Organic polymers irradiated with high-energy radiation in the presence of oxygen are gradually oxidized through chemical reactions between free radicals and oxygen. Because oxygen permeation is responsible for radiation-induced oxidation, gas barrier coating is a promising way to improve the radiation resistance of a polymer. In the present work, oxygen barrier silica coating was attempted for 1 mm thick polypropylene by RF magnetron sputtering. Microscopic FT-IR analysis for gamma-irradiated samples showed that radiation-induced oxidation of polypropylene can be effectively suppressed by about 100 nm thick silica coating.
It has been reported that11C-methionine (Met) is taken up in greater amounts when tumor cells are actively proliferating. This observation suggests that Met uptake depends on the cell cycle. This study was aimed at investigating the relationship between the cell cycle of cultured human cancer cells and Met uptake, and obtaining basic information for Met PET interpretation. HeLa S3 cells were synchronized by the double thymidine block method, and the relationship between cells synchronized at each phase and Met uptake was investigated during 14 hours after release. As a result, Met uptake was 73% of the peak level in the early S-phase immediately after release, gradually increased, and peaked in the early G2/M phase. Subsequently, Met uptake steeply declined over the late G2/M phase to 44% in the G1 phase. These results indicate that Met uptake depends on the cell cycle : Met accumulates highly from the S through G2/M phases and maximally in the G2 phase. Met PET seems to produce images reflecting the mitotic index of tumor cells, and predicts that more rapidly progressing malignant tumors will show a higher Met uptake.
Bremsstrahlung energy spectra induced by beta ray from radionuclides3H, 63Ni, 14C, 147Pm, 90Sr, 32P and90Yare calculated by using numerical data of radiation yield published by Berger et. al. and compared with those obtained from classical approximate expressions of Wu and Segré. The results for3H, 63Ni, 14C and147Pm are in good agreement with those from Segré's, while spectra from such as32P and90Y are similar to those obtained by using Wu's expression. The result for90Sr is in fair agreement with those from Wu's and Segré's.