RADIOISOTOPES

Gel-type Agar Color Dosimeter

Tokuhiro OHNISHI, Eiichi HIRAOKA, Junichiro FURUTA

1982 Volume 31 Issue 8 Pages 403-406
Published: August 15, 1982
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.31.8_403

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Gel-type color dosimeter which is made by dissolving 2 kinds of dye in agar is developed. The dosimeter has following characteristics. (1) The dosimeter is easy to make and can be formed easily to any shape required. (2) The dose and dose distribution in krad region can be measured by color change of the dosimeter. (3) The 3 dimentional dose ditribution can be observed by cutting or slicing the irradiated dosimeter.
The dosimeter is used in the sprout inhibition experiment of potato by electron irradiation. From the data obtained, several irradiation conditions of the irradiating machine and irradiation method can be decided most suitably.

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Recovery and Purification of Leakage Radioactive Krypton

Tadatoshi YAMAMOTO, Kohei TSUKUI, Norikatsu OOTSUKA

1982 Volume 31 Issue 8 Pages 407-412
Published: August 15, 1982
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.31.8_407

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A recovery-purification system for radioactive Kr was constructed by enclosing an ⁸³Kr testing apparatus with an airtight vessel. Experiments were carried out to examine the recovery rate of leakage Kr and the purity of Kr recovered with the system.
The concentration of the leakage Kr in the airtight vessel was decreased to a detection limit of 0.3 ppm by the system. The recovery rate corresponded to 99.976%. The concentration of the Kr recovered was over 99.9908%. It shows that almost 100% of the radioactive Kr leaked out into the airtight vessel could be recovered and the He content in the Kr recovered could be reduced to less than 100 ppm.

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Experimental Studies on Tissue Distribution of ¹⁴C-labelled Antimicrobial Agent in Otorhinolaryngological Field

—Application of macro-autoradiography—

Kanetaka MURAI, Shunkichi BABA, Seiji MORITA, Makoto ISHIGAMI

1982 Volume 31 Issue 8 Pages 413-418
Published: August 15, 1982
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.31.8_413

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The distribution of antimicrobial agents in infected target tissues would be essential for their application to treat the sites of infection.
Taking accounts of the view point, we had reported the distribution of 3 nalidixic acid analogs in tissues which are related to otorhinolaryngology by macro-autoradiography and radiometry. We investigated here in the distribution of a nalidixic acid analog OPC-7241. This agent is 9-fluro-5-methyl-8- (4-methyl-1-piperaginyl) -6, 7-dihydro-1-oxo-1H, 5H-benzo [ij ] quinoligine-2-carboxylic acid supplied by Otsuka Pharmaceutical Co., Ltd. Autoradio-graphy was performed 30 minutes after intravenous administration of ¹⁴C-OPC-7241 in 2.96 MBq (80. 0μCi) /12. 5mg/kg to New Zieland White rabbit. Radiometry was performed 30 minutes, 1 hour and 3 hours after intravenous administration of ¹⁴C-OPC-7241 in 740 kBq (20.0 μCi) /10.0 mg/kg to NZW rabbits. Such care was taken in filling the carboxymethyl cellulose paste into the paranasal cavity, nasal cavity, oral cavity and external ear canal not to damage mechanically. Horizontal frozen sections parallel to mandibular basis were cut in 50 μm thickness in a cryostadt.
Blackening of ¹⁴C-OPC-7241 was most significant in soft palate and its expanse which is apparently the same gland-like tissues as soft palate when stained with hematoxylin and eosin. Significant radioactivity was recognized in tonsils, the cartilage of external ear canal, septal cartilage, periodontal membrane, dental pulp, muscle and concha nasalis ventralis. The levels was low in ethmoid cells, mucosa of tympanic cavity, cochlea, maxillary sinus and bone. Quantitatively, the levels of ¹⁴C-OPC-7241 radioactivity were high in soft palate, mandibular gland and tonsils. Radioactivity was significant in tongue and conhha nasalis ventralis. The levels were low in turbinates, ethmoid cells, maxillary sinus, septal cartilage, septal mucosa, cochlea, brain, optic nerve and lens.
Thus radiometric results agreed with the above autoradiographic findings.
Macro-autoradiography can be one of useful means for the evaluation chemotherapeutic agents for possible clinical application.

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A Combined Method of Scintigram and Echogram as a Trial of Integrated Image Diagnosis

Hiyoshimaru OYAMADA, Mizuki MORI, Shigeo KIMURA, Kiyoyuki NAGAIWA, Hid ...

