RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Volume 36 , Issue 12
Showing 1-11 articles out of 11 articles from the selected issue
  • Yoshihiko MIZUMOTO, Toshio KUSAKABE, Kazuhisa SASAJIMA, Tadaharu TAMAI ...
    1987 Volume 36 Issue 12 Pages 623-627
    Published: December 15, 1987
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Aluminum content in Pepperbush standard reference material has been precisely determined by reactor neutron activation analysis. Full-energy peak area of 28Al in gamma-ray spectrum of activated sample, which is measured with a 50 cm3 Ge (Li) detector, is corrected by following coefficients;
    (1) counting efficiency of the Ge (Li) detector for disc source,
    (2) decay rate of 28Al activity during measurement,
    (3) loss of full-energy peak area caused by pulse-pile up,
    (4) 28Al production rate by 28Si (n, p) 28Al reaction,
    (5) 28Al production rate by 31P (n, α) 28Al reaction.
    Overall contribution for analytical value of these corrections is 4 to 10%.
    As a result, aluminum content in Pepperbush is determined to be 600±40μg g-1.
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  • Shigeo BABA, Yukihito SASAKI
    1987 Volume 36 Issue 12 Pages 628-632
    Published: December 15, 1987
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Synthesis of three forms of selectively duterated desipramine with high isotopic purity through acid-catalyzed hydrogen-deuterium exchange reactions and the stability of deuterium labeling are described. Deuterated desipramine labeled at positions 2, 4, 6 and 8 [DMI-d4 (I) ] was prepared directly by heating desipramine in 10% DCl-D2O at 80°C for 8 hours. Desipramine labeled at all eight aromatic positions (DMI-d8) was synthesized from iminodibenzyl-1, 2, 3, 4, 6, 7, 8, 9-d8. Desipramine labeled at positions 1, 3, 7 and 9 [DMI-d4 (II) ] was obtained by the “back-exchange” of DM1 d8 under the protio condition according to the exchange procedure of DMI-d4 (I) . Deuterium atoms labeled at positions 2, 4, 6 and 8 of desipramine were eliminated rapidly in 1 N HCl at 80°C, but those labeled at positions 1, 3, 7 and 9 of desipramine were quite chemically stable.
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  • Shigeo UCHIDA, Misako SUMIYA, Yoichiro OHMOMO
    1987 Volume 36 Issue 12 Pages 633-639
    Published: December 15, 1987
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    In assessing the internal radiation dose to man from radionuclides released from nuclear facilities including ground disposal facilities, the soil-crop plants-man pathway is one of the important ones. The information on this pathway, however, is quite limited in Japan.
    This paper focuses on transfer of 54Mn, 65Zn and 60Co from culture solution to crop plants, particularly to the edible parts of the plants. Rice plant (Oryza sativa cv. Koshihikari), spinach (Spinacea oleracea L.), soybean (Glycine max Merr.), and the other four kinds of crop plants were transplanted to culture solution in which 54MnCl2, 65ZnCl2 or 60CoCl2 were contained, and their transfer rates in each organ of the plants were obtained. The differences in the distribution patterns among the crop plant species, among the nuclides and the effect of the stable isotope concentration in the solution on their distributions were discussed in this paper. And critical crop plants for 54Mn, 65Zn and 60Co were also selected.
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  • Hikaru SETO, Masakazu YASUI, Tetsuya KAMEI, Ryusuke FUTATSUYA, Masao K ...
    1987 Volume 36 Issue 12 Pages 640-644
    Published: December 15, 1987
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Application of radiolabeled monoclonal anti-tumor antibodies for diagnosis and therapy has made remarkable progress in the past few years. Quantification of radiopharmaceutical localization is required adequate attenuation correction in SPECT imaging. Attenuation correction by transmission CT (TCT) data is one of the best method at present time. However, if a patient is moved between TCT and SPECT, this method is no more applicable.
    We developed a new attenuation correction algolism by dual energy method, using 99mTc and 111In because of similarity of these linear attenuation coefficients. The new algolism uses data of TCT with an external source of 99mTc, and requires another data from SPECT of 111In labeled monoclonal anti-tumor antibody, which are simultaneously obtained. TCT results in an attenuation map, which then serves as input into the final intrinsic correction algolism to uncorrected SPECT data. In chest phantom experiment, the attenuation corrected SPECT images revealed nearly same distribution of actual radioactivity of 111In as compared to that of uncorrected one.
