The mixtures of the saturated benzene (or acetic acid) solution and solid ofCo (acac) 3were irradiated with thermal neutrons and the60Coretention in the mixtures was determined. The60Coretention in theCo (acac) 3—acetic acid systems was found to agree with the theoretical value estimated by using the60Coretention in the solution and solid phase. The60Coretention in the frozen acetic acid solutions ofCo (acac) 3at various concentrations was also investigated as similar heterogeneous systems.
The tumor affinity of169Yb-citrate, 67Ga-citrate, 111In-citrate and57Co-bleomycin was examined by using Yoshida sarcoma-bearing rats, and inflammation affinity of these compounds was also tested by rats with inflammation induced by croton oil injection. In our experiments, 111In-citrate showed inferior value as the tumor scanning agent compared to67Ga-citrate.57Co-bleomycin had excellent biological characteristics as the tumor scanning agent, but physical half life of cobalt-57 is too long for this purpose. So it is desirable that bleomycin is labeled with the nuclide which has excellent properties for the medical use. All compounds except111In-citrate had relatively strong affinity to the inflammation tissue. Values of the concentration ratio of these compounds between tumor and inflammatory tissue were 2.1-2.2 at 24 hours after intravenous injection. The difference of their in vivo distribution between169Yb-citrate, 67Ga-citrate and111In-citrate was investigated in order to use these compounds more properly as the tumor scanning agent. In this investigation, there was no great difference of the uptake in the tumor tissue between these compounds. But great difference in the biological properties of these compounds was observed about the retention value in the blood and the uptake rate in the bone.169Yb-citrate was rapidly cleared from the blood and was taken mostly in to the bone. So the retention values in the soft tissues became very small. On the other hand, 111In-citrate was slowly and slightly taken in to the bone from the blood, so the retention values in the soft tissues was remaining relatively high.67Ga-citrate showed the intermediate value of bone uptake rate between169Yb-citrate and111In-citrate.
The commercially available rose bengal was fractionated into different compounds using Sephadex G-25 column on gelfiltration. Physical properties of each fraction were determined. A fraction that was considered to be composed of the same substances as radiochemical impurities observed by paperchromato graphic analysis of131I-rose bengal was labeled by radioactive iodine. The effect of these labeled compounds on rose bengal liver uptake test and the distribution of the compounds in rat were investigated. The liver uptake levels of the labeled different compounds reached to the maximum at fifteen minutes after i.v. administration. The maximum liver uptake levels of these compounds were proved to be approximately one-half of the radiochemically pure labeled rose bengal liver uptake. It will be indicated that decrease of radiochemical purity of131I-rose bengal might cause the decrease of the liver uptake of131I-rose bengal. A careful attention should be payed on the purification of the raw material at the manufacturing process of131I-rose bengal, and also confirmation of radiochemical purity should be made when it is used.
A Res-O-Mat Fe kit is used for an in vitro measurement of the total iron binding capacity in serum. To disassociate iron from transferrin, ascorbic acid was used, and to remove the ionized iron, Amberlite CG-400, Type 1 resin powder was utilized. A resin strip is utilized as absorbent of residual radioiron after the serum was saturated with radioiron. The total iron-binding capacity was measured in 84 sera using this kit. Results with this method and those obtained by adding the value of unsaturated iron-binding capacity to the serum iron value showed a nearly linear correlation. This test is easy to manipulate and the reproducibility test with the same sera also was satisfactory. The normal range of total iron-binding capacity and its saturation rate with iron determined using this test kit were as follows. Male, 276±65μg/dl, 35±19% Female, 302±50μg/dl, 33±14%
Diagnostic methods like selective pulmonary angiography, bronchography or bronchospirometry for cardiovascular and pulmonary diseases, which can evaluate regional function of the lungs, have been established. However, these procedures have the disadvantage of complexity and are demanding the cooperation of the patient. Recently technical advances such as introduction of new radionuclide preparations, improved imaging devices and computer system concerned with data procedures, have further enhanced the clinical utility of nuclear medicine. An important problem in the use of xenon isotope in a given patient with cardiovascular or pulmonary disease is detecting regional pathophysiologic conditions of the lungs without any troubles. In this paper it is shown that defects or characteristic irregularities in xenon distribution during inhalation or perfusion studies can be obtained in some patients with disorders of airway tracts or blood vessels such as pulmonary thromboembolism, bronchial carcinoma and pulmonary sequestration etc.
Using a semiconductor catheter detector of side window type for β-rays, an apparatus to elicit radioisotope image by intracavity area scanning was made for trial. This apparatus enables to scan a distance of 0-15 cm, and by rotating 10° in every scan moving in close contact with the mucosal surface of the cavity, it is possible to observe incorporation of radioisotopes under the condition of extended lumen. Output from the scanner is processed by means of a small computer, and is recorded by a X-Y recorder, in addition to observe the results in diagram as well as to avoid statistical errors to be made on account of low uptake rate. This scanner was applied to diagnosis for decision of localization the early uterine cancer with32P. Comparing the results with the pathohistological findings of conization or operated specimen, it was recommendable' for diagnosis of the degree of spreading cancer on the mucosal surface quantitatively.