RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Volume 24 , Issue 1
Showing 1-16 articles out of 16 articles from the selected issue
  • Ryuichi TANAKA, Yoshiteru NAKAMURA
    1975 Volume 24 Issue 1 Pages 1-6
    Published: January 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Fading effect of cobalt-glass dosimeter was investigated in order to improve the precision of high level gamma dosimetry. It was found that fading constant depends on not only temperature but also dose, but that temperature coefficient of the fading constant does not depend on dose. An empirical formula for fading correction was determined on the basis of the fading constant measured after short period of electron beam irradiation. This method made it possible accurately to correct the fading effect over wide ranges of irradiation time, the period from cessation of irradiation till measurement, and the optical density change.
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  • Osamu FUJINO, Masakazu MATSUI, Masayuki TABUSHI, Tsunenobu SHIGEMATSU
    1975 Volume 24 Issue 1 Pages 7-11
    Published: January 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    The distribution behavior of zinc between aqueous solution phase and hydroxyapatile was studied, where solid phase was prepared by adding hydrogenphosphate ion very slowly to an aqueous solution having calcium, trace zinc and ethylenediamine at 80°C. Apparent distribution coefficient remarkably decreased as the increase of ethylenediamine which .was used as a chelating agent of zinc and a buffering agent. The true distribution coefficient, K0, was calculated by using the thermodynamic data at 80°C and its value was about 105.5. The distribution coefficient kept constant in the range of less than 10-5M of initial zinc concentration, while the coefficient gradually decreased as the zinc concentration increased over 10-5M.
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  • Michio FUJIHARA, Minezo OTSUKA, Yoshishige SATO
    1975 Volume 24 Issue 1 Pages 12-18
    Published: January 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Isolation and characterization of urinary metabolites of oxolinic acid, a new antimicrobial agent, were undertaken with rats. At an oral dose of 10 mg/kg of 14C-oxolinic acid, about 34% of the administered radioactivity was excreted in the urine within 24 hr after administration and about 95% of this urinary radioactivity was accounted for by its metabolites.
    The major metabolite (43.5%) in the urine was a conjugate of 1-ethyl-1, 4-dihydro-6, 7-dihydroxy-4-oxo-3-quinolinecarboxylic acid with an unknown compound. This indicates that a cleavage of the methylenedioxy moiety of oxolinic acid had occurred. Other metabolites were 6- and 7-monomethoxy derivatives of the above catechol and their conjugates with either glucuronic acid or a ninhydrin-positive compound. This means that the above catechol metabolite could be met hylated at either of the two hydroxy groups.
    From these results the metabolic pathways of 14C-oxolinic acid in rats seem to involve oxidation of the met hylenedioxy moiety, o-methylation and conjugation with glucuronic acid or other two unidentified compounds, one of which was ninhydrin positive.
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  • Tohru MATSUOKA, Minoru FUKUCHI, Akira KIDO, Kiyoyasu NAGAI, Yuichi KUM ...
    1975 Volume 24 Issue 1 Pages 19-24
    Published: January 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Fundamental experiments and evaluation for clinical application of gastrin radioimmunoassay kit were studied.
    The sensitivity of the assay is 12.5 pg/ml. Recoveries of increasing amounts of exogeneous gastrin added to serum ranged between 90.7 and 115.9% with a mean value of 102.8%. Serum gastrin and standard gastrin showed parallel inhibition curves against the labeled gastrin. Within-assay and between-assay reproducibility were assessed by measuring 6 replicate samples in a single assay and duplicate samples in 5 separate assays. The within-assay coefficient of variation (C. V.) was 4.5% and the betweenassay C.V., 13.4%. The specificity of the assay system was assessed in crossreactions of tetragastrin, pentagastrin, cholecystokinin-pancreozymin and secretin. Although tetragastrin and pentagastrin showed distinct inhibiting activity to the labeled gastrin over the concentration of 102pg/ml, their crossreactivities were little within the range of standard curve. Cholecystokinin-pancreozymin crossreacted distinctly over the concentration of 104μu/ml. Secretin showed no effect on the assay system. Fasting serum gastrin levels in 12 normal adult subjects ranged from 72 to 117 pg/ml with a mean value of 94.1±16.5 pg/ml. Fourteen patients with atrophic gastritis had increased levels of serum gastrin ranging from 89 to 285 pg/ml (mean 157.9±63.2 pg/ml) . Serum levels of gastrin in 6 patients with gastric ulcer and 6 with duodenal ulcer were 70-143 pg/ml (mean 96.2±29.2 pg/ml) and 97-141 pg/ml (mean 119.7±13.6 pg/ml), respectively. Six subjects who had gastrectomized showed the lower value of 59-94 pg/ml (mean 75.8±12.3 pg/ml) than that in normal subjects.