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  • Hitoshi TERADA, Yasushi SHIIRE, Kiyoshi KOIZUMI, Tamio ABURANO, Norihi ...
    1987 Volume 36 Issue 12 Pages 645-649
    Published: December 15, 1987
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    To utilize 111In leukocytes in a routine work, simplified procedure for sterile leukocytes preparation and labeling with water soluble oxine sulfate was performed. Viability and chemotaxis of leukocytes were maintained during separation and labeling. Chelated rate of 111In with oxine sulfate was 93.5%. Labeling efficiency of 111In leukocytes was 93.8%. Obvious blood pool images due to remaind erythrocytes were not observed. 111In labeled leukocytes showed good migration into inflammatory focci.
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  • Hiroaki TOMIMOTO, Masayuki HAYASHI, Yasuto KAWAHARA, Fumiaki KIYOKAWA, ...
    1987 Volume 36 Issue 12 Pages 650-652
    Published: December 15, 1987
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Semi-quantitative method of IV isopropyl- (123I) -p-iodoamphetamine (123I-IMP) accumulation in cerebrum by using 123I-IMP SPECT was tried. Ratio of counts in whole cerebrum to those in normal cerebellum was calculated, and this accumulation is defined as cerebrum to cerebellum accumulation ratio. In group of patients with dementia or patients who were remaining in bed, significantly low accumulation ratio was observed, while in “normal” group, no differences in sex and aging were observed. Calculations of cerebrum to cerebellum accumulation ratio was concluded as a useful method of evaluating the accumulation of 123I-IMP in cerebrum.
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  • Shuzo UEHARA, Yasuo KUWABARA, Yuichi ICHIYA, Makoto OTSUKA, Yoshiharu ...
    1987 Volume 36 Issue 12 Pages 653-656
    Published: December 15, 1987
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    The analysis of kinetic rate constants in the compartment model for [18F] fluorodeoxyglucose (FDG) was undertaken. Four kinetic rate constants were determined with a least square fitting package SALS (Statistical Analysis with Least Squares), using the measured data of 18F activity as a function of time. SALS calculations were found to be easy and quick with high precision. The rate constants and the curves fitted by the k3 and the k4 models were compared in situations with various degree of cerebral glucose metabolism during positron emission tomography (PET) studies. The k4 model in the determination of cerebral metabolic rate for glucose (CMRglu) was much superior than the k3 model in any given situation as it always underestimates the metabolic rate. However, the k3 model produces less variation when the cerebral radioactivity curve shows steady rising pattern.
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  • Sizumori ISHIHARA, Hatsuko MORIUMA, Chiho MISHIMA, Minoru HONDA, Masah ...
    1987 Volume 36 Issue 12 Pages 657-660
    Published: December 15, 1987
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    We studied on the basic performance of a nonextraction coated tube RIA kit, DPC Aldosterone kit (Nippon DPC Corporation) . 1. The average binding CVs of the calibrators (25 to 1200 pg/ml) were stable in a range from 1.4 to 1.9%. 2. The minimum sensitivity was 17 pg/ml from 2SD method of 0 calibrator. 3. The intra-assay reproducibility test showed an average CV as 9.0%, and the inter-assay test showed as 8.8%. 4. The recovery ratios of a recovery test were 85.4 to 121.6%. 5.The correlation test with another maker's kit showed a correlation curve as y=0.970 * x+19.68 and a correlation coefciency as r=0.970. 6. The normal range, the correlation between fasting recumbency and daytime sitting, and the correlation between walking and resting, showed similar results as former reports.
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  • Akira KOBATA
    1987 Volume 36 Issue 12 Pages 661-670
    Published: December 15, 1987
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Masamichi TAKAGI
    1987 Volume 36 Issue 12 Pages 671-680
    Published: December 15, 1987
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • 1987 Volume 36 Issue 12 Pages A89P-A124M
    Published: December 15, 1987
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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