RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Volume 45 , Issue 6
Showing 1-9 articles out of 9 articles from the selected issue
  • Kazuhiko NISHIOKA, Keiichi FUJIMOTO, Hiroshi KANAMARU
    1996 Volume 45 Issue 6 Pages 353-359
    Published: June 15, 1996
    Released: July 21, 2010
    JOURNALS FREE ACCESS
    (+) -9-Amino-4-demethoxy-9-deoxy-7-O- (2-deoxy-β-D-erythro-pentopyranosyl) daunomycinone (1a) was labeled with carbon-14 for use in mammalian metabolic studies. The synthesis was achieved according to the scheme illustrated in Fig. 3. Friedel-Crafts acylation of [carbonyl-14C] phthaloyl chloride (2) with the optically active bicyclic amidoketone (3) gave the tetracycline amidoketone (4) . Protection of the C13-carbonyl group of 4 with neopentylglycol furnished the ketal (5) . Treatment of 5 with 1, 3-dibromo-5, 5-dimethylhydantoin under illumination produced the oxazine (6) . Hydrolysis of the oxazine ring of 6 under acidic condition and subsequent deketalization afforded the aminoketone (8) . Glycosidation of 8 with acetyl 2-deoxy-3, 4-di-O-acetyl-D-erythro-pentopyranose in the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) provided the acetylated glycoside (10) . Alkaline hydrolysis of 10 with potassium bicarbonate gave la. The overall yield was 12.4% from 2.
    Download PDF (656K)
  • Sadaaki MIYAKE, Misako MOTEGI, Takashi OOSAWA, Kiyoaki NAKAZAWA, Hirom ...
    1996 Volume 45 Issue 6 Pages 360-368
    Published: June 15, 1996
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Accumulation and excretion of 137Cs in goldfish, Carassius auratus auratus, from radioactive diets (killifish, Oryzias latipes, meats accumulated 137Cs in the radioactive freshwater) or control diets (killifish meats mixed 137CsCl) were investigated in order to elucidate the accumulation mechanism of the radionuclide in natural living fishes.
    The accumulation of 137Cs, expressed in concentration ratio, in whole body of the fish showed a increasing tendency in proportion to the rearing time. On the other hand, the excretion of 137Cs, expressed in retention rate, in whole body rearing by administration of non-radioactive commertial diets after the accumulation above for 7 days, demonstrated a rapid decreasing at first few days, and followed a gradual decreasing tendency (the biological half lives were about 1.5 days and 52 days, respectively) .
    As for the tissues and organs, higher accumulation and higher excretion were found in the viscera than those in the muscle. It is so suggested that the metabolic turnover rate of this radionuclide for the viscera is more rapid than that for the muscle.
    From the experimental results, it was confirmed that the relative contribution by ingestion of the radioactive diets in the accumulation of 137Cs in natural environmental fish was comparatively higher in comparison with uptake of the radionuclide in the radioactive freshwater.
    With regard to the difference between the radioactive diets and the control diets, the accumulation of 137Cs in whole body of the fish from the radioactive diets was less than that from the control diets to rearing 5 days, but afterward was not different. The difference of the accumulation between these diets will be attributable to that of the metabolic turnover between these diets.
    Download PDF (1004K)
  • Yuka YAMAMOTO, Toshiaki KUSUHARA, Yoshihiko KUMAZAWA, Yoshihiro NISHIY ...
    1996 Volume 45 Issue 6 Pages 369-374
    Published: June 15, 1996
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    The simultaneous acquisition method in SPECT has some advantages, such as potentially doubling throughput in an examination and halving the acquisition time. However, interradionuclide scattering limits diagnostic accuracy. We evaluated 99mTc and 201Tl scattering using three energy windows. These windows were set at 71 keV with 15% window width for 201Tl images, at 90 keV with 10% window width for scatter images, and at 140 keV with 15% window width for 99mTc images. From phantom studies, the scatter correction coefficient, a, was measured to be 1.07, while the crosstalk correction coefficient, β, was measured to be 0.14. The corrected counts, a, in the 71 keV window for 201Tl image and the corrected counts, b, in the 140 keV window for 99mTc image were given as follows : a =A-αC, b =B-βa, where A is the raw counts in the 71 keV window, B the raw counts in the 140 keV window, and C the raw counts in the 90 keV window. Simultaneous dual-radionuclide 99mTc/201Tl scintigraphy is feasible using 99mTc scatter and 201Tl crosstalk correction coefficients.
    Download PDF (621K)
  • Kazuyoshi UEMATSU, Hisashi YAMAZAKI, Mineo SATO
    1996 Volume 45 Issue 6 Pages 375-377
    Published: June 15, 1996
    Released: July 21, 2010
    JOURNALS FREE ACCESS
    Download PDF (302K)
  • Tsutomu ICHIMIYA, Tsutomu NARITA, Kensuke KITAO
    1996 Volume 45 Issue 6 Pages 378-405
    Published: June 15, 1996
    Released: July 21, 2010
    JOURNALS FREE ACCESS
    Download PDF (3207K)
  • 1996 Volume 45 Issue 6 Pages 406
    Published: 1996
    Released: July 21, 2010
    JOURNALS FREE ACCESS
    Download PDF (28K)
  • [in Japanese]
    1996 Volume 45 Issue 6 Pages 407-408
    Published: June 15, 1996
    Released: July 21, 2010
    JOURNALS FREE ACCESS
    Download PDF (289K)
  • [in Japanese]
    1996 Volume 45 Issue 6 Pages 409-410
    Published: June 15, 1996
    Released: July 21, 2010
    JOURNALS FREE ACCESS
    Download PDF (323K)
  • [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1996 Volume 45 Issue 6 Pages 411-412
    Published: June 15, 1996
    Released: July 21, 2010
    JOURNALS FREE ACCESS
    Download PDF (310K)
feedback
Top