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Tadatoshi YAMAMOTO, Norikatsu OOTSUKA
1982 Volume 31 Issue 12 Pages
629-635
Published: December 15, 1982
Released on J-STAGE: September 07, 2010
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Irradiation experiments of CCl
3F
were carried out with 60Co γ-
rays using the irradiation facility of the flow system. In the system, CCl
3F
was irradiated at 5.7 kGy/h (5.7×105 rad/h) and -30°C. The decomposition behavior of CCl
3F
and the influence of impurities in the circulating gas on the decomposition were examined. The result was compared with that of ampoule scale.
The decomposition yield of CCl
3F
and the yields of radiolytic products ( fluorocarbons) increased in proportion to the absorbed dose. The decomposition yield per Mrad of CCl
3F
was 0.0246 mol%/Mrad (G=2.9) .
This value was equal to 1.8 times that of the ampoule scale. The marked influence of impurities (
air, CH
4, I
2)
was recognized for the yields of halogen ions.
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Toshiyuki NEGORO, Masashi NAKAO, Akira KAGEMOTO, Masahisa HASHIMOTO
1982 Volume 31 Issue 12 Pages
636-640
Published: December 15, 1982
Released on J-STAGE: September 07, 2010
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In order to study the metabolic fate of etofenamate [I], an anti-inflammatory agent, the14C
-labelled compound of I was synthesized. The 14C
-labelled compound of flufenamic acid [II], the major metabolite of I, was also synthesized to compare the metabolic fate of I with that of II.N-Benzyl-N- [α, α, α-trifluoro-m-tolyl] [carboxyl-14C]
anthranilic acid [IV-14C]
was prepared by the reaction of the Grignard reagent prepared from N-benzyl-2-bromo-3'-trifluoromethyl-diphenylamine [III] with [
14C]
carbon dioxide. After condensation of IV-14C
with 2-benzyloxy-2'-chlorodiethylether, hydrogenolysis of the resulting ester [V-14C
] gave [carboxyl-14C]
etofenamate [I-14C
] . IV-14C
was similarly hydrogenolized to give [carboxyl-14C
] flufenamic acid [II-14C] .
The overall radiochemical yields of I-14C
and II-14C from barium [14C]
carbonate were 56 and 50%, respectively.
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—A comparison of dispersal rates for various nuclides in the solution under normal chemical operations—
Toshio MUTO, Shigeru TAKADA, Nobuhiko ITO, Akiharu KITAHARA, Haruo CHI ...
1982 Volume 31 Issue 12 Pages
641-647
Published: December 15, 1982
Released on J-STAGE: September 07, 2010
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The dispersal rates of radioisotopes under normal chemical operations were determined with a view to obtaining a fundamental information, which will be applicable to reasonable design of laboratory and safety handling of radioactive materials. A total of 16 samples was selected from widely used radioisotopes. The dispersal rate is defined as the ratio of radioactivity released from the vessel in a unit time to whole radioactivity.
The results showed that the dispersal rates varied widely according to nuclide and chemical form. The higher values were obtained from 3H
(amino acid mixture), 14C
(amino acid mixture), 35S
(cysteine) and 75Se
(selenomethionine) with average levels ranging from 4×10-5/h to 7×10-4/h. The values of radioiodines such as 125I
(sodium iodide), 125I
(triiodo-thyronine) and 131I
(sodium iodide) ranged between 4×10-6/h and 2×10-5/h. The lower values were observed for 32P
(phosphoric acid), 35S
(sodium sulfate), most nuclides of the metallic elements, etc., in which the values lied in less than the order of 10-7/h.
On the basis of these experimental evidences, the relationship between the dispersal rates and the natures of nuclides and of chemical forms is discussed.
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Makoto YOSHIDA, Kazuyoshi BINGO, Toru CHIDA, Katsuya KAWASAKI
1982 Volume 31 Issue 12 Pages
648-650
Published: December 15, 1982
Released on J-STAGE: July 21, 2010
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Masayuki OHMORI, Kazuko OHMORI
1982 Volume 31 Issue 12 Pages
651-653
Published: December 15, 1982
Released on J-STAGE: July 21, 2010
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Kunio TAKEI, Hitoshi HAGIWARA, Seisuke NAKAMURA, Masami NEI, Kazuo SUG ...
1982 Volume 31 Issue 12 Pages
654-656
Published: December 15, 1982
Released on J-STAGE: July 21, 2010
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Masato YAMASHITA, Atsuko WATANABE, Tadayoshi MIYAZAKI, Etsuro NAKAJIMA ...
1982 Volume 31 Issue 12 Pages
657-659
Published: December 15, 1982
Released on J-STAGE: July 21, 2010
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—Comparison with 99mTc-DTPA—
Masato YAMASHITA, Tadayoshi MIYAZAKI, Atsuko WATANABE, Kohichi MURAKAM ...
1982 Volume 31 Issue 12 Pages
660-663
Published: December 15, 1982
Released on J-STAGE: July 21, 2010
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Makoto WADA, Ikuko YAMAGUCHI, Yuuichi ICHIYA, Yasuo KUWABARA, Yoshihar ...
1982 Volume 31 Issue 12 Pages
664-667
Published: December 15, 1982
Released on J-STAGE: July 21, 2010
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Isao KANAMORI, Sadao MATSUO, Tokuji KIMURA, Hideo ICHIKAWA, Akiko KAWA ...
1982 Volume 31 Issue 12 Pages
668-671
Published: December 15, 1982
Released on J-STAGE: July 21, 2010
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Application of Isotope Effects in Xenobiotic Metabolism Studies
Norio KURIHARA
1982 Volume 31 Issue 12 Pages
672-680
Published: December 15, 1982
Released on J-STAGE: July 21, 2010
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1982 Volume 31 Issue 12 Pages
A83P-A120M
Published: December 15, 1982
Released on J-STAGE: July 21, 2010
JOURNAL
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