New observation technique has been established for the thermoluminescence photography using extremely high-sensitive color films. Considering future application to the geological fields, a granite was selected as a testing material. The sliced specimens (0.5-0.7 mm in thickness), which were irradiated with a60Co source, were mounted on the heater attached with a thermocouple, which was connected to a microcomputer for measuring the temperature. The samples were heated in the temperature range of 80-400°C by operating the camerashutter controlled with the microcomputer. Four commercially available films (Kodak-1000 (ASA), -400, Sakura-400, Fuji-400) could give apparently detectable color-images of artificial thermoluminescence above a total absorbed dose of 880 Gy (88 krad) . The specimens, irradiated upto 8.4 kGy (840 krad), allowed easily to distinguish the distinct appearance of the thermoluminescence images depending on kinds of white mineral constituents. Moreover, such color images were changeable with the heating temperature. Sakura-400 film has proved the most colorful images from aspects of color tone although Kodak-1000 film showed the highest sensitivity. By applying this Kodak-1000, it was found that the characteristic color image due to natural thermoluminescence was significantly observed on the Precambrian granite which was exposed with natural radiation alone since its formation. This simple and interesting technique, obtainable surface information reflecting impurities and local crystal defects in addition to small mineral constituents, was named as the thermo-luminescence color imaging (abbreviated to TLCI) technique by the authors and its versatile applications were discussed.
2- (4- (2-Thienylhydroxymethyl) phenyl) propionic acid (I), 2- (4-carboxyphenyl) propionic acid (II), 2- (4- (5-hydroxy-2-thienylcarbonyl) phenyl) propionic acid (III) were labeled with multiple-deuterium for the purpose of using as internal standards in studies on the metabolism of 2- (4- (2-thienylcarbonyl) phenyl) propionic acid (suprofen, IV), anti-inflammatory agent, in man and animals by the mass fragmentography. I-d4 was obtained in a 93%yield from IV-d4 by reduction with sodium borohydride, and its deuterium content was 99 atom%. On the other hand, II-d4 (99 atom%D) was obtained by four-step synthesis from 2- ( (4-bromophenyl-d4) 1, 1-ethyleneglycol) propane (V) in a 43% yield and III-d4 (98.4 atom% D) by five-step synthesis from V in a 12% yield.
Acrinol in dry solid state after gamma irradiation with 80 kGy (8 Mrad) undergoes 8% decomposition, with G (-M) =30, and in wet solid state (10% moisture content) undergoes 15% decomposition, with G (-M) =56, as shown by absorbed spectrometric measurement. From these results, it is estimated that the irradiation dose of 25 kGy (2.5 Mrad) prefered by many countries as sterilization dose will achieve the radiolysis rate of 2.8% or 4.7% for dry solid state or wet solid state acrinol, respectively. The stickiness power of plaster tape made of raw rubber and polyterpene resin don't decrease with irradiation dose of less than 40 kGy (4 Mrad) . Then, the radio-sterilization on the dose of 25 kGy (2.5 Mrad) may be applied to solid pharmaceuticals such as commercial rubber adhesive plaster with acrinol pad. Besides, acrinol in 0.1% aqueous solution after irradiation of 10 kGy (1 Mrad) at room temperature undergoes 20% decomposition, with G (-M) =0.5. The radiolysis rate in this state is estimated 45% with the dose of 25 kGy (2.5 Mrad) . Then, the radio-sterilization with this dose must not be applied to liquid pharmaceuticals such as 0.1% acrinol aqueous solution. While, it was reported by Hosobuchi and Sato that the antimicrobial effect of irradiated acrinol to Staphlococcus aureus increased with irradiation dose. Then, it is expectable that some materials with antimicrobial activity are prodused by gamma irradiation.
Lymphoscintigraphies about 27 cases were examined by the methods of 11 cases of anal subcutaneous and 17 cases of rectal submucosal injections of99mTc-rhenium colloid. Para-aortic nodes and common iliac nodes were visualized in more than 70% out of the 27 cases by these methods, and those images were superior to images obtained by the conventional methods with pedal subcutaneous injections. Internal iliac nodes were visualized in 78.1% by the rectal injection method while in 27.3% by the anal injection method. It was concluded that the transrectal injection method should be used to visualize internal iliac nodes. Examination efficacies of lymphoscyntigraphies by these methods on detection of lymph nodes metastases which were confirmed by autopsy, operation, contrast lymphoangiography and/or X-ray CT. As for 131 regions of rectal and anal injected cases, sensitivity was calculated at 84.0% and specificity was at 89.6%. When the cases in which more than one definite defect was detected were scintigraphycally diagnosed as positive to metastasis and when calculated case by case, sensitivity was calculated at 90.9% and specificity was at 62, 5% in the 27 cases. Lymphatic systems were seen specifically and systematically by using lymphoscintigraphies. Though the sensitivity was not enough for a screening test of lymph node metastases and the specificity was not enough for a test to rule out lymph node metastases, lmyphoscintigraphies are clinically very useful as supplementary examinations. The lymphoscintigraphy by the method of rectal submucosal injection is much more useful as it is convenient and is the only one method to visualize the internal iliac nodes systematically.
Ca/P atomic ratios in spinal cords of seven amyotrophic lateral sclerosis (ALS) cases were determined by neutron activation and X-ray fluorescence analyses, and were compared with those of seven control cases. In order to obtain calibration curves, the standard samples with 0.01-0.1 of Ca/P atomic ratio were prepared by mixing diammonium hydrogenphosphate with calcium carbonate. In neutron activation analysis, gamma-ray spectra of49Ca and beta-ray intensities of32P produced from (n, γ) reactions of the spinal cords and standard samples were measured by Ge (Li) and GM detectors, respectively. In X-ray fluorescence analysis, the samples were excited with 1.6 MeV alpha particle beam accelerated by a Van de Graaf accelerator, manganese K X-rays from55Fe radioactive source and rhodium Ka X-rays from X-ray tube, respectively. The characteristic X-ray spectra were measured by Si (Li) or proportional detector. From the peak areas on the spectra and beta-ray intensities, the Ca/P atomic ratios in spinal cords were determined. Based on these results, the Ca/P atomic ratio of precipitate including calcium and phosphorus in spinal cord of ALS case was calculated. As a result, the Ca/P atomic ratios in spinal cords of ALS and control cases were 0.018-0.021 and 0.030-0.049, respectively. The calculated Ca/ P atomic ratio in the precipitate of ALS case was estimated to be 1.6.