    From the present studies, gastrin radioimmunoassay kit is thought to be useful in pathophysiological diagnosis of gastroenterie diseases.
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  • Yutaka SUZUKI, Hikaru SETO, Tamio ABURANO, Kinichi HISADA
    1975 Volume 24 Issue 1 Pages 25-30
    Published: January 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    The purpose of this paper is to describe our clinical experience of adrenal scanning with 131I-19-cholesterol and discuss its clinical usefulness.
    Adrenal scanning was performed for 21 patients with hypertension. One millicurie of 131I-19-cholesterol was injected intravenously and adrenal scannings were taken 6 to 11 days after injection with a rectilinear scanner or a gamma camera. No patient had an untoward reaction to the radiopharmaceutical.
    Confirmed diagnosis was obtained in 7 of 21 patients, i.e., 3 cases of primary aldosteronism, 1 idiopathic aldosteronism, 1 Cushing's syndrome and 2 cases of the essential hypertension. Among all of the primary aldosteronism and Cushing's syndrome, adrenal scanning gave clear evidence of concentration of radioactivity at the site of tumor. In the idiopathic aldosteronism of our study, uptake of radioactivity was brightly visible on the right, while uptake by the left gland was inhibited, so this case was diagnosed incorrectly as primary aldosteronism.
    The kidney scan with 203Hg-chlormerodrin obtained without moving the patient after an adrenal scan was very useful for getting information of anatomical site of the activity.
    The effective half-life was calculated as 1.83 days by means of sequential profile whole-body scannings, and the total-body absorbed radiation dose was estimated as 0.65 rad/mCi by using MIRD pamphlets.
    Our conclusion is that the adrenal scanning with 131I-19-cholesterol is very useful for localization of the functional adrenal cortical tumor.
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  • Masahide ABE, Kengo MATSUI, Kazuo CHIBA, Hideo YAMADA, Masahiro IIO
    1975 Volume 24 Issue 1 Pages 31-35
    Published: January 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Inositol hexaphosphate occurs in nature either free or in compounds (phytic acid) . It is soluble in water and becomes a microcolloid by chelating serum calcium after intravenous injection, and forming insoluble calcium phytate, which undergoes reticulo-endotheli al localization.
    The case reports were made on all patients who had liver scan studies between August and December, 1973. Eighty-eight patients were studied with a total of 96 liver scan with 99mTc-phytate, among these patients eighteen were studied of their hepatic blood flow with 99mTc-phytate and 198Au-colloid simultaneously.
    Labeling of 99mTc-phytate was easy and stable for long time and only few free technetium was revealed (labeling yield: average 93.6%) .
    The blood clearance of 99mTc-phytate was slower than that of 198Au-colloid. This suggests that the liver scan must begin more than twenty minutes after injection. Comparing with the affinity of reticuloendothelial systems, 99mTc-phytate has higher accumulation to the spleen than that of 198Au-colloid.
    99mTc-phytate is a useful diagnostic scanning agent of the liver and spleen. Because of its superior physical characteristics excellent scans are readily obtained with minimal radiation to the patient and there have been no side effects who have received 99mTc-phytate.
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  • Atsushi ANDO, Tamio ABURANO, Kinichi HISADA, Tatsunosuke HIRAKI, Itsuk ...
    1975 Volume 24 Issue 1 Pages 36-41
    Published: January 15, 1975
    Released: December 13, 2010
    JOURNALS FREE ACCESS
    It was reported in USA recently that dimercaptosuccinate had been labeled with 99mTc-pertechnetate for imaging renal cortical morphology and its in vivo kinetics resemble that of 203Hg-chlormerodrin. To compare 99mTc-dimercaptosuccinic acid (99mTc-DMSA) with conventional kidney scanning agents (203Hg-chlormerodrin and 203Hg-salyrgan), their in vivo distributions were investigated after intravenous administration of these agents to rats. Following these experiments, clinical study was performed in patients to evaluate the practical usefulness of 99mTc-DMSA. 99mTc-DMSA was intravenously injected to the rats, and at 1, 3, 6 and 24 hours after the administration these rats were sacrificed and the uptake rate of this compound in the various organs was determined. Also in vivo distributions of 203Hg-chlormerodrin and 203Hg-salyrgan were examined. In clinical study, two subjects (25-year-old female with hyperthyrodism and 28-years-old-female with thyroid cancer) were selected from among volunteers. Two mCi of 99mTc-DSMA was administered intravenously to each patient. Scintiphotos were obtained at 5, 10, 30, 60, 120 and 240 minutes after injection with a Nuclear-Chicago Pho/Gamma HP camera.
