RADIOISOTOPES

An Automatic Dew-point Hygrometer Making Use of β-Ray Backscattering and Controlled at the Constant Amount of Dew

Shigeaki MATSUMOTO, Hisanobu KOBAYASHI

1988 Volume 37 Issue 8 Pages 435-440
Published: August 15, 1988
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.37.8_435

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A control system which consists of proportional and integral control to maintain the constant amount of dew was developed in this hygrometer. The dew points were measured within an accuracy of±1 °C in the ranging from -4 to 32°C. The response time for suddenly changing humidity was about 8 min.

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Distribution Model for the Intact Urokinase and Urokinases Modified by Soluble Macromolecules in Rat and Mouse Bodies

Fengxie JIN, Yuhua CHENG, Kiyoshi TODA

1988 Volume 37 Issue 8 Pages 441-447
Published: August 15, 1988
Released on J-STAGE: December 13, 2010

DOIhttps://doi.org/10.3769/radioisotopes.37.8_441

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The activity of intact urokinase (UK) and urokinases modified by soluble macromolecules (dextran and dextran sulfate sodium) in a mouse body was traced after injection of the ¹²⁵I labelled enzymes. The residual fraction of the enzyme in blood can be correlated with the time (t) as follows;
Xb=Ae^-at+Be^-bt+Ce^-ct
Since a>b>c, the residual fraction of the enzyme in blood chiefly depends on the magnitude of parameter C. The constant C for modified urokinase was larger than that for urokinase, showing the relative residual in blood was increased by modification of the enzyme. The apparent utilization in 50 min was 13.8% for intact UK, 28.1 % for the dextran- UK and 25.2% for the sulfate dextran-UK. Therefore, the apparent utilization of UK in blood was approximately doubled by the modification. Since the half-lives of UK and modified UK in kidney and liver were not long, there were no unacceptable accumulation of the enzymes.

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Construction of Experimental Apparatus for Enrichment of ⁸⁵Kr by Thermal Diffusion Method

Norikatsu OOTSUKA, Kohei TSUKUI, Tadatoshi YAMAMOTO

1988 Volume 37 Issue 8 Pages 448-451
Published: August 15, 1988
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.37.8_448

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An experimental apparatus for enrichment of ⁸⁵Kr, which consists of 8 metallic separation columns with hot wire, was designed and constructed for the development of enrichment technique of ⁸⁵Kr by thermal diffusion method. Total effective length of the column is 18.4m and maximum amount of ⁸⁵Kr treated is 200 Ci. The method for measuring temperature of the hot wire and the optimal material used for the hot wire were investigated prior to design this apparatus. It was possible to measure the temperature of the hot wire with fairly good precision by specific resistance method. Of 8 kinds of metallic wires, tungsten wire was chosen as an optimal hot wire, by taking into consideration of 7 terms for the selection of the hot wire.

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Study on the Axial Distribution of Radioactivity in ⁶⁰Co Source Pencils for High Dose-rate lrradiation and That of Gamma-ray lntensity

Takao YAMAMOTO, Tokuhiro OHNISHI, Shigeki NAKAMURA, Shinichi OKAMOTO

1988 Volume 37 Issue 8 Pages 452-455
Published: August 15, 1988
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.37.8_452

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Axial radioactivity distributions in ⁶⁰Co source pencils were measured with a lead collimator and a cavity ionization chamber. Axial γ-ray intensity distributions in the irradiation canister sorrounded by the pencils were measured with a dosimeter consisting of a silicon diode and a charge integrator. The latter distributions well agreed with those calculated from the former distributions by assuming the linear source model. The optimum radioactivity distributions for some arrangement diameters were searched from a point of view of the homogeneity in γ-ray intensity.

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Testing Performance of the Improved Pinhole Collimator and Its Application to Small Animals

Hideaki TAKANO, Touei KAKU, Tomoaki SANO, Seiichi MAEDA, Kunihiko GOTO ...

1988 Volume 37 Issue 8 Pages 456-459
Published: August 15, 1988
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.37.8_456

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Testing performance of the improved pinhole collimator of 1.5 mm aperture attached to the gamma camera was carried out with three kinds of radionuclides, ^99mTc, ⁶⁷Gaand¹³¹I, using a hand-made phantom. The results obtained in this experiment were compared to those obtained with a human pinhole collimator of 4 mm aperture. Those were nearly understood by taking account of the effective aperture of a pinhole collimator for each effective photon energy. And all scintigrams obtained from rats with various scintigraphy showed high resolution images.

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Clinical Usefulness of Trypsin Radioimmunoassay Kit

Isao KANAMORI, Satoshi NAKANO, Masakazu HURUKAWA, Yasuki OKUMURA, Chiz ...

1988 Volume 37 Issue 8 Pages 460-463
Published: August 15, 1988
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.37.8_460

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From the clinical use of RIA-gnost trypsin kit, the following results were obtained.
1. Standard curve showed a steep and good curve was shown.
2. Incubation: The condition for the first incubation was set at the room temperature for 10-24 hours and that for the second incubation at the room temperature for 3-5 hours. With these settings, satisfactory results were obtained.
3. Reproducibility and recovery: The C.V. of the reproducibility and the recovery were considered superior, and the values were below 10% and ± 3 %, respectively.
4. Correlation between trypsin and serum elestase-1: An excellent positive correlation (coefficient of correlation r=0.889) was shown.
5. Serum trypsin concentration of normal and pancreatic diseases: The normal range was from 100 to 500 ng/ml. Acute pancreatitis rose obviously. Diabetes mellitus and chronic pancreatitis was below 500 ng/ml and the pancreatic cancer showed a tendency to scatter in the range of 50-1250 ng/ml.
The above results indicated that serum trypsin can be easily measured with high precision by using this method. Thus the method is considered useful for the diagnosis of pancreatic diseases.

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Improved Performance of Waste Water Radiation Monitor

Atushi YOSHIMURA, Yasuki HIRATA

1988 Volume 37 Issue 8 Pages 464-466
Published: August 15, 1988
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.37.8_464

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Gamma ray waste water radiation monitor has been improved by using multichannel analyzer. Maximum permissible concentrations of¹²⁵Iare one thousandth lower than⁵¹Cr.This condition, the radioactive waste water cannot be pumped out occasionally. Gamma ray energy spectrum is measured by microcomputer based multichannel analyzer by which¹²⁵Iphoto-peak counts is separated from other radionuclide counts. Also detecting vessel is washed with pressured fresh water to prevent contamination.

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Standards of Compounds Labeled with Positron Nuclides Approved as Established Techniques for Medical Use and Recommendations on Practices of Their Clinical Use

Sub-committee on Medical Application of

1988 Volume 37 Issue 8 Pages 467-474
Published: August 15, 1988
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.37.8_467

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Studies on Plant Metabolism Using Stable Isotopes

Tadakatsu YONEYAMA, Hiroshi KOUCHI, Osamu ITO

1988 Volume 37 Issue 8 Pages 475-484
Published: August 15, 1988
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.37.8_475

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Introduction to the Experiment of Genetic Engineering. X. protein engineering

Hiroyuki ADACHI, Hiroshi MATSUZAWA

1988 Volume 37 Issue 8 Pages 485-493
Published: August 15, 1988
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.37.8_485

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[title in Japanese]

1988 Volume 37 Issue 8 Pages A57P-A80M
Published: August 15, 1988
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.37.8_A57P

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