The present study examined the strain differences in the type of diurnal rhythm of wheel-running among 12 strains of mice. Test was done in the home-cage situation by placing the wheel over the nest box for a week. Strains used in the experiment were A, CBA, C3H, C57BL/6J, DBA, CS, DDK, KR, KSB, NC, BS and Mom. A, DDK, DBA and KR were classified as Type-A, the mice of which were active only at night. BS, CBA, C3H, C57BL/6J, KSB and NC were of Type-B, whose wheel-running was not completely suppressed in the daytime. Mom showed the diurnal rhythm of Type-A, but differed in the other aspects. The Mom mice were hesitant to mount the wheel but were persistent to run in the wheel once they began. Thus Mom was classified as Type-A'. CS was peculiar in that it did not show the diurnal rhythm. CS mice were active both at night and in the daytime. These types of rhythm were consistently observed independently of internal factors such as age, sex, conception and estrus cycle and of external ones such as lighting, temperature and humidity. Therefore, the type of rhythm was considered to be controlled by the hereditary factors.
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