The trouble of
99Mo delivery that occurred in 2009 has led to the discussion of the domestic production of
99Mo. The production method that is now being considered is the neutron activation method. This method uses either
98Mo or
100Mo, whose natural abundance ratios are 24% and 10%, respectively, as the target to yield
99Mo and differs from the present fission method that uses
235U. The neutron activation method is effective in terms of the management of nuclear non-proliferation and waste disposal, but there are many issues to be solved in order to stably produce
99mTc solution that is suited for radiopharmaceutical manufacture.
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