the maximum temperature was remarkably lower than the preceeding day. In autumn, winter and spring there were no significant correlation. 5.In summer, the fluctuation of humidity was slight and the significant correlation between humidity and the death frequency could not be comfirmed. In winter, however, the fluctuation of humidity was remarkable and the death frequency showed a tendency to drop on the days of rather higher humidity. 6. On the days with high discomfort index, i.e. D.I.>80, the death frequency was generally high. The high discomfort index was principally due to high temperature. Accordingly the influence of D.I. on the death frequency depends for the most part upon the factor of temperature and very little upon that of humidity.
  • 飯島 達也
    1961 年 7 巻 Supplement1 号 p. 712-724
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    Mice were injected subcutaneously with Ozeki strain of Rickettsia orientalis under cold, moderate and hot thermal environment ; and their survival time after injection and the persistence of Rickettsiae in the blood and the organs of mice were observed. The survival time of the injected mice under moderate and hot environment were above three months, on the contrary, that of the injected mice under cold were less than one month. Rickettsia injected subcutaneously in mice caused uniformly splenomegaly and swelling of the inguinal lymphnodes. The infectivity of the Rickettsia in the spleen and blood of mice after subcutaneous injection were assayed at intervals by intraperitoneal injection to normal mice and their LD50 value and survival time, were measured. The appearance of Rickettsiae in the spleen and blood of injected mice could be observed readily at an early stage of infection after injection. The LD50 value, which increased rapidly, showed maxirnum at 11-12th day after injection and then decreased gradually. The Rickttsiae in the spleen showed greater LD50 value than that in the blood throughout the observation period under each thermal environment. The Rickettsiae in both the spleen and blood, showed smaller LD50 value and longer survival time under hot environment than under moderate temperature environment. LD50 value was greater and survival time was shorter under cold environment than under moderate environment. The appearance of Rickettsiae in the brain, kidney, liver and lymphnodes after subcutaneous injection showed different pattern.
  • 一杉 猛
    1961 年 7 巻 Supplement1 号 p. 725-730
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    Study and analysis of commonly obtained Electrophoresis was made by the auther. A sharp.-focussed densitometer was developed and used for obtaining true values of density, by sweeping the densitometer both along and perpendicular to the direction of emigration. Differences were found between such values and those obtained by use of generally adopted densitometers. Analysis of the sweep data on electrophoresis unfolded new findings as to the state of diffusion at the circumference. Extension and amplification of these further enabled the auther to acquire a theoretical hold for preventing errors in densitometry. It was also realized that determination of local maximum density, without the sweep, was sufficient for the purpose of quantitative determination.
  • 増田 敬三
    1961 年 7 巻 Supplement1 号 p. 731-746
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    On the basis of the statistical data on nation-wide food poisoning in the last 5 years, the author made an epidemiological study of staphylococcal food poisoning in all food poisonings and also looked into the state of contamination due to pathogenic Staphylococci of 1,614 samples from among a variety of foods on the market in the city of Yokohama in 1958. Furthermore, the author inquired into the state of contamination ascribed to pathogenic Staphylococci of 231 confection samples in 95 confectionaries as well as into the carrier-state of pathogenic Staphylococci in 332 employees and its relationship and the results are are as follows. 1. In only 22.7% of the total number of 8,278 food poisonings in the 4 years starting in 1955, causative substances were made known. 2. Food poisonings due to Staphylococci out of all bacterial food poisonings occupied such a high rate as 38.5% and starches accounted for 70% of all bacterial origins, the rate being exceedingly high. 3. The detection rate for pathogenic Staphylococci in all foods on the market was 7.3% and especially the rate was higher in confections (27.7%) and cereals and finished goods (19.6%) as compared with other foods. 4. A high ordinal correlation (r=0.928) was noticed between the detection rate by food for pathogenic Staphylococci in foods on the marked and the incidence by food of bacterial food poisoning. 5. The detection rate for pathogenic Staphylococci in confections-selling shops was higher in comparison with that in confectionaries. 6. For confections made in confectionaris where pathogenic Staphylococci were detected from employees, the detection was in strikingly higher rates than for those in confectionaries where no carriers of the said bacteria were found.
  • 矢口 秀男
    1961 年 7 巻 Supplement1 号 p. 747-766
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    The results of clinical and histological studies on 41 cases of Pustulosis palmaris et plantaris were as follows. 1) In this disease. the ratio of male and female is about 1 : 2. It seems that the eruption occurs after puberity, especially in middleaged women. 2) The exacerbation and remission of this disease were generally irregular, but in five cases, the exacerbation was observed at menstral period. 3) This disease is resistant to many forms of treatment. Steroid hormone was most effective, but the relapse occured when the dosage was decreased. 4) Histological findings were not psoriatic, but eczematoid changes were observed. 5) There is no primary relationship between sweat duct and pustule. 6) Histologically the vesicle of Pompholyx resemble the pustule of this eruption, but perivesicular spongiosis is more evident in the former. The pustule of eczema and this disease is very similar. 7) Foci were recognized in 18 of 41 cases. Remarkable changes were not found in blood examinations and bacterilogical reactions. After activating the foci in three cases, no exacerbation of the eruption was observed. By elimination of foci in 6 cases, almost complete cure was seen in one, some improvement was seen in two, and no change was found in the remaining 3 cases. As mentioned above, it is difficult to explain the aetiology of this disease only by focal infection. 8) The author holds the view that the entity of this disease may belong to the eczema groop.
  • 趙 圭輝
    1961 年 7 巻 Supplement1 号 p. 767-773
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    Experiments were carried out on rabbits. In preliminary studies, proved that the reliability of the counting red blood cells were in following order, i.e. 1. spectrophotometry by cyanhematin method 2. direct counting. 3. calculating from total Fe ions estimated and 4. colorimetry by Sahli's method. In cases of dead animals by the influence of acceleration, remarkable anemia was observed in head and the other hand, clotted blood was seen in periphery. Numbers of red cells in V. renalis decreased in left side but increased in right side. Red cells in left ventricle increased while those in right ventricle decreased. The phenomenon seemed to cause from the morphological and anatomical factors. Causes of death of animals were bleeding in parenchymatous organs by physical injury or injuries from static pressure and anemic and anoxic hypoxia in brain cortex.
  • 真田 秀夫
    1961 年 7 巻 Supplement1 号 p. 774-791
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
  • 大沼 好信
    1961 年 7 巻 Supplement1 号 p. 792-801
    発行日: 1961年
    公開日: 2014/11/22
    ジャーナル フリー
    1. Distribution of mast cells in the skin and organs was tested. 2. Histological changes in skin tissues and tissue mast cells in mongrel rats were observed during 5 days after 2000 or 8000r irradiation of ultrasoft rays on the abdominal skin. 3. Histological changes in skin tissues and tissue mast cells in Wisterstrain rats were observed 3 days after 8000r irradiation. 4. Protection against histological changes in skin tissues and tissue mast cells was proved after intraperitoneal administration of cysteine 350mg per kg or glutaihione 600mg per kg 5 mill or 1 hour before 8000r irradiation.
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