Platelet Rich Plasma (PRP), which contains large amounts of various growth factors such as platelet-derived growth factor (PDGF) and transforming growth factor-β (TGF-β), has been recently used in several kinds of operations for the purpose of enhancing hard and soft tissue healing. In order to accelerate bone growth and maturation, we added PRP to the graft material at the times of bone grafting for cleft lip with or without cleft palate (CL/P) patients with alveolar cleft. In this present study, we performed a clinical observation of these patients who were followed; 11 patients were enrolled. 7 patients with unilateral cleft lip and palate (U-CLP), 2 patients with bilateral cleft lip and palate (B-CLP), 1 patient with unilateral cleft lip and alveolar bone (U-CLA), and 1 patient with oblique facial cleft (Tessier's classification No. 4, U-CLP). The range of the age at the time of the operation was from 5 years and 11 months to 11 years and 1 month (Hellman dental stage IIC-IIIB). We performed bone grafting in 3 alveolar clefts to guide incisor, in 7 to guide lateral incisor, in 2 to guide canine. For the preparation of autologous PRP, we used Smart PReP
TM (Harvest Technologies
©), which resulted in about 220% concentration of platelets in our cases. The weight of iliac bone graft material per one alveolar cleft was 2.1g on average. In all patients, we resumed orthodontic treatment after 1 month from the operation. To evaluate grafted bone, X-ray examination was done after 1 month, 3 months, 6 months, 1 year from the operation. X-ray revealed sufficient bone bridge in the region at an early stage (3-6 months) in all cases. Wound healing of alveolar mucosa was also good in all cases. From these observations, we confirmed that PRP is very useful at times of bone grafting and beneficial for cleft lip with or without cleft palate patients.
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