1982 Volume 31 Issue 8 Pages 419-424
Published: August 15, 1982
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.31.8_419

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We developed a method which combines a scintigram and echogram (s) on the basis of precise positional correlation. In our method, an ordinary scintillation camera (Ohio Nuclear Σ410S) and an ultrasound diagnosis equipment (Aloka Echo Camera) are used, both of which are connected through the interface made by us. This method presents a scintigram with dotted lines through which echograms have been taken, giving us more detailed inside information which we can not obtain from scintigram only. Also obtained are positional correlations between the organ of interest and its neighbouring organs. This method is easily applicable to ordinary scintillation cameras and is useful for our daily practice.

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Comparison of ²⁰¹Tl-chloride and ⁶⁷Ga-citrate in Thyroid Tumor Scintigraphy

Osamu SENGA, Makoto MIYAKAWA, Hiroshi SHIROTA, Shinya KOBAYASHI, Akira ...

1982 Volume 31 Issue 8 Pages 425-430
Published: August 15, 1982
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.31.8_425

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Twenty-five patients with thyroid tumors were examined by ²⁰¹Tl-chloride and ⁶⁷Ga-citrate scintigraphy heterochronously in our department. All cases showed the cold nodule with ¹³¹I or ^99mTc-pertechnetate thyroid scintigraphy and each one was given a histological diagnosis after surgery or excisional biopsy. In 15 cases of thyroid carcinoma, 12 (80%) were positive by ²⁰¹Tl-uchloride; 4 (26.7%) were positive by ⁶⁷Ga-citrate.
In examining each histological type, 8 of 9 cases of papillary carcinoma (88.9%) were positive by ²⁰¹Tl-chloride. In 1 negative case the tumor was almost completely encysted; however, they were all negative by ⁶⁷Ga-citrate. In 2 patients with follicular carcinoma, both of them revealed a positive figure by ²⁰¹Tl-chloride, and one of these with oxyphilic cell carcinoma showed a positive figure by ⁶⁷Ga-citrate. In 1 case of medullary carcinoma there was slight accumulation with ²⁰¹Tl-chloride, but there was no accumulation with ⁶⁷Ga-citrate. In 3 cases of undifferentiated carcinoma, 2 patients with small carcinoma showed a negative figure by ²⁰¹Tl-chloride. However, they all showed a positive figure using ⁶⁷Ga-citrate and this medium also disclosed distant metastases of undifferentiated carcinoma.
In 10 patients with thyroid adenoma, 3 (30%) showed a positive figure by ²⁰¹Tl-chloride. Histologically, these were all tubular adenoma, but in all cases of thyroid adenoma ⁶⁷Ga-citrate revealed a negative figure.
From the above mentioned results, the following conclusion were reached. Tumors showing a positive figure by ²⁰¹Tl-chloride that elicited negative results using ⁶⁷Ga-citrate proved to be differentiated carcinoma or low differentiated types of adenoma. Surgery is indicated in these cases. All of the tumors revealing a positive figure by ⁶⁷Ga-citrate were highly malignant types. If these tumors showed a negative figure when ²⁰¹Tl-chloride was used, undifferentiated carcinoma was suggested. In undifferentiated carcinoma, ⁶⁷Ga-citrate scintigraphy is a useful procedure in locating distant metastases, in determining the area to be irradiated, and in judging the effect of therapy.

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Carbon-11 Labeling of Fludiazepam

Yoichi ARIYOSHI, Minoru MAEDA, Masaharu KOJIMA, Makiko SUEHIRO, Masaak ...

1982 Volume 31 Issue 8 Pages 431-433
Published: August 15, 1982
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.31.8_431

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Pretreatment of Organic Radioactive Liquid Waste for Incineration

—Effective addition of inorganic salt for demulsification and dehydration—

Syojiro KIMURA, Yuichi KONDO

1982 Volume 31 Issue 8 Pages 434-437
Published: August 15, 1982
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.31.8_434

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Use of the Stable Isotopes in Life Science (VIII)

Proton Activation Analysis on ¹⁸O in Biological Tissue

Yukiko OHTA

1982 Volume 31 Issue 8 Pages 438-445
Published: August 15, 1982
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.31.8_438

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[title in Japanese]

1982 Volume 31 Issue 8 Pages A51P-A78M
Published: August 15, 1982
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.31.8_A51P

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