RADIOISOTOPES

A Fast Pulse-Height Ratio Circuit

Eiichi TANAKA, Hardi SIMADJAJA, Mikio YAMAMOTO

1973Volume 22Issue 4 Pages 161-164
Published: April 15, 1973
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_161

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A fast pulse-height ratio circuit suitable for position sensitive radiation detector is presented. The circuit is based on the linear to logarithmic conversion method using three semi-conductor diodes. By flowing constant standing current through these diodes in quiescent state, the circuit performance is, in principle, independent of temperature. The accuracy of the circuit is almost less than ±1.5% of full scale for input voltage range of 20-420 m V at a temperature between 0°C and 50°C.

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A Simplified Method for the Measurement of lodine-125 in the Biological Materials by Liquid Scintillation Counter

Akiko KUBODERA, Susumu TSURUFUJI

1973Volume 22Issue 4 Pages 165-169
Published: April 15, 1973
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_165

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Simple and reproducible counting methods of¹²⁵I in tissue or blood by liquid scintillation counter were investigated. It is elaborative and time consuming to pretreat the sample blood or tissue for the purpose of dissolving or suspending the samples in scintillator.
This present work was to study the methods of dipping the tube containing each sample into liquid scintillation counter vial that contains liquid scintillator. Since according to this method, the sample does not contact with liquid scintillator, it is possible to recover the sample and to re-utilize the scintillator. In addition, it is also possible to measure the radioactivity of¹²⁵I in biological materials with satisfiable reproducibility.

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On the Usefulness of Thyopac-4 Test and Thyopac Free T₄ Index

Toru MORI, Tadako KOUSAKA, Satoshi HAMADA, Yosuke TAKEDA, Katsuji IKEK ...

1973Volume 22Issue 4 Pages 170-177
Published: April 15, 1973
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_170

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The usefulness of Thyopac-4 test, a new competitive protein binding analysis for the determination of total thyroxine concentration, was studied fundamentally and clinically. The test vial contains specific adsorbing granules which do not bind T₄irreversibly, and incubation time for 30 min was found long enough to reach complete equilibrium. The effect of incubation temperature was also not so critical, and only a little effect was observed in high T₄range exceeding 20μg/100ml. Variability among kits by using pooled serum was 1.61%, and reproducibility by duplicatedly measured 11 patients' sera was excellent and the maximal difference among them was 0.9μg/100 ml. The reciprocal plotting of radioactivity in the incubation supernatant lead the stand-ard curve linear. The linearity of the standard curve was confirmed by standard T₄serum samples with 0, 3.6, 7.3, 10.9, 14.6 and 18.2μg/100 ml T₄.
Further, utilization of standard serum instead of standard T₄made the correction of extraction rate unnecessary.
Clinically the test was appraised for 80 cases with various conditions, using same serum samples, T₄by Tetrasorb and thyroxine binding capacity by Thyopac-3 and Triosorb were also determined. The test results were as follow: normal subjects (35 cases) 8.8±2.2μg/100 ml, hyperthyroidism (20 cases) 18.6±2.7μg/100 ml, hypothyroidism (19 cases) 3.9±1.9μg/100 ml and pregnancy 10.0±1.3μg/100 ml, and good differentiation was observed between hyperthyroidism and normal subjects but slight overlapping was found between normal subjects and hypothyroidism. Comparing these with T₄by Tetrasorb, a good correlation (r=+0.89) was observed, but Thyopac-4 values had slight tendency of showing higher values in low T₄range and lower values in high T₄range.
As an index for serum free T₄, free Thyopac index (Thyopac-4/Thyopac-3) was calculated. The index improved the observed high T₄in pregnancy, and was consid-ered as a better parameter, however, this index could not differentiate normal subjects from hypothyroidism completely. Another free T₄index was calculated according to our perviously reported formula (T₃RUXT₄/1-0.6 T₃RU) . Using this index, normal subjects were clearly differentiated from hypothyroidism.
With many technical advantages and good clinical results, Thyopac-4 test was considered to be a very useful routine test. Free Thyopac index as an index for free T₄was also found reasonable, however, consideration for free TBPA capacity may achieve further improvement.