    The uptake rate of 99mTc-DMSA in rat kidneys was 45.5% (to administered dose) and this value was slowly increased with a lapse of time. On the other hand, this values of 203Hg-chlormerodrin were 71.1% at one hour, and 86.2% at 3 hours after the administration, and after that, these values were slowly decreased. The uptake rate of 203Hg-salyrgan into the rat kidneys was 43.9% at one hour after the administration and 203Hg-salyrgan taken into the kidneys was rapidly excreted from the kidneys. In clinical study, kidneys were delineated clearly one hour after intravenous administration and this image was not varied with time. From the above-described results, it is thought that 99mTc-DMSA is an excellent kidney scanning agent and may replace the use of organoradiomercurial agents in the study of renal cortical morphology.
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  • Tadashige FUJII, Hisakata KANAI, Shozo KUSAMA, Toshio KASUGA, Fumiko N ...
    1975 Volume 24 Issue 1 Pages 42-48
    Published: January 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    The subtraction scintigraphy using 197HgCl2 and 131I-RISA was performed for the diagnosis of lung cancer. By using a data processing, a tumor image was extracted out of the original image of 197HgCl2. The signals from the scinticamera were fed into 64×64 memory through a matrix input controller, and transferred from computer to magnetic tape recorder. As first image, the image of 197HgCl2 was obtained, and as second image, the image of 131I-RISA was obtained. Both images of magnetic tape were fed into the computer. Then these images were displayed on a graphic display device. The location for subtraction was displayed by the cursor on the image of 197HgCl2. This positioned information was transferred to the computer in order to calculate count ratio (subtraction ratio) between the two images. Counts on the image of 131I-RISA were multiplied by the subtraction ratio. This normalized image (131I-RISA image) was subtracted from the image of 197HgCl2. In this subtraction, the part of non-specific concentration on the image of 197HgCl2 was erased, and hyperfixation of 197Hg in the primary and metastatic foci of lung cancer was more clarified than original unprocessed image of 197HgCl2. Uptake ratio of 197Hg and 131I in regions of interest was also discussed.
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  • Hisashi MAEKOSHI, Kunihide NISHIZAWA, Sukehiko KOGA
    1975 Volume 24 Issue 1 Pages 49-54
    Published: January 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Detailed dose distributions within the tissue under the skin surface of a finger of personnel from handling a syringe filled with radioisotopes in nuclear medicine were obtained by numerical calculations. Entrance and exit dose rates at a finger phantom were compared with the experimental results of TLD measurements.
    The size of cyrindrical radiation source is 12mmφ×9mm or 12mmφ×45mm and the wall thickness of plastic syringe is 1mm in thickness, so the volume of radioactive solution is lml or 5ml, each contains 1 mCi in activity. A water equivalent rectangular solid body of 30mm×20mm×100mm in size is assumed as a finger phantom, and actual measurements were performed with a MixDp phantom of the same size. A syringe containing radioisotope was placed directly on the phantom.
    Absorbed dose rate of a point in the phantom was calculated by assuming that γ-rays from the summation of point sources of 1 mm3 in size attenuate by self-absorption within the source, absorption by the wall of syringe and tissue, and also by inverse square law. The scattered radiation, β-rays and bremsstrahlungs were neglected. Radionuclides used were 99mTc, 131I, 203Hg, 198Au, and 59Fe.
    It is possible to know the absorbed dose of the tissue at the vicinity of surface such as stratum corneum and sweat gland by dose distributions obtained in a cross section of a finger phantom about the five radionuclides.
    Measured values of entrance dose rates were almost the same as that of calculated and exit dose rates in measured were higher than that in calculated from 10 to 30 per cent. The cause of this high value is considered due to scattered radiations from the phantom which is neglected in calculations.
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  • Takashi NAKANISHI
    1975 Volume 24 Issue 1 Pages 55-58
    Published: January 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Shin-ichi SHIMODA, Katsusuke TAKIZAWA, Etsuko MORI, Miyoko KOGURE
    1975 Volume 24 Issue 1 Pages 59-62
    Published: January 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • M. KANEKO, M. WATANABE, T. SASAKI, A. MISHIMA, S. KATO, H. YAMAGUCHI
    1975 Volume 24 Issue 1 Pages 63-66
    Published: January 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Noriharu HUZIMURA, Koichi ISHIGAMI, Masanori MATUMOTO, Kenshi KATAYAMA
    1975 Volume 24 Issue 1 Pages 67-69
    Published: January 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Akiyoshi KAJITA, Norio NAKAO
    1975 Volume 24 Issue 1 Pages 70-73
    Published: January 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Tatsuji HAMADA
    1975 Volume 24 Issue 1 Pages 74-82
    Published: January 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • 1975 Volume 24 Issue 1 Pages A1499-A1052
    Published: January 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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