Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Volume 62 , Issue 8
Showing 1-6 articles out of 6 articles from the selected issue
  • Takeshi KOBAYASHI, Teiko TOYOGUCHI, Kazuhiro KATO, Fuyuki TOKANAI, Tad ...
    2013 Volume 62 Issue 8 Pages 517-523
    Published: 2013
    Released: August 28, 2013
    The understanding of human pharmacokinetics is important for development of new drugs. Microdosing studies have been proposed as means of obtaining human pharmacokinetics information at early stages of drug development. Accelerator mass spectrometry (AMS) has high detection sensitivity and is expected to play an important role in microdose trials. In this study, we used the AMS microdosing facility at Yamagata University to measure the concentration of 14C in 14C-oxaliplatin-spiked serum samples. The calibration curve of 14C concentration in serum was linear, and the correlation coefficient was 0.9994. The precision, accuracy, and stability values obtained (freeze and thaw cycles, and short- and long-term stability) satisfied the criteria. The mean background 14C concentrations in samples of 6 healthy Japanese volunteers were 1.635dpm/mL in blood and 0.56dpm/mL in plasma. These results suggest the suitability of AMS-based quantitation for analyzing samples from microdosing studies.
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  • Takayuki HIRONIWA, Hiroshi ISHII, Chikahiro SATOH, Munetaka NAKATA
    2013 Volume 62 Issue 8 Pages 525-531
    Published: 2013
    Released: August 28, 2013
    To detect γ-ray irradiation traces for foods, thermal chemiluminescence spectra of food packages were measured with a multichannel Fourier-transform chemiluminescence(FT-CL) spectrometer, where the irradiation dose was chosen in the range between 10Gy and 10kGy. It was found that the highest sensitivity for the γ-ray irradiation was ?? 10Gy dose, which was much better than that of the ESR method. In addition, the γ-ray irradiation traces of the samples were detectable after 14 months. It was confirmed that the FT-CL is useful as a screening method to detect γ-ray irradiation traces for foods.
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  • Medical Science and Pharmaceutical Committee, Japan Radioisotope Assoc ...
    2013 Volume 62 Issue 8 Pages 545-608
    Published: 2013
    Released: August 28, 2013
    The Subcommittee on Survey of Nuclear Medicine Practice in Japan has performed a nationwide questionnaire surveys every five years since 1982. The latest questionnaire survey was performed in June 2012. The estimated total number of the annual examinations was 1.15 millions, 19% less than that of the last survey in 2007. The scintigraphic examination most frequently performed was bone scintigraphy, followed by myocardial and brain perfusion scintigraphy in order. The number of PET studies and radionuclide targeted therapies increased by 40% and 62%, respectively, as compared to the 2007's survey. The increase was attributable to growing uses of commercially delivered FDG, and the newly started radionuclide targeted therapy for patients with metastatic bone tumor or malignant lymphoma, in addition to 131I therapy for patients with thyroid cancer or Graves' disease. The number of in vitro radioassays has been decreasing continuously since 1992.
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Serial Lecture
Basics and Applications of Mössbauer Spectrometry
    2013 Volume 62 Issue 8 Pages 609-622
    Published: 2013
    Released: August 28, 2013
    Functions of heme proteins are finely tuned by the electronic and coordination structure of the heme (iron porphyrin complex) placed in the active site of protein. Therefore, it is quite important to reveal the physicochemical properties of a wide variety of synthetic model heme complexes for better understanding the functions and reaction mechanisms of heme proteins. The heme electronic structures have been determined by the combined analysis of NMR, ESR, Mössbauer, and IR spectrometry as well as SQUID(superconducting quantum interference device) magnetometry and X-ray crystallography. Specifically, two kinds of electronic ground states observed in low-spin iron(III) porphyrin complexes, i.e. commonly observed(dxy)2(dxz, dyz)3 and less common(dxz, dyz)4(dxy)1, as well as the novel spin crossover phenomena involving the intermediate-spin state are described. Special interest is the mono-imidazole complexes showing the spin crossover among all the possible spin states in iron(III) porphyrin complexes, i.e., S=1/2, 3/2, and 5/2. The novel electronic structures mentioned above are recently pointed out to involve in the catalytic process of some naturally occurring heme proteins.
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