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Clinical Evalution of Free Thyroxine Index (FT₄-Index) Using Res-O-Mat T₃ Kit and Res-O-Mat T₄ Kit

Katsushi WATANABE, Chikashi NAKAYAMA, Kenjiro KAWAHIRA, Kiyotaka TAJIM ...

1973Volume 22Issue 4 Pages 178-182
Published: April 15, 1973
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_178

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Res-O-Mat T₃test and Res-O-Mat T₄test were performed for 96 cases with hyperthyroidism, 195 cases with euthyroidism and 32 cases with hypothyroidism.
In T3 test, 8.5% of hyperthyroidism and 41% of hypothyroidism, and in T₄test, 4.0% of hyperthyroidism and 13% of hypothyroidism were indicated as euthyroidism.
As to FT₄-Index, normal values were from 14.1 to 3.9. All values of hyperthyroidism were above 14.1 and that of hypothyroidism were under 3.9.
No case with TBG abnormality being included in our clinical application, we could not recognize FT₄-Index as a highly effective index, but we found that FT₄-Index showed the most linear correlation with thyroid status compared with T₃test and T₄test respectively.

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Some Fundamental Accessment of Res-O-Mat ETR as Thyroid Fuction Test

Katsushi WATANABE, Kenjiro KAWAHIRA, Masao SAKURAGI, Kiyotaka TAJIMA, ...

1973Volume 22Issue 4 Pages 183-188
Published: April 15, 1973
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_183

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Res-O-Mat ETR test was developed to obtain the index indicating the free thyroxine concentration in serum by a single procedure. Effects of the various factors upon this test result were examined fundamentally. Each Res-O-Mat ETR vial in a kit had almost the same radioactivity and each micropipet had almost the same serum volume.
Few effects of error by test procedure and good reproducibility were found when standard serum was compared under the same conditions. ETR values were little effected by keeping condition of kits, incubation time and temperature and difference of added serum volume.
According to clinical application of 71 cases including 10 cases of pregnancy, ETR values were not so well correlated with the Res-O-Mat T₃values (r=0.6) and the Res-O-Mat T₄values (r=0.5) but were relatively well correlated with the FT₄-Index values calculated with T₃and T₄values.
As to 10 cases of pregnancy with normal thyroid function, they were indicated as abnormal in T₃and T₄tests only, but were all indicated as normal in ETR test.

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Multiple Peaking Effects in Semiconductor Detectors Irradiated with Nuclear Radiation

Takashi AOKI, Shunsuke NAKAMOTO, Keishi KAWABATA

1973Volume 22Issue 4 Pages 189-193
Published: April 15, 1973
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_189

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Visualization of Tumours by Scintigraphy with ⁸⁷Ga-citrate

Hirofumi YOSHII, Kimikazu TATSUSHI

1973Volume 22Issue 4 Pages 194-197
Published: April 15, 1973
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_194

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¹⁶⁹Yb-DTPA Cisternogram in Intracerebral Hemorrhage

Kazuo UEMURA, Koichi YAMAGUCHI, Zentaro ITO

1973Volume 22Issue 4 Pages 198-200
Published: April 15, 1973
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_198

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Radiation Exposure to the Personnel Using RI Injector for ^99mTc and Its Shielding Efficiency

Masao KANEKO, Chiaki YAMAMOTO, Michiko WATANABE

1973Volume 22Issue 4 Pages 201-203
Published: April 15, 1973
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_201

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The Initial Effect of Molecular Radiation Biology

Giichi YOSHII

1973Volume 22Issue 4 Pages 204-214
Published: April 15, 1973
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_204

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Present Status of the Clinical Applications in Nuclear Medicine in Japan (1972)

I. On the Testing Apparatuses

Hirotake KAKEHI, Kenji SAEGUSA

1973Volume 22Issue 4 Pages 215-219
Published: April 15, 1973
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_215

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Gage, Relay and Irradiation Facilities Using Radioisopopes (IV)

Neutron Moisture Meter

Hironori OHNO

1973Volume 22Issue 4 Pages 220-225
Published: April 15, 1973
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_220

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[title in Japanese]

1973Volume 22Issue 4 Pages A1331-A884
Published: April 15, 1973
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.22.4_A1331

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