In order to investigate the behavior of the mixed atmosphere of hydrogen sulfide and hydrogen chloride during the firing of zinc sulfide, the diffusion of sulfur and chlorine from gas phase (mixed atmosphere) to solid phase (fired zinc sulfide) was studied by a tracer technique using H235S and H36Cl. The results were as follows. The amount diffused of chlorine was considerably small and was unconcerned in the existence of hydrogen sulfide, on the other hand that of sulfur decreased remarkably in the existence of hydrogen chloride. The sulfur diffused was distributed uniformly into the bulk of fired zinc sulfide, while the chlorine diffused was localized mostly on the surface. From these facts, it was suggested that the chlorine was adsorbed strongly in preference to sulfur on the surface of zinc sulfide, and the sulfur adsorbed on the surface played an important role in the sintering reaction of zinc sulfide during the firing.
Occasionally, a fortuitous accident can yield unexpected but useful information in area scanning by using honey cone collimator. The size of a point source was compared with an actual scan of that source. This scinti gram showed improper recording parameters; the energy of the radiation is high. Even though this scan represents an unrealistic situation, it illustrates how a very small source can appear to be many times larger and shaped like a six-armed starfish. The response profiles obtained by counting the various point sources (198Au; 412 keV, 131I; 364 keV, 203Hg; 279 keV) moved perpendicularly to the axes of two focusing 37-hole lead collimators (5, 10cm) in each optical focus plane. This transverse response profiles was compared with a profile taken at various angle of collimator rotation. The difference of counting rate was remarkable at 30° to the direction of collimator rotation. It was determined that the edges of the area that is “burned black” in point source scintigram represent the region somewhere between 0.1 per cent and 5 per cent of the maximum response over the center. This suggested that it might be useful to define isoresponse down to very low levels, since it is obvious that such response can affect the appearance of scan records. A difference in response of as much as a factor of two at about 3 cm off-axis suggests a reason for the starfish-like scan of the point source. Fortunately, this is not a large effect because the volume of this response region is not large. It is, however, another factor in image distortion. This effect is obtained with most hexagonal arrangement of hexagonal or round holes. In studies involving iodine-131 it became apparent that the 638 keV gamma rays in iodine-131 was the major contributor to response well off-axis. Even though spectrometry can be employed to limit response to the 364 keV region, the higher-energy gamma rays penetrate the shield, make compton interactions in the crystal, and cause frequent pulses accepted in the 364 keV region.
Activation analysis was performed for measuring protein-bound iodine (FBI) in serum and trace amounts of iodine. The samples of human serum were passed through an ion-exchange column, and to which were added small amounts of131I for recovery check. Acid digestion was then carried out by adding chromium trioxide and sulfuric acid, and distillation followed after adding phosphorous acid and hydrogen peroxide. The iodine evolved was trapped in potassium hydroxide. An aliquot of the distillate was placed in a polyethylene ampoule, and was irradiated in the pile at a thermal neutron flux of 4×1012n/cm2/sec for either 15 or 30 minutes. The induced129I with added carriers was oxidized with Laundry beach, reduced with Na2S2O5, and then extracted with carbon tetrachloride after adding sodium nitrite. The carbon tetrachloride layer was washed with dil-H2SO4and distilled water. Then128I was reduced to iodide with Na2S2O5, precipitated with silver nitrate, and assayed in a multi-channel pulse height analyzer and a Geiger-Müller counter. This post-irradiation chemistry could be performed in approximately 30 minutes. The gamma ray spectrum and decay curve indicated the absence of' nuclides other than128I and131I. FBI was determined on sera obtained from patients with thyroid diseases and normal subjects, and the values obtained were nearly the same as those by the chemical method. The duplicate determinations indicated good reproducibility. By this procedure, we could measure 2.9×10-9g of iodine.
The amount of carbons in the metabolic pool for protein synthesis and the amount of carbons in the pool consumed for the metabolism other than protein synthesis were calculated to be 7.56μg/0.5 g-gill and 3.94μg/h/0.5 g-gill, respectively. The amount of carbons in the pool for RNA synthesis and the amount of carbons in the pool consumed for the metabolism other than RNA synthesis were calculated to be 9.85×10-1μg/g-gill and 1.32×10-2μg/h/g-gill, respectively. By in vivo study, half life times were found to be 5.8 days for gill-protein, 3.96 days for midgut-protein, 2, 6 days for gill-RNA and 10.6 days for midgut-RNA. In the case of gill, the proteins about mucus glands inside of a ciliated groove were very active metabolically.
Whole-body retentions of137Cs after a single intraperitoneal administration to the young and adult mice were studied to investigate the relations between the age of animal and body retention. The effect of age on the body retention was evident. The retention curves of the younger mice decreased more rapidly than those of older ages, and the younger animals had shorter biological half-times. The urinary and fecal excretions of137Cs in the young and adult mice were also studied.
N, N-Dimethyl-β-aminoethyl p-chlorophenoxyacetate hydrochloride (Centrophenoxine) is a drug which possesses the central nervous system stimulating activity and is applied to the treatment of disturbances of consciousness in cerebral trauma. This paper described the synthesis of 14C-labeled Centrophenoxine and the metabolic fate of this compound in the mouse. Centrophenoxine [carboxyl-14C] was prepared from chloroacetic acid [carboxyl-14C] . The absorption, the excretion and the distribution of the drug were studied in the male dd strain mice after oral or intravenous administration. Centrophenoxine showed non-specific affinity to all of investigated organs and was excreted mostly in the urine within 24 hrs. The fecal excretion was little. After oral administration, it was rapidly absorbed from the stomach. The similar result was obtained in the case of oral administration of p-chlorophenoxyacetic acid which is the hydrolysate of Centrophenoxine. The concentration of the radioactivity in the brain was the similar level of the blood in a short time after intravenous injection, but thereafter it was rapidly decreased. Orally, the incorporation of the radioactivity in the brain was a little but, when dose was increased, incorporation was remarkably increased. In the urine, Centrophenoxine and p-chlorophenoxyacetic acid were detected by paper chromatography.
The comparative study on the distribution of35S-O-butyroyl thiamine disulfade (35S-BuTDS) and 35S-thiamine (35S-B1) has been carried out in adult mice injected intraperitoneally by means of whole body autoradiographic method. In the case of35S-BuTDS, the concentration of35S in various organs kept higher level and maintained lgoner time than in the case of35S-B1. 3H-BuTDS was administrated to mice by i.v., i.p., s.c., and p.o. routes, and the differences of autoradiographic distribution were compared. In the case of iv. injection, the concentration of radioactivity was higher than that of the other routes of administration. As a methods of the identification of tissues and organs, the fluorescence technique was used. Using the conventional homogenizing method, the uptake of3H in rat administered intravenously were also compared between3H-B1and3H-BuTDS and it was recognized that the affinity of3H-BuTDS for organs, tissues and blood cell was higher than that of3H-B1.